Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Izumi Hide"'
Autor:
Izumi Hide, Hiroko Shiraki, Akihiro Masuda, Takuya Maeda, Mayuka Kumagai, Nao Kunishige, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 1, Pp 55-67 (2023)
Microglial removal of dying cells plays a beneficial role in maintaining homeostasis in the CNS, whereas under some pathological conditions, inflammatory microglia can cause excessive clearance, leading to neuronal death. However, the mechanisms unde
Externí odkaz:
https://doaj.org/article/2d9172ff569342c5b292d2925a9652a7
Autor:
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent prote
Externí odkaz:
https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09
Autor:
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 307-314 (2022)
G protein-coupled receptor 3 (GPR3) constitutively activates Gαs proteins without any ligands and is predominantly expressed in neurons. Since the expression and physiological role of GPR3 in immune cells is still unknown, we examined the possible r
Externí odkaz:
https://doaj.org/article/404c9a5e05b5429a86af4e272363a08c
Autor:
Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 187-195 (2022)
Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells t
Externí odkaz:
https://doaj.org/article/9330ce51e2554433b6a7217e7813e997
Autor:
Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105811- (2022)
Glaucoma is an optic neuropathy and is currently one of the most common diseases that leads to irreversible blindness. The axonal degeneration that occurs before retinal ganglion neuronal loss is suggested to be involved in the pathogenesis of glauco
Externí odkaz:
https://doaj.org/article/cbcc8843261b4ff890e0fed40f1d323c
Autor:
Serika Motoike, Kei Taguchi, Kana Harada, Masaya Asano, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 4, Pp 297-307 (2021)
Herein, we investigated the functional association of the serotonin transporter (SERT) with syntaxin-3 (STX3). We first overexpressed SERT and STX3 in various cells and examined their interaction, localization, and functional association. Immunopreci
Externí odkaz:
https://doaj.org/article/a7c2315476ef45a8af9f1ada51c7284f
Autor:
Masaya Asano, Serika Motoike, Chika Yokota, Naoto Usuki, Hikaru Yamamoto, Tomoaki Urabe, Kazusa Katarao, Izumi Hide, Shigeru Tanaka, Masashi Kawamoto, Masahiro Irifune, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 1, Pp 29-36 (2019)
The serotonin transporter (SERT) is functionally regulated via membrane trafficking. Our previous studies have demonstrated that the SERT C-terminal deletion mutant (SERTΔCT) showed a robust decrease in its membrane trafficking and was retained in t
Externí odkaz:
https://doaj.org/article/d73623f3346246769ae8dadbf2c820a5
Autor:
Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242349 (2020)
The pathway from the medial habenular nucleus to the interpeduncular nucleus, in which nicotinic acetylcholine receptor (nAChR) including the α3 and α5 subunits (α3 * and α5 * nAChRs) are expressed, is implicated in nicotine dependence. We invest
Externí odkaz:
https://doaj.org/article/0494c2af5e2c4eec969d98a15d14dab9
Autor:
Takeshi Miyahara, Naoko Adachi, Takahiro Seki, Izumi Hide, Shigeru Tanaka, Naoaki Saito, Masahiro Irifune, Norio Sakai
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 20-29 (2018)
Propofol is the most commonly used anesthetic. Immunohistochemical studies have reported that propofol translocated protein kinase Cs (PKCs) in cardiomyocyte in a subtype-specific manner; however detailed features of the propofol-induced translocatio
Externí odkaz:
https://doaj.org/article/ec404e1d2af64916b6335269c03bae0d
Autor:
Gintare Zemgulyte, Shigeru Tanaka, Izumi Hide, Norio Sakai, Katryna Pampuscenko, Vilmante Borutaite, Daiva Rastenyte
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 312 (2021)
Stroke is the second leading cause of death worldwide. Treatment options for ischemic stroke are limited, and the development of new therapeutic agents or combined therapies is imperative. Growing evidence suggests that metformin treatment, due to it
Externí odkaz:
https://doaj.org/article/24b066560a21425293be75f3b7ddcec6