Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Izumi Morita"'
Autor:
Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein, comprises positively charged N-terminal, hydrop
Externí odkaz:
https://doaj.org/article/10610d7d92d34ae0ab1fa5b064e5d988
Autor:
Yuki Kiguchi, Hiroyuki Oyama, Izumi Morita, Yasuhiro Nagata, Naoko Umezawa, Norihiro Kobayashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In vitro affinity-maturation potentially generates antibody fragments with enhanced antigen-binding affinities that allow for developing more sensitive diagnostic systems and more effective therapeutic agents. Site-directed mutagenesis targe
Externí odkaz:
https://doaj.org/article/8bb6256cd6294d32b16c979a6b21bdcb
Autor:
Hitoshi Kimura, Shiho Mikawa, Chiharu Mizuguchi, Yuki Horie, Izumi Morita, Hiroyuki Oyama, Takashi Ohgita, Kazuchika Nishitsuji, Atsuko Takeuchi, Sissel Lund-Katz, Kenichi Akaji, Norihiro Kobayashi, Hiroyuki Saito
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Apolipoprotein A-I (apoA-I) undergoes a large conformational reorganization during remodeling of high-density lipoprotein (HDL) particles. To detect structural transition of apoA-I upon HDL formation, we developed novel monoclonal antibodies
Externí odkaz:
https://doaj.org/article/cd93be0f7d85464f8c4243caf236703f
Publikováno v:
Molecules, Vol 15, Iss 9, Pp 6559-6569 (2010)
To search for possible anti-tumor agents or anti-tumor promoters among natural or synthetic products, we used cyclic voltammetry to determine the reduction-oxidation potentials of heterocyclic quinones in phosphate buffer at pH 7.2. We determined the
Externí odkaz:
https://doaj.org/article/741bd05149294ad683e6503f6457024c
Autor:
Izumi Morita, Yuki Kiguchi, Saya Nakamura, Ayano Yoshida, Haruna Kubo, Momo Ishida, Hiroyuki Oyama, Norihiro Kobayashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:851-855
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::820b96623284710cfff5aa6344add663
https://doi.org/10.1248/bpb.b22-00187
https://doi.org/10.1248/bpb.b22-00187
Publikováno v:
Biologicalpharmaceutical bulletin. 45(10)
Previously, we generated high-affinity antibody mutants that enabled sensitive immunoassays by exploring diverse libraries of single-chain Fv fragments (scFvs) displayed on bacteriophage. To isolate rarely-occurring desirable clones, "panning" has co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b874e865badcaa85e485e4b1ecf28d8b
https://pubmed.ncbi.nlm.nih.gov/36184500
https://pubmed.ncbi.nlm.nih.gov/36184500
Autor:
Kouya Yamaki, Kiyoe Ohta, Norihiro Kobayashi, Izumi Morita, Yuki Kiguchi, Hiroyuki Oyama, Ken Ito, Asuka Nanbo, Hirozo Oh-oka, Yutaka Koyama, Yoshiki Kawata, Hirotaka Fujisawa, Mitsuhiro Ohta
Publikováno v:
Biologicalpharmaceutical bulletin. 45(8)
The emu is the second largest ratite; thus, their sera and egg yolks, obtained after immunization, could provide therapeutic and diagnostically important immunoglobulins with improved production efficiency. Reliable purification tools are required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e23ffa2e0f4ed9ba6d7316d9f5267
https://pubmed.ncbi.nlm.nih.gov/35908885
https://pubmed.ncbi.nlm.nih.gov/35908885
Autor:
Izumi Morita, Yuki Kiguchi, Hiroyuki Oyama, Kouya Yamaki, Nami Sakio, Keisuke Kashiwabara, Yumi Kuroda, Aya Ito, Asaka Yokota, Natsumi Ikeda, Ruri Kikura-Hanajiri, Hiroshi Ueda, Satoshi Numazawa, Takemi Yoshida, Norihiro Kobayashi
Publikováno v:
Analytical methods : advancing methods and applications. 14(28)
Chemical derivatization into larger molecules has generated a monoclonal antibody that enables group-specific immunochemical detection of potent methamphetamine and amphetamine enantiomers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de73a0289c894c94c2279e20092ff8
https://pubmed.ncbi.nlm.nih.gov/35785801
https://pubmed.ncbi.nlm.nih.gov/35785801
Autor:
Yuki Kiguchi, Hiroyuki Oyama, Chisato Tode, Norihiro Kobayashi, Izumi Morita, Ruri Kikura-Hanajiri, Atsuko Takeuchi, Jun Ogata, Rie Tanaka
Publikováno v:
Analytical Methods. 13:3954-3962
A sensitive immunochemical method for identifying hallucinogenic mushrooms (magic mushrooms) is required for regulating their illicit use. We have previously generated a monoclonal antibody (mAb) that targets psilocin (Psi), the major psychoactive co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044ecdb34bea1adb61e25533dba81cf3
https://doi.org/10.1039/d1ay01157j
https://doi.org/10.1039/d1ay01157j
Autor:
Yuki Furutani, Hiroyuki Saito, Kazuchika Nishitsuji, Sera Naniwa, Megumi Hattori, Takashi Ohgita, Hiroyuki Oyama, Miyu Nakano, Izumi Morita, Miho Nakagawa, Ayane Suzuki, Norihiro Kobayashi
Publikováno v:
The FEBS Journal. 288:1496-1513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23b71ba9e826daccf84e1b19c9b8c7f
https://doi.org/10.1111/febs.15487
https://doi.org/10.1111/febs.15487