Zobrazeno 1 - 10
of 338
pro vyhledávání: '"J, Brockmann"'
Autor:
Sarah J. Brockmann, Eva Buck, Tiziana Casoli, João L. Meirelles, Wolfgang P. Ruf, Paolo Fabbietti, Karlheinz Holzmann, Jochen H. Weishaupt, Albert C. Ludolph, Fiorenzo Conti, Karin M. Danzer
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-13 (2023)
Abstract Background ALS is a heterogeneous disease in which different factors such as mitochondrial phenotypes act in combination with a genetic predisposition. This study addresses the question of whether homoplasmic (total mitochondrial genome of a
Externí odkaz:
https://doaj.org/article/5c05a220789c40f78e5b3a267fbf6094
Autor:
Wolfgang P. Ruf, Axel Freischmidt, Veselin Grozdanov, Valerie Roth, Sarah J. Brockmann, Brit Mollenhauer, Dorothea Martin, Bernhard Haslinger, Katrin Fundel-Clemens, Markus Otto, Christine von Arnim, Karlheinz Holzmann, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Publikováno v:
Cells, Vol 10, Iss 4, p 791 (2021)
Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the in
Externí odkaz:
https://doaj.org/article/808a1008cd304e32a6a70f47921e6f17
Autor:
Anika M. Helferich, Peter M. Andersen, Priyanka Tripathi, Vitaly Zimyanin, Sarah J Brockmann, Axel Freischmidt, Albert C. Ludolph, Hannes Glaß, Joachim Weis, Eleonora Aronica, Andreas Hermann, Peter J. Oefner, Karin M Danzer, Maria Demestre, Karlheinz Holzmann, Alfred Yamoah, Anand Goswami, Tobias M. Böckers, Jörg Reinders, Jochen H. Weishaupt, Katharina Limm, Ina Poser
Publikováno v:
Brain
Brain 144(4), 1214-1229 (2021). doi:10.1093/brain/awab018
Brain, 144(4), 1214-1229. Oxford University Press
Brain 144(4), 1214-1229 (2021). doi:10.1093/brain/awab018
Brain, 144(4), 1214-1229. Oxford University Press
Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases. Previously, we identified serum microRNAs downregulated in familial ALS, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691c4d51f5ea8d795f65a3e3483b9bef
https://doi.org/10.1093/brain/awab018
https://doi.org/10.1093/brain/awab018
Akademický článek
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Autor:
H. Alhumaidan, I. Ibrahim, D. Broering, H. Aleid, K. Almeshari, T. Ali, I. Alahmadi, E. Hammad, H. Elgamal, Y. Shah, J. Brockmann, M. Hussein
Publikováno v:
Transplantation Proceedings. 51:512-516
Background A significant gap exists between demand and supply of organs for patients with end-stage renal disease. To increase the donor pool, kidney transplantation is performed across ABO- and HLA-incompatible barriers. ABO-incompatible kidney tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1674dc59e63040b2c9bae2687e2cd3
https://doi.org/10.1016/j.transproceed.2019.01.002
https://doi.org/10.1016/j.transproceed.2019.01.002
Autor:
Lena Fischer, Clémentine E. Philibert, Karin M Danzer, Axel Freischmidt, Eva Buck, Simon Tii Mungwa, Michael Sendtner, Jochen H. Weishaupt, Patrick Lüningschrör, Clara Bruno, Takashi Satoh, Albert C. Ludolph, David A. Brenner, Johannes Ulmer, Shizuo Akira, Corinna Bliederhäuser, Séverine Boillée, Kirsten Sieverding, Sarah J Brockmann, Benjamin Mayer, Christian S. Lobsiger
Publikováno v:
Journal of Experimental Medicine. 216:267-278
Heterozygous loss-of-function mutations of TANK-binding kinase 1 ( TBK1 ) cause familial ALS, yet downstream mechanisms of TBK1 mutations remained elusive. TBK1 is a pleiotropic kinase involved in the regulation of selective autophagy and inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d71d4c8bd775ab368a19e23a86d9ba2b
https://doi.org/10.1084/jem.20180729
https://doi.org/10.1084/jem.20180729
Autor:
Valerie Roth, Brit Mollenhauer, Jochen H. Weishaupt, Bernhard Haslinger, Veselin Grozdanov, Karin M Danzer, Axel Freischmidt, Albert C. Ludolph, Karlheinz Holzmann, Wolfgang Ruf, Katrin Fundel-Clemens, Christine A. F. von Arnim, Markus Otto, Sarah J Brockmann, Dorothea Martin
Publikováno v:
Cells, Vol 10, Iss 791, p 791 (2021)
Cells
Volume 10
Issue 4
Cells 10(4), 791-(2021). doi:10.3390/cells10040791
Cells
Volume 10
Issue 4
Cells 10(4), 791-(2021). doi:10.3390/cells10040791
Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d352a1026713ad9c5d6baabe820c7134
https://www.mdpi.com/2073-4409/10/4/791
https://www.mdpi.com/2073-4409/10/4/791
Autor:
Thorsten Benter, Klaus J. Brockmann, Hendrik Kersten, Kai Kroll, Amelia Peterson, Kirsten Haberer, Alexander Makarov
Publikováno v:
Journal of the American Society for Mass Spectrometry. 27:607-614
This contribution reports on the development of an atmospheric pressure photoionization (APPI) source interfacing a gas chromatograph (GC) with a bench-top Orbitrap high resolution mass spectrometer (MS). We present efforts on method development aimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e19ade55350aac12cc77894bf88687
https://doi.org/10.1007/s13361-015-1320-x
https://doi.org/10.1007/s13361-015-1320-x
Autor:
David, Brenner, Kirsten, Sieverding, Clara, Bruno, Patrick, Lüningschrör, Eva, Buck, Simon, Mungwa, Lena, Fischer, Sarah J, Brockmann, Johannes, Ulmer, Corinna, Bliederhäuser, Clémentine E, Philibert, Takashi, Satoh, Shizuo, Akira, Séverine, Boillée, Benjamin, Mayer, Michael, Sendtner, Albert C, Ludolph, Karin M, Danzer, Christian S, Lobsiger, Axel, Freischmidt, Jochen H, Weishaupt
Publikováno v:
The Journal of Experimental Medicine
This study shows that mice with an ALS-linked heterozygous Tbk1 deletion are normal until at least 200 d of age. However, proteostatic and neuroinflammatory challenge by additional expression of mutant SOD1 unmasks a two-edged role of TBK1 in motoneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cff68ce58f109cc90e62afd738049de
https://pubmed.ncbi.nlm.nih.gov/30635357
https://pubmed.ncbi.nlm.nih.gov/30635357
Autor:
Karin M Danzer, Karlheinz Holzmann, Susanne Petri, Jens Michaelis, Markus Otto, Sarah J Brockmann, Jochen H. Weishaupt, Axel Freischmidt, Albert C. Ludolph, David A. Brenner, Peter M. Andersen, Dietmar Rudolf Thal, Joerg Reinders, Steffen Just, Anika M. Helferich, Dhruva Deshpande
Publikováno v:
Cellular and molecular life sciences : CMLS. 75(23)
Genetic and functional studies suggest diverse pathways being affected in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about converging disease mechanisms is rare. We detected a downregulation of microRNA-1825 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c5eebb27dd28c0abdb9fb1433fe2dc
https://pubmed.ncbi.nlm.nih.gov/30030593
https://pubmed.ncbi.nlm.nih.gov/30030593