Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Izumi Komiya"'
Autor:
Izumi, Komiya, Yuki, Asaba
Publikováno v:
GR-同志社大学グローバル地域文化学会紀要 = Doshisha Global and Regional Studies Review. 20:75-109
ローカルな文脈の正統性と国際的な介入の関係は、アフガニスタンへの介入の失敗をきっかけにクローズアップされるようになった。本稿では、紛争を解決し、現地の人々から見て長期
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::19079390773b1ed8bf8a67ac88aa012f
http://id.nii.ac.jp/1707/00029548/
http://id.nii.ac.jp/1707/00029548/
Publikováno v:
Progress in Nuclear Energy. 50:719-727
In order to study the following two points, we conducted an attitude survey among senior high school students. Study 1 The differences in attitudes between nuclear power generation and other science and technologies. Study 2 The relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d1aaf2334468c667af1f8bab8874cf
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100822564
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100822564
Autor:
Shigeki Shibasaki, Izumi Komiya
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 31:255-260
Cerebrospinal fluid (CSF) concentrations of quinolone antibiotics in humans, which may be related to CNS adverse effects and quinolone antibiotic-induced convulsions, were predicted from parameters for penetration into the CSF (CSF-to-unbound plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46864d7c0671064219749a1a6e20cb21
https://doi.org/10.5649/jjphcs.31.255
https://doi.org/10.5649/jjphcs.31.255
Publikováno v:
Chemico-Biological Interactions. 148:139-147
Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminogly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121f60937bbf7e75901d97ec9fafcfa6
https://doi.org/10.1016/j.cbi.2004.05.005
https://doi.org/10.1016/j.cbi.2004.05.005
Publikováno v:
Pharmaceutical Research. 18:439-445
Purpose. Pivalic acid (PVA) forms conjugates with endogenous carnitine and enhances its excretion. The purpose of this study is to determine whether tissue carnitine levels decrease in parallel with plasma levels in carnitine deficiency induced by PV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ea3273bcb40d936738cf24bd5b8dec
https://doi.org/10.1023/a:1011042008169
https://doi.org/10.1023/a:1011042008169
Publikováno v:
Biopharmaceutics & Drug Disposition. 14:443-454
The respiratory depression effect of aminoglycoside antibiotics was studied by a toxicokinetic approach, and species differences in drug susceptibility were elucidated based on plasma concentrations. An allometric relationship was obtained between to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a6e6f1aeb22a54640c02e7b10181bf
https://doi.org/10.1002/bdd.2510140510
https://doi.org/10.1002/bdd.2510140510
Autor:
Hideaki Seki, Kumiko Kawano, Yoshio Esumi, Izumi Komiya, Takashi Matsumoto, Kazue Kimura, Koichi Mitsugi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 7:787-797
After oral administration of (pivaloyloxymethyl-14C) ME1207 to rats, the radioactivity derived from the oxymethylene moiety in the ester group was well absorbed and the absorption extent was more than 90% of administered dose. The radioactivity was m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cd8c2c1ac0d8606243cf3e75568eba8
https://doi.org/10.2133/dmpk.7.787
https://doi.org/10.2133/dmpk.7.787
Autor:
Takashi Matsumoto, Seiji Shibahara, Izumi Komiya, Katsumi Kawaharajo, Aiko Miyata, Atsushi Tamura, Katsuyoshi Iwamatsu, Tetsuro Hara, Shigeharu Inouye, Yoshinori Orikasa
Publikováno v:
Journal of Antimicrobial Chemotherapy. 27:41-53
The antibacterial activity of a novel cephalosporin derivative, CP6162, possessing a dihydroxypyridone moiety at the C-3 side chain, was evaluated in vitro and in vivo, with ceftazidime, aztreonam and cefoperazone as the reference antibiotics. CP6162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597fec61e1ffdb417894e74131b71b74
https://doi.org/10.1093/jac/27.1.41
https://doi.org/10.1093/jac/27.1.41
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:909-918
The renal excretion mechanism of ME1206, an active form of a novel oral cephalosporin antibiotic ME1207, was studied in rats using the renal clearance method and in rabbits and dogs applying the stop-flow analysis method. Excretion ratio (ER) was 3.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2efb5e55cd471402dda0d7e08d592277
https://doi.org/10.2133/dmpk.6.909
https://doi.org/10.2133/dmpk.6.909
Autor:
Masahiro Nomoto, Hisashi Suzuki, Jun Morita, Kazumasa Aizawa, Tohru Kurosawa, Tomoko Tatebayashi, Izumi Komiya
Publikováno v:
Journal of pharmaceutical sciences. 98(4)
There are only a few reports on the methods that predict in vivo bioavailability from in vitro intestinal parameters. In the present study, we constructed physiological models where we examined if in vivo rat bioavailability was predictable from in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe148c7dd6a4c8ed35a2975a349cb0d
https://pubmed.ncbi.nlm.nih.gov/18683862
https://pubmed.ncbi.nlm.nih.gov/18683862