Risk of emergency hospital admission related to adverse events after antibiotic treatment in adults with a common infection: impact of COVID-19 and derivation and validation of risk prediction models

Autor: Xiaomin Zhong, Victoria Palin, Darren M. Ashcroft, Ben Goldacre, Brian MacKenna, Amir Mehrkar, Sebastian C. J. Bacon, Jon Massey, Peter Inglesby, the OpenSAFELY collaborative, Kieran Hand, Alexander Pate, Tjeerd Pieter van Staa

Publikováno v: BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background With the global challenge of antimicrobial resistance intensified during the COVID-19 pandemic, evaluating adverse events (AEs) post-antibiotic treatment for common infections is crucial. This study aims to examines the changes in

Externí odkaz: https://doaj.org/article/d2de836dfd2942c48582c4365c43915b

Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP

Autor: Andrew Steptoe, John Macleod, Daniel McCartney, Aziz Sheikh, Annie Herbert, Ben Goldacre, David Evans, Louise Jones, Sam Harper, Michael Green, Nicholas Timpson, John Wright, Liam Smeeth, Laurie A Tomlinson, Sinead Brophy, Kate Tilling, Andy Gibson, Paola Zaninotto, Stefan Neubauer, Yinghui Wei, Betty Raman, Chloe Park, Alun Hughes, Jonathan Sterne, Elena Lukaschuk, Stefan Piechnik, Angela Wood, Mark Green, Agnieszka Lemanska, Krishnan Bhaskaran, Kathryn Willan, Elsie Horne, Hannah Woodward, Ian Douglas, Andrew Wong, Andy Boyd, Harriet Forbes, Sinéad Langan, Nishi Chaturvedi, Tom Palmer, Kathryn Mansfield, Rachel Denholm, Emily Herrett, Kevin Wang, Bo Hou, Felix Greaves, Laura Sheard, Praveetha Patalay, Kishan Patel, Jessica Morley, Bang Zheng, Charlotte Booth, Spiros Denaxas, Brian MacKenna, Ruth E Costello, Jonathan Kennedy, William Hulme, Michael Parker, Geneviève Cezard, Syed A Shah, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, Laurie Tomlinson, John Parry, Frank Hester, Eoin McElroy, Amelia Green, Gillian Santorelli, Alisia Carnemolla, Richard Shaw, Samantha Ip, Venexia Walker, Emma L Turner, Richard Thomas, Rebecca Rhead, Archie Campbell, Ellen Thompson, Ruth Bowyer, Jane Maddock, Helen Curtis, Alex Walker, Olivia Hamilton, Rosie McEachan, Ellena Badrick, Stephen Smith, Richard Dobson, Stela McLachlan, Vanessa Ferreira, Vittal Katikireddi, Scott Walker, Lucy Teece, Simon Davy, John Tazare, Bettina Moltrecht, Theocharis Kromydas, Giorgio Di Gessa, Gareth Griffith, Viyaasan Mahalingasivam, Elizabeth Tunnicliffe, George Hickman, Tom Ward, Rebecca M Smith, Sam Parsons, Callum Stewart, Amos Folarin, Daniel Kopasker, Claire Steves, Louis Fisher, Sebastian C J Bacon, Lisa Hopcroft, Robin Y Park, Jon Massey, Iain Dillingham, Steven Maude, Wels Jacques, Linda Nab, Christopher Bates, Milan Wiedemann, Ruth Mitchell, Chao Fang, Fatima Almaghrabi, Jingmin Zhu, Lucy Bridges, Kurt Taylor, Colm Andrews, Jean Stafford, Nathan Cheetham, Sebastian CJ Bacon, Alicja Rapala, Robin Flaig, Andrea L Schaffer, Benjamin FC Butler-Cole, Liam Hart Ben Goldacre, Thomas O’Dwyer, Dylan Williams, Anika Knueppel, Katharine M Evans, Samantha Berman, Matthew Crane, Rebecca Whitehorn, Jacqui Oakley, Diane Foster, Kirsteen C Campbell, Alex Kwong, Ana Goncalves Soares, Renin Toms, Lizzie Huntley, Laura Fox, Rochelle Knight, Northstone Kate, Kanagaratnam Arun, Teri North, Marwa AL Arab, Jose IC Coronado, Arun S Karthikeyan, Ploubidis George, Bozena Wielgoszewska, Charis Bridger-Staatz, Paz Garcia, Maxim Freydin, Amy Roberts, Alex Walker Ben Goldacre, Jess Morley, Anoop Shah Richard Silverwood, Thomas Cowling, Kate Mansfield, Tiffany Yang, Tom Bolton, Alexia Sampri, Elena Rafeti, Robert Willans, Fiona Glen, Steve Sharp, Lee Hamill Howes, Lidia Nigrelli, Fintan McArdle, Chelsea Beckford, Yatharth Ranjan, Jd Carpentieri, Sarah Baz, John Kellas, Laura C Saunders, James M Wild, Peter Jezzard, Zeena-Britt Sanders, Lucy Finnigan, Milla Kibble, Francisco Perez-Reche, Dominik Piehlmaier, Edward Parker

