A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy

Autor: Stéphane J. Baudouin, April R. Giles, Nick Pearson, Severine Deforges, Chenxia He, Céline Boileau, Nicolas Partouche, Andreas Borta, Justine Gautron, Morgane Wartel, Irena Bočkaj, Didier Scavarda, Fabrice Bartolomei, Guillaume Penchet, Jérôme Aupy, Jennifer Sims, Jared Smith, Andrew Mercer, Olivier Danos, Christophe Mulle, Valérie Crépel, Richard Porter

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101342- (2024)

Mesial temporal lobe epilepsy (mTLE) is the most prevalent type of epilepsy in adults. First and subsequent generations of anti-epileptic therapy regimens fail to decrease seizures in a large number of patients suffering from mTLE, leaving surgical a

Externí odkaz: https://doaj.org/article/b7eefb3836e346488c8327be3214fc97

Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex

Autor: Stéphane J. Baudouin, Blanca Paramo, Sven O. Bachmann, Isabel Martinez-Garay, Alun M. Davies

Publikováno v: eNeuro

The regulation of neuronal soma size is essential for appropriate brain circuit function and its dysregulation is associated with several neurodevelopmental disorders. A defect in the dendritic growth and elaboration of motor neocortical pyramidal ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd3fec3c6e1c313b03af872b6ca7c16
http://europepmc.org/articles/PMC8114872

Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders

Autor: Stéphane J. Baudouin, James C. Galloway, Monika Sledziowska

Publikováno v: Neuroscience. 445

Autism Spectrum Disorders (ASD) are characterized by heterogeneity both in their presentation and their genetic aetiology. In order to discover points of convergence common to different cases of ASD, attempts were made to identify the biological path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73758664f48a3f58331f35354f93a34b
https://pubmed.ncbi.nlm.nih.gov/31705895

Protein pheromone MUP20/Darcin is a vector and target of indirect genetic effects in mice

Autor: Ellen Cross, Stéphane J. Baudouin, Matthew A. Sarraf, Shireene Kalbassi, Sven O. Bachmann

Social behavior in animals is an adaptive process influenced by environmental factors and direct and indirect genetic effects. Indirect genetic effects (IGEs) include mechanisms by which individuals of particular genotypes can influence the behaviora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df203a860301a2d1b7707e1576a2991

Wortformen und selbst sätze, welche in der polnischen sprache zu stämmen herabgesunken sind

Autor: de Courtenay, J. Baudouin

Publikováno v: Beiträge zur vergleichenden Sprachforschung auf dem Gebiete der arischen, celtischen und slawischen Sprachen, 1870 Jan 01. 6(2), 204-210.

Externí odkaz: https://www.jstor.org/stable/45280481