Zobrazeno 1 - 10
of 542
pro vyhledávání: '"J, Botelho"'
Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner
Autor:
Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intracell
Externí odkaz:
https://doaj.org/article/1e3be32373c04a07bd765b1eb467c51c
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105883- (2023)
Summary: Ultrasound-stimulated microbubble (USMB) treatment is a promising strategy for cancer therapy. USMB promotes drug delivery by sonoporation and enhanced endocytosis, and also impairs cell viability. However, USMB elicits heterogeneous effects
Externí odkaz:
https://doaj.org/article/99b6f6c8cfa5494fbaea15f56939ff51
Autor:
Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronavi
Externí odkaz:
https://doaj.org/article/6fc7b459daf94a499be2325b0bbff79f
Autor:
M. A. Cavacas, A. Pereira, V. Braz de Oliveira, M. Remédios, A. R. Cavacas, R. Gancho, F. Pimenta, J. Botelho, P. Henriques, G. Borrecho, P. Oliveira, J. Camisão, M. E. Marques, J. J. Mendes
Publikováno v:
Annals of Medicine, Vol 53, Iss sup1, Pp S80-S80 (2021)
AbstractIntroduction Histology knowledge is important to medical sciences as well as an important support to understand the pathology. However, teachers and students feel the need for innovative methods for teaching normal histology [1]. The project
Externí odkaz:
https://doaj.org/article/3cc9003d084446dc89d4fa276da3ac61
Autor:
Golam T Saffi, Evan Tang, Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena, Roberto J Botelho
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259313 (2021)
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates. Thu
Externí odkaz:
https://doaj.org/article/2e13202baa35471ea147821ba54376ff
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa damages hosts through the production of diverse secreted products, many of which are regulated by quorum sensing (QS). The lasR gene, which encodes a central QS regulator, is frequently mutat
Externí odkaz:
https://doaj.org/article/320a205c41bd4f94abb18eded7017f7e
Autor:
Victoria E B Hipolito, Jacqueline A Diaz, Kristofferson V Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Saric, Shannon Mclaughlan, Ola Larsson, Ivan Topisirovic, Roberto J Botelho
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000535 (2019)
The mechanisms that govern organelle adaptation and remodelling remain poorly defined. The endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, and autophagy. For phagocytes, endosomes and lysosomes (endo-lys
Externí odkaz:
https://doaj.org/article/f9af41199bcf4e5b85ff1f3c2ec9827e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Lysosomes are the terminal degradative compartment of autophagy, endocytosis and phagocytosis. What once was viewed as a simple acidic organelle in charge of macromolecular digestion has emerged as a dynamic organelle capable of integrating cellular
Externí odkaz:
https://doaj.org/article/df4541f3f0b640beb2f578192c78bbf7
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