Zobrazeno 1 - 10 of 65 pro vyhledávání: '"Izumi, Sasaki"'
1
Akademický článek
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
Autor: Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz: https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
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2
Akademický článek
SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells
Autor: Shu Horiuchi, Takuya Koike, Hirofumi Takebuchi, Katsuaki Hoshino, Izumi Sasaki, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Daisuke Kitamura
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Generation of memory B cells is one of the key features of adaptive immunity as they respond rapidly to re-exposure to the antigen and generate functional antibodies. Although the functions of memory B cells are becoming clearer, the regulation of me
Externí odkaz: https://doaj.org/article/b6035da134f149289bcc8ae857600063
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3
Akademický článek
Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency
Autor: Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, Norio Kawamoto, Saori Kadowaki, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Miyuki Tsumura, Yusuke Yamashita, Shinobu Tamura, Takashi Orimo, Toshiya Ozasa, Takashi Kato, Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Yutaka Inaba, Kayo Kunimoto, Satoshi Okada, Takeshi Taketani, Koichi Nakanishi, Shigeo Murata, Koh-ichiro Yoshiura, Tsuneyasu Kaisho
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genetic variants of proteasome subunit genes have been shown to associate with perturbed immune function. Here authors show that a heterozygous missense variant of the immunoproteasome subunit β-type 9 causes an autoinflammatory/immune deficiency sy
Externí odkaz: https://doaj.org/article/bc153bd94dab48289d8e89f5cfa52002
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4
Akademický článek
Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis
Autor: Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions. One DC subset, conventional type 1 DC (cDC1), can be defined by expression of CD8α/CD103 in
Externí odkaz: https://doaj.org/article/20ea9d4a9ec94694a339a3d4eab24e4f
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5
Akademický článek
Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors
Autor: Hidetoshi Tozaki-Saitoh, Izumi Sasaki, Tomohiro Yamashita, Masako Hosoi, Takahiro A. Kato, Makoto Tsuda
Publikováno v: Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 133-140 (2020)
Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via β-adrenergic receptors (β-ARs). Microglia, resident macrophages in the CNS, have a cent
Externí odkaz: https://doaj.org/article/7ebaace02f3548beb4752bcbe7ed8597
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6
Augmentation of Stimulator of Interferon Genes–Induced Type I Interferon Production in COPA Syndrome
Autor: Takashi Orimo, Junko Takita, Hidenori Nakamura, Masaki Yamamoto, Kyoichi Isono, Toshiaki Miyamoto, Takashi Kato, Kohei Murakami, Tsuneyasu Kaisho, Tadashi Matsubayashi, Yuri Fukuda-Ohta, Hiroaki Hemmi, Yoshiro Otsuki, Yoshitaka Honda, Saki Takayama, Kazushi Izawa, Izumi Sasaki, Takahiro Yasumi, Ryuta Nishikomori
Publikováno v: Arthritis & Rheumatology. 73:2105-2115
OBJECTIVE Coatomer subunit alpha (COPA) syndrome, also known as autoinflammatory interstitial lung, joint, and kidney disease, is caused by heterozygous mutations in COPA. We identified a novel COPA variant in 4 patients in one family. We undertook t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa245791a6aecaefb09e199c65ded2f1
https://doi.org/10.1002/art.41790
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8
Preparation and Inflammasome Activation of Murine Bone Marrow-Derived and Resident Peritoneal Macrophages
Autor: Izumi, Sasaki, Tsuneyasu, Kaisho
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2427
Cholera toxin (CT), secreted by Vibrio cholerae, not only causes cholera but also functions as an immune adjuvant. Macrophages, which respond to a variety of immune adjuvants, are quite heterogenous and their development and function depend on the ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::215b82a9db9ea1959e49c43daafae317
https://pubmed.ncbi.nlm.nih.gov/35619028
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9
Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors
Autor: Takahiro A. Kato, Hidetoshi Tozaki-Saitoh, Masako Hosoi, Makoto Tsuda, Tomohiro Yamashita, Izumi Sasaki
Publikováno v: Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 133-140 (2020)
Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via β-adrenergic receptors (β-ARs). Microglia, resident macrophages in the CNS, have a cent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ce9e44fcb82d73be03cfa5865a6bc2
http://www.sciencedirect.com/science/article/pii/S1347861320300311
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