Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Izolda Mileva"'
1
Akademický článek
Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis
Autor: Amy Yu, Carson Cable, Sachin Sharma, Mahbubul H. Shihan, Aras N. Mattis, Izolda Mileva, Yusuf A. Hannun, Caroline C. Duwaerts, Jennifer Y. Chen
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver. Non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a leading cause of liver transpl
Externí odkaz: https://doaj.org/article/6725eb13e1904aa59cea259f043342fe
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2
Akademický článek
1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
Autor: Jean-Philip Truman, Christian F. Ruiz, Emily Montal, Monica Garcia-Barros, Izolda Mileva, Ashley J. Snider, Yusuf A. Hannun, Lina M. Obeid, Cungui Mao
Publikováno v: Journal of Lipid Research, Vol 63, Iss 1, Pp 100154- (2022)
Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosine kinase 1 (SK1) in ca
Externí odkaz: https://doaj.org/article/e13c757acba64c0c8e8bee3ea201beb3
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3
Akademický článek
Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5 [S]
Autor: Benjamin Newcomb, Cosima Rhein, Izolda Mileva, Rasheed Ahmad, Christopher J. Clarke, Justin Snider, Lina M. Obeid, Yusuf A. Hannun
Publikováno v: Journal of Lipid Research, Vol 59, Iss 7, Pp 1219-1229 (2018)
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was n
Externí odkaz: https://doaj.org/article/d929eab6ae61435eaff45ec3e1c7b339
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5
Targeting Acid Ceramidase Ameliorates Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis
Autor: Amy Yu, Carson Cable, Mahbubul H. Shihan, Sachin Sharma, Aras N. Mattis, Izolda Mileva, Yusuf A. Hannun, Caroline C. Duwaerts, Jennifer Y. Chen
1)ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver. Nonalcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a leading cause of liver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdbfd5d708aacd6cfd766da13ee04d1f
https://doi.org/10.1101/2022.07.10.499388
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6
1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
Autor: Ashley J. Snider, Emily Montal, Jean-Philip Truman, Cungui Mao, Christian F. Ruiz, Izolda Mileva, Yusuf A. Hannun, Lina M. Obeid, Monica Garcia-Barros
Publikováno v: Journal of Lipid Research, Vol 63, Iss 1, Pp 100154-(2022)
Cancer cells can become dependent on exogenous serine, depletion of which results in slower growth and activation of a number of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b040782b7e8a4c792510939b717e50a
http://www.sciencedirect.com/science/article/pii/S0022227521001371
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8
Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates
Autor: Chih-Li Lin, Cungui Mao, Ruijuan Xu, Mónica García-Barros, Ashley Snider, Catherine K. Luo, Yusuf A. Hannun, Izolda Mileva, Lina M. Obeid, Michael V. Wiles, Benjamin E. Low, Ming-Song Li, Jennifer Schrandt, Fang Li, Xian-Cheng Jiang
Publikováno v: The FASEB Journal. 32:3058-3069
Sphingosine-1-phosphate (S1P) plays important roles in cardiovascular development and immunity. S1P is abundant in plasma because erythrocytes-the major source of S1P-lack any S1P-degrading activity; however, much remains unclear about the source of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccedaed6c0c7b8b262ea69a2acb55c6
https://doi.org/10.1096/fj.201700445rr
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9
Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5 [S]
Autor: Cosima Rhein, Benjamin Newcomb, Christopher J. Clarke, Lina M. Obeid, Justin Snider, Izolda Mileva, Rasheed Ahmad, Yusuf A. Hannun
Publikováno v: Journal of Lipid Research, Vol 59, Iss 7, Pp 1219-1229 (2018)
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97658cb54370662b8b98246b53e3b35
http://www.sciencedirect.com/science/article/pii/S0022227520330790
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10
DEGS1 variant causes neurological disorder
Autor: Raed Khoury, Yael Barhum, Rachel Straussberg, Yuval Yogev, Ohad S. Birk, Ruijuan Xu, Alex Zvulunov, Izolda Mileva, Cungui Mao, Vadim Dolgin, Osnat Konen
Publikováno v: Eur J Hum Genet
Sphingolipidoses are monogenic lipid storage diseases caused by variants in enzymes of lipid synthesis and metabolism. We describe an autosomal recessive complex neurological disorder affecting consanguineous kindred. All four affected individuals, b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bc6b3e779719d2ecd2be73301e013
https://pubmed.ncbi.nlm.nih.gov/31186544
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