Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Izumi V. Hinkson"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Conventional drug discovery is long and costly, and suffers from high attrition rates, often leaving patients with limited or expensive treatment options. Recognizing the overwhelming need to accelerate this process and increase success, the ATOM con
Externí odkaz:
https://doaj.org/article/efbc88ba69514c9cba6aa22e3e08b739
Autor:
Izumi V. Hinkson, Tanja M. Davidsen, Juli D. Klemm, Ishwar Chandramouliswaran, Anthony R. Kerlavage, Warren A. Kibbe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 5 (2017)
Externí odkaz:
https://doaj.org/article/c5b7a29730054c189f7d4cff663cd662
Autor:
Izumi V. Hinkson, Tanja M. Davidsen, Juli D. Klemm, Ishwar Chandramouliswaran, Anthony R. Kerlavage, Warren A. Kibbe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 5 (2017)
Advancements in next-generation sequencing and other -omics technologies are accelerating the detailed molecular characterization of individual patient tumors, and driving the evolution of precision medicine. Cancer is no longer considered a single d
Externí odkaz:
https://doaj.org/article/6741549dc2f74eb1aa2e849ca5c0e299
Autor:
Izumi V. Hinkson, Jae K. Ryu, Eva Czirr, Katerina Akassoglou, Nicholas A. Castello, Sasha N. Farina, Nadia P. Belichenko, John R. Cirrito, Markus Britschgi, Kira I. Mosher, Lulin Li, Tony Wyss-Coray, Bernat Baeza-Raja, Joseph M. Castellano, Frank M. Longo, Kurt M. Lucin
Publikováno v:
The Journal of Experimental Medicine
Czirr et al. report that microglia lacking complement receptor 3 display increased extracellular Aβ degrading activity and that targeting the receptor with a small molecule increases Aβ clearance in vivo, thus identifying a microglial receptor as a
Autor:
Jimmy K. Eng, Alexey I. Nesvizhskii, Harryl D. Martinez, Jordy J. Hsiao, Rohini J. Jasavala, Brandon H. Ng, Melinda M. Smits, Damian Fermin, Michael E. Wright, Izumi V. Hinkson
Publikováno v:
Molecular Endocrinology. 29:1195-1218
The aberrant expression of androgen receptor (AR)-dependent transcriptional programs is a defining pathology of the development and progression of prostate cancers. Transcriptional cofactors that bind AR are critical determinants of prostate tumorige
Autor:
Jadon C. Shen, Daniela Berdnik, Xinmin Xie, Izumi V. Hinkson, Bende Zou, Alisha McBride, Michelle L. James, Rachelle J. Abbey, Kira I. Mosher, Martha Tingle, Tony Wyss-Coray, Martin S. Angst, Joseph M. Castellano
Ageing drives changes in neuronal and cognitive function, the decline of which is a major feature of many neurological disorders. The hippocampus, a brain region subserving roles of spatial and episodic memory and learning, is sensitive to the detrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3eeea5b131a43938cd5d8ecac13260
https://europepmc.org/articles/PMC5586222/
https://europepmc.org/articles/PMC5586222/
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005725 (2015)
PLoS Genetics
PLoS Genetics
Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between repro
Autor:
Joshua E. Elias, Izumi V. Hinkson
Publikováno v:
Trends in cell biology. 21(5)
The continual destruction and renewal of proteins that maintain cellular homeostasis has been rigorously studied since the late 1930s. Experimental techniques for measuring protein turnover have evolved to measure the dynamic regulation of key protei
Autor:
Izumi V. Hinkson, Harryl D. Martinez, Rohini J. Jasavala, Latricia D. Fitzgerald, Hsing Jien Kung, James S. Trimmer, Michael E. Wright
Reactivation of the androgen receptor (AR) signaling pathway represents a critical step in the growth and survival of androgen-independent (AI) prostate cancer (CaP). In this study we show the DU145 and PC3 AI human CaP cell lines respond to androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153d0a93e7aff656f26e9b343b485256
https://europepmc.org/articles/PMC2662061/
https://europepmc.org/articles/PMC2662061/