Best practices and recommendations for drug regimens and plasma exchange for immune thrombotic thrombocytopenic purpura

Autor: Gomez-Segui, I, Izquierdo, CP, Comos, JD

Publikováno v: Expert Review Of Hematology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Introduction Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. TTP pathophysiology is based on a severe ADAMTS13 deficien

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https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14484

Should we consider caplacizumab as routine treatment for acute thrombotic thrombocytopenic purpura? An expert perspective on the pros and cons.

Autor: Seguí IG; Hematology Department institution, H. Universitario y Politécnico La Fe, Valencia, Valencia, Spain., Mingot Castellano ME; Hospital Universitario Virgen del Rocío, Hematology Department, Sevilla, Spain., Izquierdo CP; Hematology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain., de la Rubia J; Hematology Department institution, H. Universitario y Politécnico La Fe, Valencia, Valencia, Spain.; Internal Medicine, Universidad Católica 'San Vicente Mártir', Valencia, Spain.

Publikováno v: Expert review of hematology [Expert Rev Hematol] 2024 Jan-Mar; Vol. 17 (1-3), pp. 9-25. Date of Electronic Publication: 2024 Feb 20.

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura.

Autor: Izquierdo CP; Department of Hematology, Hospital General Universitario Gregorio Marañón (HGUGM) Madrid, Instituto de Investigación Gregorio Marañón, Madrid, Spain., Mingot-Castellano ME; Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Seville, Spain., Fuentes AEK; Department of Hematology and Hemotherapy, Hospital La Paz, Madrid, Spain., García-Arroba Peinado J; Banc de Sang i Teixits, Hospital Universitario Joan XXIII, Tarragona, Spain., Cid J; Apheresis and Cellular Therapy Unit, Department of Hemotherapy & Hemostasis, ICMHO, IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Jimenez MM; Department of Hematology, University Hospital Vall d'Hebron, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona, Spain., Valcarcel D; Department of Hematology, University Hospital Vall d'Hebron, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona, Spain., Gómez-Seguí I; Department of Hematology, Hospital La Fe, Valencia, Spain., de la Rubia J; Department of Hematology, Hospital La Fe, Valencia, Spain., Martin P; Therapeutic Apheresis Unit, Hematology Department, Hospital Clínico San Carlos, Madrid, Spain., Goterris R; Hematology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain., Hernández L; Hospital General Universitario de Alicante, Alicante, Spain., Tallón I; Hospital Virgen Macarena, Sevilla, Spain., Varea S; Hospital San Chinarro, Madrid, Spain., Fernández M; Hospital Universitario de A Coruña, A Coruña, Spain., García-Muñoz N; Hospital de Bellvitge, Barcelona, Spain., Vara M; Hematology Department, Hospital Universitario de Cruces, Baracaldo, Spain., Zarzoso MF; Hospital Universitario Dr. Peset, Valencia, Spain., García-Candel F; Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Paciello ML; Hospital Universitario 12 de Octubre, Madrid, Spain., García-García I; Hospital Universitario 12 de Octubre, Madrid, Spain., Zalba S; Hospital Universitario de Navarra, Pamplona, Spain., Campuzano V; Hospital Universitario Burgos, Burgos, Spain., Gala JM; Hospital Universitario Central de Asturias, Asturias, Spain., Estévez JV; Apheresis & Transfusion Unit, Department of Hematology & Hemotherapy, CAULE, Complejo Asistencial Universitario de León, León, Spain., Jiménez GM; Department of Hematology, Hospital Universitario Ramon y Cajal, Madrid, Spain., López Lorenzo JL; Department of Hematology Hospital Universitario Fundación Jiménez Díaz, Hematologia Madrid, Spain., Arias EG; Hospital Universitario de Villalba, Madrid, Spain., Freiría C; Hospital Universitario de Castellon, Castelló, Spain., Solé M; Hospital Universitario Juan Ramón Jiménez, Huelva, Spain., Ávila Idrovo LF; Hospital Universitario de Canarias, Tenerife, Spain., Hernández Castellet JC; Hospital Puerta del Mar, Cádiz, Spain., Cruz N; Hospital Universitario Dr. Negrín, Las Palmas, Spain., Lavilla E; Hospital Universitario Lucus Augusti, Lugo, Spain., Pérez-Montaña A; Hospital Universitario Son Espases, Palma de Mallorca, Spain., Atucha JA; Hospital de Basurto, Bilbao, Spain., Moreno Beltrán ME; Hospital Costa del Sol, Marbella, Málaga, Spain., Moreno Macías JR; Hospital Universitario de Albacete, Albacete, Spain., Salinas R; Hospital del Sagrat Cor, Universitat Internacional de Catalunya; Banc de Sang i Teixits de Catalunya, Barcelona, Spain., Del Rio-Garma J; Department of Hematology, University Hospital of Ourense, Ourense, Spain.

Publikováno v: Blood advances [Blood Adv] 2022 Dec 27; Vol. 6 (24), pp. 6219-6227.