Zobrazeno 1 - 10
of 878
pro vyhledávání: '"J, Beech"'
Autor:
Laura J. Brylka, Assil-Ramin Alimy, Miriam E. A. Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J. Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A. Yorgan, Tim Rolvien, Thorsten Schinke
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is
Externí odkaz:
https://doaj.org/article/a1586c2aa5be4762bf608a21489eff44
Autor:
Katherine Norman, Karen E Hemmings, Heba Shawer, Hollie L Appleby, Alan J Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M Woodhouse, David J Beech, Richard Foster, Marc A Bailey
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296065 (2024)
Calcium (Ca2+) is a key second messenger in eukaryotes, with store-operated Ca2+ entry (SOCE) being the main source of Ca2+ influx into non-excitable cells. ORAI1 is a highly Ca2+-selective plasma membrane channel that encodes SOCE. It is ubiquitousl
Externí odkaz:
https://doaj.org/article/9a32393d1f0845708635e76c1981aa12
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115672- (2023)
In intestinal smooth muscle cells, receptor-operated TRPC4 are responsible for the majority of muscarinic receptor cation current (mICAT), which initiates cholinergic excitation-contraction coupling. Our aim was to examine the effects of the TRPC4 in
Externí odkaz:
https://doaj.org/article/96d674eac48e42afbf777a4d68942345
Autor:
Eulashini Chuntharpursat-Bon, Oleksandr V. Povstyan, Melanie J. Ludlow, David J. Carrier, Marjolaine Debant, Jian Shi, Hannah J. Gaunt, Claudia C. Bauer, Alistair Curd, T. Simon Futers, Paul D. Baxter, Michelle Peckham, Stephen P. Muench, Antony Adamson, Neil Humphreys, Sarka Tumova, Robin S. Bon, Richard Cubbon, Laeticia Lichtenstein, David J. Beech
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
The PIEZO1 channel and the PECAM1 cell adhesion molecule interact and PIEZO1 cooperates with PECAM1 and CDH5 cell junctions during mechanical stress.
Externí odkaz:
https://doaj.org/article/ec77feaa25314fbeac8b7a91697307ac
Autor:
Alison J. Beech, Sharon E. Weinberg, Alice E. Mortimer, Fiona Lynch, James Bedford, Giorgio Calisti
Publikováno v:
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 32, Iss , Pp 100381- (2023)
Medical tourism is becoming increasingly popular. The most popularly sought operations are cosmetic procedures. With the increase in cosmetic tourism, it is unsurprising that there has also been a rise in skin and soft tissue infections caused by non
Externí odkaz:
https://doaj.org/article/18779342b2d841aa97989d76921acc53
Publikováno v:
Reproduction and Fertility, Vol 4, Iss 1, Pp 1-3 (2023)
Friction caused by blood flowing across cells that line blood vessels (endothelial cells) activates sensors of mechanical force. This produces nitric oxide (NO) which widens placental blood vessels, enabling more blood flow to the baby. This study so
Externí odkaz:
https://doaj.org/article/3936b8d22f3d4d38b043fb302c302c7e
Autor:
Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, Lara C. Morley, T. Simon Futers, Piruthivi Sukumar, T. Scott Bowen, Mark T. Kearney, Laeticia Lichtenstein, Lee D. Roberts, David J. Beech
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 i
Externí odkaz:
https://doaj.org/article/7a5506da60ec4fa4ab0afb685437f3d2
Autor:
David J. Wright, Katie J. Simmons, Rachel M. Johnson, David J. Beech, Stephen P. Muench, Robin S. Bon
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Wright et al. report the first structure of a human TRPC1/4/5 channel in complex with a xanthine-based TRPC5 inhibitor Pico145. They find that Pico145 binds to a conserved lipid binding site of TRPC5, where it displaces a phospholipid. This study pro
Externí odkaz:
https://doaj.org/article/a4fe404129504c4c9fa1e7487c3b639e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent, arranged circumferentially in one or more layers within blood vessel walls. Remodelling of native VSMC to a proliferative state for vascular development, adapta
Externí odkaz:
https://doaj.org/article/18b587ef040848e0b8635a4206cc25fe
Autor:
Fiona Bartoli, Elizabeth L. Evans, Nicola M. Blythe, Leander Stewart, Eulashini Chuntharpursat-Bon, Marjolaine Debant, Katie E. Musialowski, Laeticia Lichtenstein, Gregory Parsonage, T. Simon Futers, Neil A. Turner, David J. Beech
Publikováno v:
Cells, Vol 11, Iss 7, p 1199 (2022)
PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS), a type of anaemia, due to abnormal red blood cell function. Here, we hypoth
Externí odkaz:
https://doaj.org/article/932ca224765f4a809c1c748ab19616bf