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Genotypic and Phenotypic Analyses of Hepatitis C Virus from Patients Treated with JTK-853 in a Three-Day Monotherapy

Autor: Kunihiro Hirahara, Gabriela Turcanu, Toru Noguchi, Barbara Gerhardt, Yukiyo Toyonaga, Sudhakar M. Pai, Kan Yee, Maribel Rodriguez-Torres, Tsutomu Shibata, Naoki Ogura, Izuru Ando

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:436-444

JTK-853, a palm site-binding NS5B nonnucleoside polymerase inhibitor, shows antiviral activity in vitro and in hepatitis C virus (HCV)-infected patients. Here, we report the results of genotypic and phenotypic analyses of resistant variants in 24 HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce043270d63d4b0f9f57e5f0974c227
https://doi.org/10.1128/aac.01432-12

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Isolation and gene analysis of interferon α-resistant cell clones of the hepatitis C virus subgenome

Autor: Naoki Ogura, Tohru Noguchi, Tomoko Otsubaki, Satoru Ikeda, Kunitada Shimotohno, Izuru Ando

Publikováno v: Virology. 375:424-432

Hepatitis C virus (HCV) proteins appear to play an important role in IFN-resistance, but the molecular mechanism remains unclear. To clarify the mechanism in HCV replicon RNA harboring Huh-7 cells (Huh-9-13), we isolated cellular clones with impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c34e027309494adc254f82950e03fb0
https://doi.org/10.1016/j.virol.2008.02.009

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Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety

Autor: Yoshinori Hara, Satoru Noji, Satoru Ikeda, Hiroshi Yamanaka, Shintaro Hirashima, Kazutaka Ikegashira, Hiromasa Hashimoto, Yasushi Niwa, Ryo Mizojiri, Toru Noguchi, Takahiro Oka, Izuru Ando, Hiroyuki Goto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:3181-3186

Following the discovery of JTK-109 ( 1 ) as a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase, [(a) Hirashima, S.; Suzuki, T.; Ishida, T.; Noji, S.; Yata, S.; Ando, I.; Komatsu, M.; Ikeda, S.; Hashimoto, H. J. Med. Chem. 2006

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11e7639c944fbb3c6d7112ca415762c
https://doi.org/10.1016/j.bmcl.2007.03.027

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Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Autor: Satoru Ikeda, Hiromasa Hashimoto, Shintaro Hirashima, Tomio Ishida, Izuru Ando, Takayoshi Suzuki, Atsuhito Yoshida, Tsuyoshi Adachi, Mizutani Kenji

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:1859-1863

A series of 1-cycloalkyl-2-phenyl-1H-benzimidazole-5-carboxylic acid derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase (RdRp). A SAR study was performed and led to identify the 2-[(4-diary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f38ee4a8d02efbdc56a9826e8d3647
https://doi.org/10.1016/j.bmcl.2006.01.032

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Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages

Autor: Takao Kataoka, Kazuo Nagai, Sachiko Akashi, Tetsuya Wakabayashi, Izuru Ando, Yoshinori Tsukumo, Kensuke Miyake

Publikováno v: International Immunopharmacology. 2:1155-1162

Two active polysaccharide fractions (SF1 and SF2) purified from dried safflower petals (Carthamus tinctorius L.) stimulated the synthesis of various cytokines by peritoneal macrophages. In a number of cell types, SF1 and SF2 induced a rapid degradati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4027856a813c1d8fd4466108021f41e7
https://doi.org/10.1016/s1567-5769(02)00076-0

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JTK-853, a novel non-nucleoside hepatitis C virus polymerase inhibitor, demonstrates a high genetic barrier to resistance in vitro

Autor: Izuru Ando, Toru Noguchi, Yukiyo Toyonaga, Naoki Ogura, Kunihiro Hirahara, Tsutomu Shibata

Publikováno v: Intervirology. 56(5)

JTK-853 is a novel, non-nucleoside, palm site-binding hepatitis C virus (HCV) polymerase inhibitor that has demonstrated antiviral activity in HCV-infected patients during 3 days of treatment. To estimate the genetic barrier of JTK-853 to resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae032a7080c46b564720020b0a7d8c8
https://pubmed.ncbi.nlm.nih.gov/24008863

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Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

Autor: Yukiyo Toyonaga, Izuru Ando, Kazuyuki Sugimoto, Masafumi Kamada, Toru Noguchi, Naoki Ogura, Tsuyoshi Adachi, Hiroyuki Abe

JTK-853 is a novel piperazine derivative nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase. JTK-853 showed potent inhibitory activity against genotype 1 HCV polymerase, with a 50% inhibitory concentration in the nanomola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9431b46c20e91f50108fa00d9e53c3fe
https://europepmc.org/articles/PMC3421577/

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Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors

Autor: Tsuyoshi Adachi, Yoshinori Hara, Naoki Ogura, Shintaro Hirashima, Hiromasa Hashimoto, Tsuruha Junichiro, Kazutaka Ikegashira, Satoru Noji, Hiroshi Yamanaka, Toru Noguchi, Satoru Ikeda, Satoki Doi, Yasunori Hase, Izuru Ando, Takahiro Oka

Publikováno v: Journal of medicinal chemistry. 49(24)

We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6786e63cc76294db660d193aabadbdfe
https://pubmed.ncbi.nlm.nih.gov/17125247

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Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109

Autor: Shintaro Hirashima, Tomio Ishida, Izuru Ando, Takayoshi Suzuki, Satoru Ikeda, Shinji Yata, Masakazu Komatsu, Satoru Noji, Hiromasa Hashimoto

Publikováno v: Journal of medicinal chemistry. 49(15)

Following the discovery of a new series of benzimidazole derivatives bearing a diarylmethyl group as inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp),1,2 we extended the structure-activity relationship (SAR) study to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5636bf7e84cec91070ff6dd3c1cc50
https://pubmed.ncbi.nlm.nih.gov/16854079

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