Zobrazeno 1 - 10
of 57
pro vyhledávání: '"J, Bompart"'
Autor:
T. M. Pocock, J. P. Chapat, Karine Portet, Guy Subra, Pierre-Antoine Bonnet, Alain Michel, Veronique Benezech, Olivier Vitse, Lahcen Zanik, Roger C. Small, F. Laurent, Keith R.F. Elliott, J. Bompart
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1059-1065
New imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions. The presence of electron donating groups on position 8 greatly enhances the reactivity of the heterocycle towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d711c5a72f26437b781d44251ae82f26
https://doi.org/10.1016/s0968-0896(99)00019-x
https://doi.org/10.1016/s0968-0896(99)00019-x
Autor:
M Adenot, Veronique Benezech, Pierre-Antoine Bonnet, Jean-Pierre Chapat, Gérard Grassy, J. Bompart
Publikováno v:
European Journal of Medicinal Chemistry. 32:493-504
Summary In order to define some predictive rules for the discrimination of adenosine antagonists by their A1-receptor affinity, we performed a systematic QSAR analysis. As no significant descriptors of affinity were found, we then proposed to introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cccacfd4d1b975a7d204a1e1226c171e
https://doi.org/10.1016/s0223-5234(97)84012-3
https://doi.org/10.1016/s0223-5234(97)84012-3
Autor:
H. Viols, J. P. Chapat, J. Bompart, Guy Subra, Gérard Grassy, Olivier Vitse, Pierre-Antoine Bonnet
Publikováno v:
Journal of Heterocyclic Chemistry. 34:701-707
Nitration was carried out on a series of imidazo[1,2-a]pyrazine derivatives. The reactivities of diversely substituted derivatives and of all positions of substitution were analysed and experimental results compared with 13-nmr data and semi empirica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ba81d461c2240dd6779e055a91e346
https://doi.org/10.1002/jhet.5570340301
https://doi.org/10.1002/jhet.5570340301
Autor:
Veronique Benezech, Gérard Grassy, Jean-Pierre Chapat, Daniel Lafitte, J. Bompart, B. Calas, Pierre-Antoine Bonnet, F. Laurent
Publikováno v:
Journal of Mass Spectrometry. 32:87-93
Electrospray ionization mass spectrometry (ESIMS) was used to study the weak non-covalent interactions occurring between 6-bromo-3-(hydroxymethyl)-8-(methylamino)imidazo [1,2-a]pyrazine (1) and calmodulin. The formation of a 2:1 (ligand: protein) com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19de4fe28c1bd5ee4502146475549b01
https://doi.org/10.1002/(sici)1096-9888(199701)32:1<87::aid-jms460>3.0.co
https://doi.org/10.1002/(sici)1096-9888(199701)32:1<87::aid-jms460>3.0.co
Autor:
P A, Bonnet, O, Vitse, V, Bénezech, G, Subra, J R, Fabréguettes, L, Zanik, F, Laurent, A, Michel, J, Bompart, J P, Chapat
Publikováno v:
Annales pharmaceutiques francaises. 56(4)
Asthma is a complex disease characterised by bronchoconstriction and airways inflammation. Recent advances in medicinal chemistry will surely lead to a better reappraisal of therapeutic strategies. 8-(Methylamino)imidazo(1,2-a)pyrazines with substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5172f29270ed06bcbe8f6ae4141956b3
https://pubmed.ncbi.nlm.nih.gov/9770008
https://pubmed.ncbi.nlm.nih.gov/9770008
Publikováno v:
Journal of molecular graphics. 13(6)
Fifty-four steroid homologs, belonging to the series of 17-spirolactones, were modelled by molecular and quantum mechanics. We studied the affinity of these compounds for the cytosolic mineralocorticoid receptor by way of various parameters describin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e55fa00ccd4e3f8b02f75f71745dfe5
https://pubmed.ncbi.nlm.nih.gov/8820304
https://pubmed.ncbi.nlm.nih.gov/8820304
Autor:
Pierre-Antoine Bonnet, Jean-Pierre Chapat, K. Hadj-Kaddour, Alain Michel, F. Laurent, Maurice Boucard, J. Bompart
1. Experiments have been performed to investigate the cardiovascular actions in the rat of SCA40, a novel potassium channel opener which is a potent relaxant of guinea-pig airway smooth muscle in vivo and in vitro. 2. SCA40 (0.01-30 microM) caused a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e886b7cdfcf216a06856de7af43f0421
https://europepmc.org/articles/PMC2175828/
https://europepmc.org/articles/PMC2175828/
Publikováno v:
Comptes rendus des seances de la Societe de biologie et de ses filiales. 187(4)
Experiments have been performed in order to analyse the mechanism whereby SCA40, a new imidazo[1,2-a]pyrazine derivative relaxes airway smooth muscle. We investigated the effect of different toxins, known to be K(+)-channel blockers on guinea-pig smo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b899fcc0a931d176f8e56bbfe1575d95
https://pubmed.ncbi.nlm.nih.gov/7517337
https://pubmed.ncbi.nlm.nih.gov/7517337
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 45:1983-1986
C 10 H 8 ClNO 3 S cristallise dans P1 avec a=18,110, b=9,076 et c=7,271 A, α=111,29, β=100,10 et γ=94,75 o , Z=4; affinement jusqu'a R=0,049. Le compose etudie, un puissant antibacterien, appartient a la famille des quinolones. Les longueurs de li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42e92f888680245964be5ee2cdbf361
https://doi.org/10.1107/s0108270189004038
https://doi.org/10.1107/s0108270189004038
Publikováno v:
Annales pharmaceutiques francaises. 46(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee83fe420ade8e82258977c9201b05e2
https://pubmed.ncbi.nlm.nih.gov/3256264
https://pubmed.ncbi.nlm.nih.gov/3256264