Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Izumi Nakagome"'
Autor:
Atsushi Kato, Izumi Nakagome, Mizuki Hata, Robert J. Nash, George W. J. Fleet, Yoshihiro Natori, Yuichi Yoshimura, Isao Adachi, Shuichi Hirono
Publikováno v:
Molecules, Vol 25, Iss 12, p 2843 (2020)
Deoxynojirimycin (DNJ) is the archetypal iminosugar, in which the configuration of the hydroxyl groups in the piperidine ring truly mimic those of d-glucopyranose; DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-diabet
Externí odkaz:
https://doaj.org/article/40f631e564e84a238489d0be7c8c45d9
Autor:
Izumi Nakagome, Atsushi Kato, Noriyuki Yamaotsu, Tomoki Yoshida, Shin-ichiro Ozawa, Isao Adachi, Shuichi Hirono
Publikováno v:
Molecules, Vol 23, Iss 10, p 2683 (2018)
Some point mutations in β-glucocerebrosidase cause either improper folding or instability of this protein, resulting in Gaucher disease. Pharmacological chaperones bind to the mutant enzyme and stabilize this enzyme; thus, pharmacological chaperone
Externí odkaz:
https://doaj.org/article/712cacbe72cb492a9bef6dac5306b771
Autor:
Atsushi Kato, Izumi Nakagome, Uta Kanekiyo, Tian-Tian Lu, Yi-Xian Li, Kosuke Yoshimura, Mana Kishida, Kenta Shinzawa, Tomoki Yoshida, Nobutada Tanaka, Yue-Mei Jia, Robert J. Nash, George W. J. Fleet, Chu-Yi Yu
Publikováno v:
Journal of Medicinal Chemistry. 65:2329-2341
Autor:
Atsushi, Kato, Izumi, Nakagome, Kosuke, Yoshimura, Uta, Kanekiyo, Mana, Kishida, Kenta, Shinzawa, Tian-Tian, Lu, Yi-Xian, Li, Robert J, Nash, George W J, Fleet, Nobutada, Tanaka, Chu-Yi, Yu
Publikováno v:
Organicbiomolecular chemistry. 20(36)
L
Autor:
Shuichi Hirono, Noriyuki Yamaotsu, Izumi Nakagome, Kensuke Misawa, Shin-ichiro Ozawa, Tomoki Yoshida
Publikováno v:
YAKUGAKU ZASSHI. 139:827-835
Proteolysis mediated by the ubiquitin-proteome system plays an important role in cancer. Recently, a deubiquitinating enzyme, ubiquitin-specific protease 7 (USP7) has attracted attention as a key regulator of the p53-human double minute 2 (HDM2) path
Autor:
Izumi Nakagome, Atsushi Kato, Robert J. Nash, Isao Adachi, Yuichi Yoshimura, Yoshihiro Natori, Shuichi Hirono, George W. J. Fleet, Mizuki Hata
Publikováno v:
Molecules
Volume 25
Issue 12
Molecules, Vol 25, Iss 2843, p 2843 (2020)
Volume 25
Issue 12
Molecules, Vol 25, Iss 2843, p 2843 (2020)
Deoxynojirimycin (DNJ) is the archetypal iminosugar, in which the configuration of the hydroxyl groups in the piperidine ring truly mimic those of d-glucopyranose
DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-di
DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-di
Autor:
Izumi Nakagome, Shin-ichiro Ozawa, Noriyuki Yamaotsu, Daichi Hayakawa, Shuichi Hirono, Tomoki Yoshida
Publikováno v:
Biophysical Chemistry. 228:47-54
Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism due to mutations in phenylalanine hydroxylase (PAH). Recently, small compounds, known as pharmacological chaperones (PhCs), have been identified that restore the enzymatic activity
Autor:
Kensuke, Misawa, Shin-Ichiro, Ozawa, Tomoki, Yoshida, Izumi, Nakagome, Noriyuki, Yamaotsu, Shuichi, Hirono
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 139(5)
Proteolysis mediated by the ubiquitin-proteome system plays an important role in cancer. Recently, a deubiquitinating enzyme, ubiquitin-specific protease 7 (USP7) has attracted attention as a key regulator of the p53-human double minute 2 (HDM2) path
Autor:
Quentin P. Roebuck, Shuichi Hirono, Atsushi Kato, Stephen High, Sarah O'Keefe, Robert J. Nash, Izumi Nakagome
Publikováno v:
O'keefe, S, Roebuck, Q P, Nakagome, I, Hirono, S, Kato, A, Nash, R & High, S 2019, ' Characterising the selectivity of ER α-glucosidase inhibitors ', Glycobiology . https://doi.org/10.1093/glycob/cwz029
Glycobiology
Glycobiology
The endoplasmic reticulum (ER) contains both α-glucosidases and α-mannosidases which process the N-linked oligosaccharides of newly synthesized glycoproteins and thereby facilitate polypeptide folding and glycoprotein quality control. By acting as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4870068bce8b2df4c73e9bae743c5ff9
https://www.research.manchester.ac.uk/portal/en/publications/characterising-the-selectivity-of-er-glucosidase-inhibitors(3aa56fb0-c44a-4561-9ebe-a6713d5a277f).html
https://www.research.manchester.ac.uk/portal/en/publications/characterising-the-selectivity-of-er-glucosidase-inhibitors(3aa56fb0-c44a-4561-9ebe-a6713d5a277f).html
Autor:
Noriyuki Yamaotsu, Shuichi Hirono, Atsushi Kato, Isao Adachi, Izumi Nakagome, Shin-ichiro Ozawa, Tomoki Yoshida
Publikováno v:
Molecules
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2683 (2018)
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2683 (2018)
Some point mutations in &beta
glucocerebrosidase cause either improper folding or instability of this protein, resulting in Gaucher disease. Pharmacological chaperones bind to the mutant enzyme and stabilize this enzyme
thus, pharmacologica
glucocerebrosidase cause either improper folding or instability of this protein, resulting in Gaucher disease. Pharmacological chaperones bind to the mutant enzyme and stabilize this enzyme
thus, pharmacologica