Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Izolda A. Popova"'
Autor:
Lei A. Qin, Josette M. Kamel, Izolda A. Popova, Kirsten L. Viola, Kevin Luo, Anthea Weng, Milena A. Barcelos, Adrian M. Bebenek, William L. Klein, Erika N. Cline, Adriano Sebollela, Vanessa N. Bezerra, Pauline T. Velasco, Natalia M. Lyra e Silva, Nadia DiNunno, Jay Ahn, Pascale N. Lacor, Xiao-xia Sun, Jason Patel, Sergio T. Ferreira, Nathalia R. Pinheiro
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have been identified, both in vitro and in vivo, ranging
Autor:
Amanda L. Eckermann, Pauline T. Velasco, William L. Klein, Adriano Sebollela, Kevin B. Lee, Marie C. Heffern, Kirsten L. Viola, Izolda A. Popova, Benjamin N. Tiano, Pascale N. Lacor, Xiao-xia Sun, Thomas J. Meade
Publikováno v:
ACS chemical neuroscience. 3(11)
Amyloid β42 self-assembly is complex, with multiple pathways leading to large insoluble fibrils or soluble oligomers. Oligomers are now regarded as most germane to Alzheimer's pathogenesis. We have investigated the hypothesis that oligomer formation