Zobrazeno 1 - 10
of 128
pro vyhledávání: '"J, Beleta"'
Autor:
Luisa Berto, V. Villagrasa, Miguel Martí-Cabrera, Julio Cortijo, R. Pons, T Domenech, M. Martinez-Losa, J Beleta, Esteban J. Morcillo
Publikováno v:
British Journal of Pharmacology. 127:1641-1651
Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. Glaucine selectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656457c1de92e99ee7871744bfa5d23e
https://doi.org/10.1038/sj.bjp.0702702
https://doi.org/10.1038/sj.bjp.0702702
Publikováno v:
ChemInform. 27
Second messengers are intracellular substances whose concentration is regulated by the action on their specific receptors of extracellular regulatory molecules globally known as first messengers. In particular, the cyclic nucleotides cAMP and cGMP he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f470fe27b383d18591b4fe39cac1d0
https://doi.org/10.1002/chin.199622167
https://doi.org/10.1002/chin.199622167
Autor:
J. Beleta, Guadalupe Mengod, Fumiaki Mori, J.M. Palacios, Andrea Porzionato, S. Pérez-Torres, R. De Caro, A. Gavaldà, Veronica Macchi
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Phosphodiesterase 4 (PDE4) inhibitors, i.e. rolipram, are being extensively investigated as therapeutic agents in several diseases. Emesis is one of the most common side effects of PDE4 inhibitors. Given the fact that the area postrema is considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d6b4aafffd24c82f629e187ab9290d
http://hdl.handle.net/11577/2425330
http://hdl.handle.net/11577/2425330
Autor:
M, Amat, C F, Benjamim, L M, Williams, N, Prats, E, Terricabras, J, Beleta, S L, Kunkel, N, Godessart
Publikováno v:
British journal of pharmacology. 149(6)
The chemokine receptor CCR1 is a potential target for the treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental arthritis and the underlying mechanisms, we used J-113863, a non-peptide antagonist of the mouse recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9352cf830010f6706c73285a77a82c5a
https://pubmed.ncbi.nlm.nih.gov/17016504
https://pubmed.ncbi.nlm.nih.gov/17016504
Autor:
M I, Crespo, J, Gràcia, C, Puig, A, Vega, J, Bou, J, Beleta, T, Doménech, H, Ryder, V, Segarra, J M, Palacios
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(23)
A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b252926ee90e2624bad7a3bb1c527a6
https://pubmed.ncbi.nlm.nih.gov/11128646
https://pubmed.ncbi.nlm.nih.gov/11128646
Autor:
H. Ryder, Gemma Puigbó, J. Beleta, Victor Segarra, Josep Bonjoch, J.M. Palacios, Faïza Diaba, Daniel Solé, L. Santamarı́a
Publikováno v:
Bioorganicmedicinal chemistry. 7(12)
The synthesis of an azaspirocyclic analogue of FR901483, phosphate 2, is described based on the implementation of a key 5-endo aminocyclization promoted by iodine for direct functionalization of the 1-azaspiro[4.5]decane ring at the C-3 atom. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2893c3f14ee96c1296c43296252bed59
https://pubmed.ncbi.nlm.nih.gov/10658593
https://pubmed.ncbi.nlm.nih.gov/10658593
Autor:
V. Segarra, J. Beleta, M. I. Crespo, J. M. Palacios, M. López, T. Domenech, H. Ryder, J. Gràcia
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
The interest in therapeutic utility of PDE inhibitors is mostly focused on new agents which selectively inhibit the PDE4 family1. This subtype of phosphodiesterase is found in both respiratory smooth muscle and circulatory inflammatory cells. Its inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53b796b6ec019933ca872b34e760b5a
https://doi.org/10.1007/978-1-4615-4141-7_48
https://doi.org/10.1007/978-1-4615-4141-7_48
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(8)
Adenosine is produced during inflammation and modulates different functional activities in macrophages. In murine bone marrow-derived macrophages, adenosine inhibits M-CSF-dependent proliferation with an IC50 of 45 microM. Only specific agonists that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::456ce15c90ef638afde3fd82c37062c1
https://pubmed.ncbi.nlm.nih.gov/10510349
https://pubmed.ncbi.nlm.nih.gov/10510349
Autor:
J, Cortijo, V, Villagrasa, R, Pons, L, Berto, M, Martí-Cabrera, M, Martinez-Losa, T, Domenech, J, Beleta, E J, Morcillo
Publikováno v:
British journal of pharmacology. 127(7)
1. Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. 2. Glaucine select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3076f847bcd427614675c2cc7d902566
https://pubmed.ncbi.nlm.nih.gov/10455321
https://pubmed.ncbi.nlm.nih.gov/10455321
Publikováno v:
British journal of pharmacology. 123(6)
1. The responses of the electrically-driven right ventricle strip of the guinea-pig heart to diazepam were recorded in the absence and in the presence of different selective cyclic nucleotide phosphodiesterase (PDE) inhibitors. 2. Diazepam, at concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a48910dd6dd8d6f7308127ef836886e
https://pubmed.ncbi.nlm.nih.gov/9559885
https://pubmed.ncbi.nlm.nih.gov/9559885