Výsledky vyhledávání - "Izolda Segal"

Akademický článek

Synthesis and Neurotropic Activity of Novel Quinoline Derivatives

Autor: Skaidrite Germane, Alla Zablotskaya, Izolda Segal, Edmunds Lukevics

Publikováno v: Molecules, Vol 2, Iss 12, Pp 180-185 (1997)

Hydroxyalkyl and carboxyalkyl derivatives of silatetrahydroisoquinoline, tetrahydroisoquinoline and tetrahydroquinoline have been synthesized. Their neurotropic activity has been investigated.

Externí odkaz: https://doaj.org/article/eb5fb2ff4b2842eeb2167d73359c7400

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Silyl Modification of Biologically Active Compounds. 14. Organosilicon Lipid-like Derivatives of Hydroxyethyl Tetrahydro(iso)quinoline and Thiazole with Antitumour, Antibacterial and Antifungal Properties

Autor: Yuris Popelis, Izolda Segal, Vizma Nikolajeva, Galina Kazachonokh, Irina Shestakova, Alla Zablotskaya

Publikováno v: Silicon. 10:1129-1138

A series of novel lipid-like O- and N-(3-trimethylsilyl)propyl derivatives of N-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline, -tetrahydroisoquinoline and 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole have been obtained in order to facilitate penetration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d66ef369a19ae023751cff59d60bc9a8
https://doi.org/10.1007/s12633-017-9585-2

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N-Heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action

Autor: Irina Shestakova, Vizma Nikolajeva, Galina Makarenkova, Athina Geronikaki, Izolda Segal, Alla Zablotskaya

Publikováno v: Pharmacological Reports. 69:575-581

Pharmacological effects of biologically active “small molecules” can be improved by their targeted modification, which affects drug delivery and interaction with tumor cells and microorganisms. We aimed to evaluate anticancer and antimicrobial ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2982333dfa34177f2d36abaad071c01b
https://doi.org/10.1016/j.pharep.2017.01.028

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Iron oxide/oleic acid magnetic nanoparticles possessing biologically active choline derivatives

Autor: Dmitry Zablotsky, Mikhail Maiorov, Alla Zablotskaya, Elmars Blums, Izolda Segal

In recent years, synthetic magnetic nanoparticles have made a major contribution to biomedicine. Interest in iron oxide magnetic nanoparticles conditioned by the fact that they are nontoxic, and possess the unique opportunity to deliver medicines to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2178d327a8da63a2b58fab936eee678c
https://doi.org/10.1016/b978-0-12-813661-4.00007-9

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Iron oxide superparamagnetic nanocarriers bearing amphiphilic N-heterocyclic choline analogues as potential antimicrobial agents

Autor: Alla Zablotskaya, Dmitry Zablotsky, Yuris Popelis, Vizma Nikolajeva, Izolda Segal, Mikhail Maiorov, Anatoly Mishnev, Elmars Blums, Daina Eze

Publikováno v: Applied Organometallic Chemistry. 29:376-383

Magnetic nanoparticles represent an advanced tool in biomedicine because they can be simultaneously functionalized and guided using a magnetic field. Iron oxide magnetic nanoparticles precoated with oleic acid and bearing novel antimicrobial N-hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3897950df3d31e120eaf340cc5c448ad
https://doi.org/10.1002/aoc.3302

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Synthesis and biological evaluation of lipid-like 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole derivatives as potential anticancer and antimicrobial agents

Autor: Galina Kazachonokh, Yuris Popelis, Izolda Segal, Athina Geronikaki, Daina Eze, Alla Zablotskaya, Irina Shestakova, Vizma Nikolajeva

Publikováno v: MedChemComm. 6:1464-1470

A series of new lipid-like thiazole derivatives have been synthesized in good yields by O-alkylation of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole, a thiamine metabolite, under phase transfer catalysis conditions followed by N-alkylation with the aim t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dda4a36da1360faaa8f5a0ad95892838
https://doi.org/10.1039/c5md00140d

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Superparamagnetic iron oxide/oleic acid nanoparticles with immobilized organosilicon derivatives ofN-(2-hydroxyethyl)tetrahydroisoquinoline: synthesis, morphology and interaction with normal and tumour cells

Autor: Elmars Blums, Irina Shestakova, Alla Zablotskaya, Ilona Domracheva, Mikhail Maiorov, Izolda Segal, Anatoly Mishnev

Publikováno v: Applied Organometallic Chemistry. 27:716-722

Superparamagnetic iron oxide/oleic acid nanoparticles bearing lipid-like organosilicon N-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline derivatives have been synthesized with the aim of their potential biomedical application. X-ray diffraction analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e36ee82473bc83624e9d370b2edba5b
https://doi.org/10.1002/aoc.3049

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Silyl modification of biologically active compounds. 13. Synthesis, cytotoxicity and antibacterial action ofN-methyl-N-(2-triorganylsiloxyethyl)-1,2,3,4-tetrahydro(iso)quinolinium iodides

Autor: Solveiga Grinberga, Yuris Popelis, Vizma Nikolajeva, Daina Eze, Irina Shestakova, Alla Zablotskaya, Izolda Segal

Publikováno v: Applied Organometallic Chemistry. 27:114-124

A series of N-methyl-N-(2-triorganylsiloxyethyl)-1,2,3,4-tetrahydro(iso)quinolinium iodides has been synthesized via dehydrocondensation reaction of N-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline, N-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1deaa66d71805189a45abe69cd0ab128
https://doi.org/10.1002/aoc.2952

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