Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

Autor: Nicola Logan, David Wright, Rebecca J Brownlie, Robert J Salmond, Rose Zamoyska, Alexandra Rose Teagle, Patricia Castro-Sanchez, Simran S Kapoor

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)

Background Adoptive cell therapy (ACT) is a promising strategy for treating cancer, yet it faces several challenges such as lack of long-term protection due to T cell exhaustion induced by chronic TCR stimulation in the tumor microenvironment. One be

Externí odkaz: https://doaj.org/article/637a5295bc98436b883e169c1ad3e400

Phosphorus price spikes: A wake-up call for phosphorus resilience

Autor: Will J. Brownlie, Mark A. Sutton, Dana Cordell, Dave S. Reay, Kate V. Heal, Paul J. A. Withers, Isabelle Vanderbeck, Bryan M. Spears

Publikováno v: Frontiers in Sustainable Food Systems, Vol 7 (2023)

Food systems depend on reliable supplies of phosphorus to fertilize soils. Since 2020, a pandemic, geopolitical disputes, trade wars and escalating fuel prices have driven a >400% increase in phosphorus commodity prices, contributing to the current f

Externí odkaz: https://doaj.org/article/096fbe13813b42d7b683cc53be2a31a8

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation

Autor: Helen Carrasco Hope, Rebecca J. Brownlie, Christopher M. Fife, Lynette Steele, Mihaela Lorger, Robert J. Salmond

Publikováno v: JCI Insight, Vol 6, Iss 9 (2021)

T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surf

Externí odkaz: https://doaj.org/article/f09dbfc3ff2c45ebbd590954c6ced5e4

Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

Autor: Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

TGFβ secretion in the tumor microenvironment inhibits T cell-mediated anti-tumor immune responses. Here the authors show that a mutation predisposing to autoimmune diseases confers T cells resistance to TGFβ inhibitory action and could be exploited

Externí odkaz: https://doaj.org/article/cdc63d275db74abeb71860f4aa4a1656

Global actions for a sustainable phosphorus future

Autor: Christian Kabbe, Kate Heal, Mark A. Sutton, Ludwig Hermann, David S. Reay, Will J. Brownlie, Bryan M. Spears

Publikováno v: Brownlie, W, Sutton, M, Reay, D, Heal, K, Hermann, L, Kabbe, C & Spears, B M 2021, ' Global actions for a sustainable phosphorus future ', Nature Food, vol. 2, pp. 71-74 . https://doi.org/10.1038/s43016-021-00232-w

Unsustainable phosphorus use is pushing food security further from reach1,2, leaving a legacy of polluted freshwaters, many now beyond ecological restoration3. Ten years have passed since the global anthropogenic flow of phosphorus was identified to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5465448dc4d08af9f46e0d49de93b7
https://doi.org/10.1038/s43016-021-00232-w