Zobrazeno 1 - 10
of 390
pro vyhledávání: '"J, Carlos Menéndez"'
Autor:
Bayu Ardiansah, Ahmad Farhan, Amalia Firdaus, Titin Ariyani, Mochammad Arfin Fardiansyah Nasution, Arif Fadlan, Antonius Herry Cahyana, Erwahyuni Endang Prabandari, J. Carlos Menéndez
Publikováno v:
Journal of Saudi Chemical Society, Vol 28, Iss 2, Pp 101826- (2024)
Eugenol, a primary component of clove oil, is a compound of considerable interest in medicinal chemistry due to its demonstrated potential as an effective agent in various therapeutic applications. In this study, a series of eugenol derivatives were
Externí odkaz:
https://doaj.org/article/ec83aa92a0c74fed8b09e983f0f11000
Autor:
Juan F. González, María-Auxiliadora Dea-Ayuela, Lena Huck, José María Orduña, Francisco Bolás-Fernández, Elena de la Cuesta, Nazia Haseen, Ashraf Ali Mohammed, J. Carlos Menéndez
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 487 (2024)
We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a B
Externí odkaz:
https://doaj.org/article/81f7d0e10c1b4f46b4287417861449ee
Autor:
Álvaro Sarabia-Vallejo, Ana Molina, Mónica Martínez-Orts, Alice D’Onofrio, Matteo Staderini, Maria Laura Bolognesi, M. Antonia Martín, Ana I. Olives, J. Carlos Menéndez
Publikováno v:
Molecules, Vol 29, Iss 6, p 1196 (2024)
A group of functionalized fluorene derivatives that are structurally similar to the cellular prion protein ligand N,N′-(methylenedi-4,1-phenylene)bis [2-(1-pyrrolidinyl)acetamide] (GN8) have been synthesized. These compounds show remarkable native
Externí odkaz:
https://doaj.org/article/2dc68429f0064faeb1bb20beec080fde
Autor:
Carmen Avendaño, Pilar López-Alvarado, José María Pérez, Miguel Ángel Alonso, Eva Pascual-Alfonso, Miriam Ruiz-Serrano, J. Carlos Menéndez
Publikováno v:
Molecules, Vol 29, Iss 2, p 489 (2024)
The 1,8-Diazaanthracene-2,9,10-triones, their 5,8-dihydro derivatives, and 1,8-diazaanthracene-2,7,9,10-tetraones, structurally related to the diazaquinomycin family of natural products, were synthesized in a regioselective fashion employing Diels–
Externí odkaz:
https://doaj.org/article/a806e3180dcf4aef9507d363db714e67
Publikováno v:
Molbank, Vol 2023, Iss 2, p M1616 (2023)
The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole. The formation of this compound was e
Externí odkaz:
https://doaj.org/article/339b70960d7c4ab0a5e408c185fe5ba7
Autor:
Álvaro Sarabia-Vallejo, María del Mar Caja, Ana I. Olives, M. Antonia Martín, J. Carlos Menéndez
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2345 (2023)
Many active pharmaceutical ingredients show low oral bioavailability due to factors such as poor solubility and physical and chemical instability. The formation of inclusion complexes with cyclodextrins, as well as cyclodextrin-based polymers, nanosp
Externí odkaz:
https://doaj.org/article/c1a83dea4e0b4d31a5d7e2ea2de61ca7
Autor:
Damiano Rocchi, Juan F. González, Olmo Martín-Cámara, Maria Grazia Perrone, Morena Miciaccia, Antonio Scilimati, Celine Decouty-Pérez, Esther Parada, Javier Egea, J. Carlos Menéndez
Publikováno v:
Molecules, Vol 28, Iss 14, p 5374 (2023)
Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role of cyclooxygenase-1 (COX-1) inhibition has been rather neglected. We rep
Externí odkaz:
https://doaj.org/article/bf73d602628f464bb30ff877d58116e5
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1464 (2023)
Quinones can in principle be viewed as a double-edged sword in the treatment of neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic due to covalent and redox modification of biomolecules. Nevertheless, low doses
Externí odkaz:
https://doaj.org/article/220ad51d588440348db91af0e1ab561f
Autor:
Lucía Pérez-Regidor, Joan Guzmán-Caldentey, Nils Oberhauser, Carmen Punzón, Balázs Balogh, José R. Pedro, Eva Falomir, Alessandra Nurisso, Péter Mátyus, J. Carlos Menéndez, Belén de Andrés, Manuel Fresno, Sonsoles Martín-Santamaría
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2326 (2022)
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery of novel TLR4 modulators w
Externí odkaz:
https://doaj.org/article/0f1178007a05470795f7fc9e89be0e3d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1009 (2022)
Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context o
Externí odkaz:
https://doaj.org/article/080b09859ab24cc1b26661185b669511