Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Izumi Oinuma"'
Autor:
Takahiko Matsuda, Izumi Oinuma
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract To analyze the expression, localization, and functional dynamics of target proteins in situ, especially in living cells, it is important to develop a convenient, versatile, and efficient method to precisely introduce exogenous genes into the
Externí odkaz:
https://doaj.org/article/f107d8d68d0e403a88d8d8bf7f405aaf
Autor:
Izumi Oinuma, Takahiko Matsuda
Publikováno v:
Molecular Biology of the Cell
Fluorescence imaging at single-cell resolution is a crucial approach to analyzing the spatiotemporal regulation of proteins within individual cells of complex neural networks. Here we present a nonviral strategy that enables the tagging of endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4444bb4b1b1f8df14469ec8f85dcf9bf
https://doi.org/10.1091/mbc.e19-04-0223
https://doi.org/10.1091/mbc.e19-04-0223
Autor:
Izumi Oinuma, Takahiko Matsuda
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
To analyze the expression, localization, and functional dynamics of target proteins in situ, especially in living cells, it is important to develop a convenient, versatile, and efficient method to precisely introduce exogenous genes into the genome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94c27172f6584b17da2b2dd6c3abc25
http://europepmc.org/articles/PMC6683140
http://europepmc.org/articles/PMC6683140
Publikováno v:
Gene. 689
An F-actin scaffold protein, afadin, comprises two splice variants called l-afadin (a long isoform) and s-afadin (a short isoform). It is known that in adult tissues, l-afadin is ubiquitously expressed while s-afadin is restrictedly expressed in brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c91ba7fbb6c2cab9009fd9e791c56
https://pubmed.ncbi.nlm.nih.gov/30572094
https://pubmed.ncbi.nlm.nih.gov/30572094
Publikováno v:
Brain research. 1692
AF6/afadin is an F-actin scaffold protein that plays essential roles in the organization of cell-cell junctions of polarized epithelia. Afadin comprises two major isoforms produced by alternative splicing – a longer isoform l-afadin, having the F-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa2d9c8449d932133ad661405f0ee88
https://pubmed.ncbi.nlm.nih.gov/29733813
https://pubmed.ncbi.nlm.nih.gov/29733813
Publikováno v:
Molecular Biology of the Cell
Suppression of surplus axon branching is crucial for formation of proper neuronal networks; however, the molecular mechanisms have been poorly understood. In a novel mechanism, s-afadin, a short splicing isoform of afadin lacking the F-actin–bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76efcb526433c9117ff40f3fc2d48db1
http://europepmc.org/articles/PMC4436838
http://europepmc.org/articles/PMC4436838
Publikováno v:
Molecular Biology of the Cell
A signaling pathway downstream of R-Ras is identified that controls axon branching in cortical neurons. Besides the well-known role of R-Ras as an activator of the PI3K signaling pathway, a novel system of cytoskeletal regulation is found by which R-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203360015a37bdb1eb3c086e81a61ed
https://doi.org/10.1091/mbc.e12-02-0103
https://doi.org/10.1091/mbc.e12-02-0103
Publikováno v:
Journal of Neuroscience. 32:8293-8305
Semaphorins have been identified as repulsive guidance molecules in the developing nervous system. We recently reported that the semaphorin 4D (Sema4D) receptor Plexin-B1 induces repulsion in axon and dendrites by functioning as a GTPase-activating p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b3ea81b0c17137c47f2aabe89c4e0f
https://doi.org/10.1523/jneurosci.0799-12.2012
https://doi.org/10.1523/jneurosci.0799-12.2012
Publikováno v:
Molecular Biology of the Cell
The N-terminal region is the lipid raft–targeting determinant. A novel regulatory mechanism is found by which Rnd proteins function as RhoA antagonists, as is a striking mechanism by which differential membrane targeting governs activities of G pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeff0c16aaad7ddd61c995911d8ee78
https://doi.org/10.1091/mbc.e11-11-0900
https://doi.org/10.1091/mbc.e11-11-0900
Publikováno v:
EMBO reports. 10:614-621
Plexins are receptors for axonal guidance molecules known as semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, induces axonal growth cone collapse by functioning as an R-Ras GTPase activating protein (GAP). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b38dd9aad5572011eb547e014f8fa8
https://doi.org/10.1038/embor.2009.63
https://doi.org/10.1038/embor.2009.63