Publikováno v: BMJ Open, Vol 14, Iss 7 (2024)

Objectives Long-term sickness absence from employment has negative consequences for the economy and can lead to widened health inequalities. Sick notes (also called ‘fit notes’) are issued by general practitioners when a person cannot work for he

Externí odkaz: https://doaj.org/article/1038a096d89044e5a8996a5c8992b394

The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England

Autor: Ya-Ting Yang, Xiaomin Zhong, Ali Fahmi, Simon Watts, Darren M. Ashcroft, Jon Massey, Louis Fisher, Brian MacKenna, Amir Mehrkar, Sebastian C. J. Bacon, Ben Goldacre, Kieran Hand, Tjeerd van Staa, Victoria Palin

Publikováno v: Antimicrobial Resistance and Infection Control, Vol 12, Iss 1, Pp 1-18 (2023)

Abstract Background There is concern that the COVID-19 pandemic altered the management of common infections in primary care. This study aimed to evaluate infection-coded consultation rates and antibiotic use during the pandemic and how any change may

Externí odkaz: https://doaj.org/article/a8db20df2fb5467d8ed9caa425eaed98

Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings: retrospective, descriptive cohort study of 23.4 million people in OpenSAFELY

Autor: Ben Goldacre, David Evans, Sam Harper, Orla Macdonald, Alex J Walker, Richard Croker, William J Hulme, Colm D Andrews, Laurie A Tomlinson, Krishnan Bhaskaran, Henry Drysdale, Nicholas J DeVito, Ian J Douglas, Caroline E Morton, Jessica Morley, Bang Zheng, Brian MacKenna, Stephen J W Evans, Christopher T Rentsch, Helen J Curtis, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, John Parry, Frank Hester, Rose Higgins, Simon Davy, John Tazare, Viyaasan Mahalingasivam, George Hickman, Tom Ward, Rebecca M Smith, Amelia C A Green, Louis Fisher, Sebastian C J Bacon, Robin Y Park, Jon Massey, Iain Dillingham, Linda Nab, Christopher Bates, Lisa E M Hopcroft, Milan Wiedemann

Publikováno v: BMJ Medicine, Vol 2, Iss 1 (2023)

Objective To ascertain patient eligibility status and describe coverage of antiviral drugs and neutralising monoclonal antibodies (nMAB) as treatment for covid-19 in community settings in England.Design Retrospective, descriptive cohort study, approv

Externí odkaz: https://doaj.org/article/a60fb92626de4ac3ad60f635c2d29cc2

Toxicity of zoledronic acid after intravenous administration: A retrospective study of 95 dogs

Autor: David John Brewer, Michael Macfarlane, Erin O'Connell, Nicholas J. Bacon

Publikováno v: Journal of Veterinary Internal Medicine, Vol 36, Iss 1, Pp 253-258 (2022)

Abstract Background There is a paucity of veterinary literature on the safety or outcome of zoledronic acid (ZA) use in dogs for either bone pain or hypercalcemia. Hypothesis/Objectives The primary aim was to report the adverse events in dogs receivi

Externí odkaz: https://doaj.org/article/4c3579df6ffd45c3ab3339eebc82e4b5