Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Izrael-Tomasevic A"'
Akademický článek
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Akademický článek
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Autor:
Jung-Kuei Chen, Karl A. Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng, Erika D. Handly, Jesse C. Patterson, Ian G. Cannell, Lucia Suarez-Lopez, Aaron M. Hosios, Anh Dinh, Donald S. Kirkpatrick, Kebing Yu, Christopher M. Rose, Jonathan M. Hernandez, Haeun Hwangbo, Adam C. Palmer, Matthew G. Vander Heiden, Ömer H. Yilmaz, Michael B. Yaffe
Publikováno v:
bioRxiv
5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP depletion and activation of the DNA damage response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadd78608f21d007548dbd022c63b683
https://doi.org/10.1101/2023.04.28.538590
https://doi.org/10.1101/2023.04.28.538590
Autor:
Wayne J. Fairbrother, Sayumi Yamazoe, Ingrid E. Wertz, Nicole Blaquiere, Steven T. Staben, Willem den Besten, Domagoj Vucic, Kebing Yu, Melinda M. Mulvihill, Elizabeth Helgason, Erin C. Dueber, Kshitij Verma, Wilson Phung, Tatiana Goncharov, Sumit Prakash, Anita Izrael-Tomasevic
Publikováno v:
Journal of the American Chemical Society. 143:10571-10575
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small molecules could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small molecules was modified to append a nucleophilic primary amine.
Akademický článek
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Autor:
Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz:
https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
Autor:
Wyne P. Lee, Donald S. Kirkpatrick, Matthias Kist, Joshua D. Webster, Domagoj Vucic, Kim Newton, Eugene Varfolomeev, Xiumin Wu, M. Cristina de Almagro, Kebing Yu, Jeremy Murray, Stefanie Duttler, Tatiana Goncharov, Anita Izrael-Tomasevic
Publikováno v:
Cell Death and Differentiation
Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and prevention of disease. A caspase-independent regulated form of cell death called necroptosis is rapidly emerging as an important mediator of a number of human
Autor:
Vishva M. Dixit, Yan Qu, Shahram Misaghi, David Arnott, Kim Newton, Anita Izrael-Tomasevic, Allie Maltzman
Publikováno v:
The Journal of Experimental Medicine
By engineering a mutant mouse strain that preserves the scaffolding function of NLRC4, Dixit et al. show cooperativity between it and another NOD family sensor, NLRP3.
NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular prote
NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular prote
Autor:
Patrick Trojer, Tobias M. Maile, Jun Liang, Marie Classon, Gulfem D. Guler, Tommy K. Cheung, Charles Tindell, David Arnott, Alexandre Masselot, Feng Zhao, Anita Izrael-Tomasevic
Publikováno v:
Molecular & Cellular Proteomics : MCP
Mass spectrometry is a powerful alternative to antibody-based methods for the analysis of histone post-translational modifications (marks). A key development in this approach was the deliberate propionylation of histones to improve sequence coverage
Autor:
Daisy Bustos, Lisa D. Belmont, Eugene Varfolomeev, Kebing Yu, Tatiana Goncharov, Donald S. Kirkpatrick, Alexandre Masselot, Anita Izrael-Tomasevic, Corey E. Bakalarski, Domagoj Vucic
Publikováno v:
Biochemical Journal. 466:45-54
Evasion of cell death is one crucial capability acquired by tumour cells to ward-off anti-tumour therapies and represents a fundamental challenge to sustaining clinical efficacy for currently available agents. Inhibitor of apoptosis (IAP) proteins us