Zobrazeno 1 - 10
of 7 454
pro vyhledávání: '"J, Charles"'
Publikováno v:
Methods Mol Biol . 2024:2716:223-240
Building and analysing knowledge graphs (KGs) to aid drug discovery is a topical area of research. A salient feature of KGs is their ability to combine many heterogeneous data sources in a format that facilitates discovering connections. The utility
Externí odkaz:
http://arxiv.org/abs/2310.15572
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract The prevention and treatment of many herpesvirus associated diseases is based on the utilization of antiviral therapies, however therapeutic success is limited by the development of drug resistance. Currently no single database cataloguing r
Externí odkaz:
https://doaj.org/article/da04819da95741aa9a32598f2b2aa49a
Autor:
Nicola J. A. Scott, Timothy C. R. Prickett, Christopher J. Charles, Eric A. Espiner, A. Mark Richards, Miriam T. Rademaker
Publikováno v:
Experimental Physiology, Vol 109, Iss 8, Pp 1305-1316 (2024)
Abstract Osteocrin (OSTN) is an endogenous protein sharing structural similarities with the natriuretic peptides [NPs; atrial (ANP), B‐type (BNP) and C‐type (CNP) NP], which are hormones known for their crucial role in maintaining pressure/volume
Externí odkaz:
https://doaj.org/article/2a7d5c0957894317900789ec13b024b4
Autor:
Nicola J. A. Scott, Christopher J. Charles, Timothy C. R. Prickett, Christopher M. Frampton, A. Mark Richards, Miriam T. Rademaker
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 23 (2024)
Background LCZ696 (sacubitril/valsartan) antagonizes the renin–angiotensin system while simultaneously augmenting the natriuretic peptides (NPs). Inhibition of phosphodiesterase 9 inhibition (PDE9i), which hydrolyses NP‐generated cGMP may be a mo
Externí odkaz:
https://doaj.org/article/60c3f5ac083d435d97165eabcae536d8
Publikováno v:
CNS Oncology, Vol 13, Iss 1 (2024)
Atypical teratoid rhabdoid tumors (AT/RT) are rare and highly malignant CNS neoplasms primarily affecting children. Adult cases are extremely uncommon, with only approximately 92 reported. Spinal AT/RT in adults is particularly rare. Here, we present
Externí odkaz:
https://doaj.org/article/cd857815a19b432e8eadd3284cc3f6ef