Modulation of PTH1R signaling by an ECD binding antibody results in inhibition of β-arrestin 2 coupling

Autor: Lisa Joedicke, David McMillan, Rebecca J. Burnley, Bernadette Byrne, Marta Westwood, Kaushik Sarkar, Michael John Wright

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

Parathyroid hormone receptor 1 (PTH1R) belongs to the secretin class of G protein coupled receptors (GPCRs) and natively binds parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP). Ligand binding to PTH1R involves binding to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab29a5fb6d133f89674926079ef393b
https://pubmed.ncbi.nlm.nih.gov/31594997

Education Coupled With In-Situ High Fidelity Simulation Improves Medical-Surgical RN Code Blue Comfort Levels

Autor: D M, Wallace, J, Burnley, B, Langston, M, Russell, K, White, M H, Stroud

Publikováno v: The Journal of the Arkansas Medical Society. 113(9)

Pediatric, cardiopulmonary arrest is a rare event outside intensive care units in children's hospitals. Medical-surgical RNs rarely are involved in code situations and are often uncomfortable in performing necessary tasks. We implemented a multi-disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b37740943b6082d5ed169082482ef314
https://pubmed.ncbi.nlm.nih.gov/30383343

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase

Autor: Perdita E. Barran, Rebecca J. Burnley, Luiz Pedro S. de Carvalho, Richard J. K. Taylor, João Pedro Pisco, Massimiliano Porrini, Victoria Ordsmith, Rachel A. Garlish, Thomas A. Jowitt, Kamila J. Pacholarz, Gerald Larrouy-Maumus

Publikováno v: Pacholarz, K J, Burnley, R J, Jowitt, T A, Ordsmith, V, Pisco, J P, Porrini, M, Larrouy-Maumus, G, Garlish, R A, Taylor, R J, de Carvalho, L P S & Barran, P E 2017, ' Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase ', Structure (London, England : 1993), vol. 25, no. 5, pp. 730-738 . https://doi.org/10.1016/j.str.2017.03.005
Structure(London, England:1993)
738.e4

Summary MtATP-phosphoribosyltransferase (MtATP-PRT) is an enzyme catalyzing the first step of the biosynthesis of L-histidine in Mycobacterium tuberculosis, and proposed to be regulated via an allosteric mechanism. Native mass spectrometry (MS) revea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a0ccf0d281dbef7023541d901ef70
https://www.research.manchester.ac.uk/portal/en/publications/hybrid-mass-spectrometry-approaches-to-determine-how-lhistidine-feedback-regulates-the-enzyzme-mtatpphosphoribosyltransferase(c91580c8-e753-4acf-ae73-f64ac8047573).html

Application of the Exactive Plus EMR for automated protein-ligand screening by non-covalent mass spectrometry

Autor: Rebecca J. Burnley, Rachel A. Garlish, Hannah J. Maple, Mark Allen, Richard J. K. Taylor, Olaf Scheibner, Maciej Bromirski, Mark Baumert

Publikováno v: Rapid Communications in Mass Spectrometry. 28:1561-1568

RATIONALE Non-covalent mass spectrometry (MS) offers considerable potential for protein-ligand screening in drug discovery programmes. However, there are some limitations with the time-of-flight (TOF) instrumentation typically employed that restrict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f2f303d8626f4fc02a883c53aed5b7
https://doi.org/10.1002/rcm.6925

Application of the Exactive Plus EMR for automated protein-ligand screening by non-covalent mass spectrometry

Autor: Hannah J, Maple, Olaf, Scheibner, Mark, Baumert, Mark, Allen, Richard J, Taylor, Rachel A, Garlish, Maciej, Bromirski, Rebecca J, Burnley

Publikováno v: Rapid communications in mass spectrometry : RCM. 28(13)

Non-covalent mass spectrometry (MS) offers considerable potential for protein-ligand screening in drug discovery programmes. However, there are some limitations with the time-of-flight (TOF) instrumentation typically employed that restrict the applic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c27b84b8be5a06a2be42d79591715743
https://pubmed.ncbi.nlm.nih.gov/24861608