Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Izzy Jayasinghe"'
Autor:
Miriam E. Hurley, Shihab S. Shah, Thomas M. D. Sheard, Hannah M. Kirton, Derek S. Steele, Nikita Gamper, Izzy Jayasinghe
Publikováno v:
Cells, Vol 13, Iss 1, p 38 (2023)
Coordinated events of calcium (Ca2+) released from the endoplasmic reticulum (ER) are key second messengers in excitable cells. In pain-sensing dorsal root ganglion (DRG) neurons, these events can be observed as Ca2+ sparks, produced by a combination
Externí odkaz:
https://doaj.org/article/ed1be321deb1400ab073fea9567ebdb9
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in excitable cells. In the heart, rapid summation of the elementary events of calcium release, 'calciu
Externí odkaz:
https://doaj.org/article/b38620d58c964e7a883436349b4db563
Autor:
Tanya R. Cully, Robyn M. Murphy, Llion Roberts, Truls Raastad, Robert G. Fassett, Jeff S. Coombes, Izzy Jayasinghe, Bradley S. Launikonis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Abstract High-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane
Externí odkaz:
https://doaj.org/article/ac5dc5c88c904369b9a94eb7648f2c36
Autor:
Izzy Jayasinghe, Alexander H. Clowsley, Oscar de Langen, Sonali S. Sali, David J. Crossman, Christian Soeller
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Remodelling of the membranes and protein clustering patterns during the pathogenesis of cardiomyopathies has renewed the interest in spatial visualisation of these structures in cardiomyocytes. Coincidental emergence of single molecule (super-resolut
Externí odkaz:
https://doaj.org/article/9ec4d5a1c6c044c5b36200a68ee41172
Autor:
Thomas M. D. Sheard, Tayla Shakespeare, Rajpinder S. Seehra, Michael E Spencer, Kin M. Suen, Izzy Jayasinghe
Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for nondescript staining of cellular and tissue architectures. We characterised the differential staining patterns of 14 fluorescent dye ester species with varying phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f481f0cd6e61e45d983722ef3895701c
https://doi.org/10.1101/2023.02.21.529394
https://doi.org/10.1101/2023.02.21.529394
Autor:
Rajpinder S. Seehra, Benjamin H.K. Allouis, Thomas M.D. Sheard, Michael E Spencer, Tayla Shakespeare, Ashley Cadby, Izzy Jayasinghe
Expansion microscopy (ExM) is a versatile super-resolution microscopy pipeline, leveraging nanoscale biomolecular cross- linking and osmotically driven swelling of hydrogels. In its current implementation, ExM remains a laborious and skill-intensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d27c2b0612d2c1b3691532e56206d5
https://doi.org/10.1101/2023.02.20.529230
https://doi.org/10.1101/2023.02.20.529230
Autor:
Thomas M. D. Sheard, Miriam E. Hurley, Andrew J. Smith, John Colyer, Ed White, Izzy Jayasinghe
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 377
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8768e69c07e1c65de75c4cb1a321574
https://doi.org/10.1098/rstb.2021.0316
https://doi.org/10.1098/rstb.2021.0316
Autor:
Fiona Ashford, Elaine Brown, Sarah Calagan, Izzy Jayasinghe, Colin Henderson, William Fuller, Krzysztof Wypijewski
Caveolae are small flask-shaped invaginations of the surface membrane which are proposed to recruit and co-localise signalling molecules. The distinctive caveolar shape is achieved by the oligomeric structural protein caveolin, of which three isoform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd6e7a338f91102fc096398b630abdf
https://doi.org/10.1101/2022.09.15.508083
https://doi.org/10.1101/2022.09.15.508083
Autor:
Kin M. Suen, Thomas M. D. Sheard, Chi-Chuan Lin, Dovile Milonaityte, Izzy Jayasinghe, John E. Ladbury
Many membraneless organelles (MLOs) have been shown to form via liquid-liquid phase separation (LLPS). Light and electron microscopy techniques have been indispensable in the identification and characterization of LLPS MLOs. However, for complex MLOs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566481411290526f4e533cb6724bac88
https://doi.org/10.1101/2022.05.29.493872
https://doi.org/10.1101/2022.05.29.493872
Autor:
Julie M. Jebsen, Cathy Abbott, Rachel Oliver, Erinma Ochu, Izzy Jayasinghe, Caroline Gauchotte-Lindsay
Publikováno v:
Psychology of Women and Equalities Section Review. 3:3-14
In the UK, women are underrepresented at the highest levels of academia in all subjects but nursing, but particularly in science, technology, engineering, and math (STEM) (Advance HE, 2018). Research, and the funding that enables research, is a criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ae4bb32ceb920fff0a210bc49f5ff4
https://doi.org/10.53841/bpspowe.2020.3.1-2.3
https://doi.org/10.53841/bpspowe.2020.3.1-2.3