Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Izidor, Sosič"'
Autor:
Barbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2995-3018 (2024)
The 4,6-substituted-1,3,5-triazin-2(1H)-ones are promising inhibitors of human DNA topoisomerase IIα. To further develop this chemical class targeting the enzyme´s ATP binding site, the triazin-2(1H)-one substitution position 6 was optimized. Inspi
Externí odkaz:
https://doaj.org/article/a2d96ff88e0843fbb8c7a452b3c05308
Autor:
Nika Strašek Benedik, Ana Dolšak, Urban Švajger, Izidor Sosič, Stanislav Gobec, Matej Sova
Publikováno v:
ACS Omega, Vol 9, Iss 2, Pp 2362-2382 (2024)
Externí odkaz:
https://doaj.org/article/ef98ac5266814f379741038d4cb19056
Publikováno v:
ACS Omega, Vol 5, Iss 29, Pp 17868-17875 (2020)
Externí odkaz:
https://doaj.org/article/a221bc7f17a54d188f3461c05f73613b
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery. These bifunctional molecules consist of a target binding unit, a linker
Externí odkaz:
https://doaj.org/article/577af2122de04df29cfd88f10aa42f32
Autor:
Katja Pirc, Vesna Hodnik, Tina Snoj, Tea Lenarčič, Simon Caserman, Marjetka Podobnik, Hannah Böhm, Isabell Albert, Anita Kotar, Janez Plavec, Jure Borišek, Martina Damuzzo, Alessandra Magistrato, Boris Brus, Izidor Sosič, Stanislav Gobec, Thorsten Nürnberger, Gregor Anderluh
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009477 (2021)
The lack of efficient methods to control the major diseases of crops most important to agriculture leads to huge economic losses and seriously threatens global food security. Many of the most important microbial plant pathogens, including bacteria, f
Externí odkaz:
https://doaj.org/article/50b2e9458a9143078d5136235d749c19
Autor:
Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Péter Ábrányi-Balogh, Dorottya Csányi, György G. Ferenczy, Stanislav Gobec, Izidor Sosič, György M. Keserű
Publikováno v:
Cells, Vol 10, Iss 12, p 3431 (2021)
Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, inclu
Externí odkaz:
https://doaj.org/article/ad5fe72dbb704a139bb1f472787654f3
Autor:
Tihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 789 (2021)
DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to u
Externí odkaz:
https://doaj.org/article/ee00a302a11a4640be8c346b13958e36
Autor:
Ales Obreza, Katarina Grabrijan, Selmir Kadić, Fernando Juan de Lera Garrido, Izidor Sosič, Stanislav Gobec, Marko Jukič
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 4, Pp 771-781 (2017)
Using rescaffolding approach, we designed piperidine compounds decorated with an electrophilic oxathiazol-2-one moiety that is known to confer selectivity towards threonine proteases. Our efforts to prepare products according to the published procedu
Externí odkaz:
https://doaj.org/article/8d35d2c7795842f1ad7bb5a288d7f70e
Autor:
Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič
Publikováno v:
Journal of medicinal chemistry, vol. 66, no. 7, pp. 4703-4733, 2023.
Journal of medicinal chemistry, str. 4703-4733 : Ilustr., Vol. 66, iss. 7, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, str. 4703-4733 : Ilustr., Vol. 66, iss. 7, 2023
COBISS-ID: 512806681
Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e25f1087502a057345c9d203428b453
https://hdl.handle.net/20.500.12556/RUL-145892
https://hdl.handle.net/20.500.12556/RUL-145892
Autor:
Christian Steinebach, Izidor Sosič, Aleša Bricelj, Arunima Murgai, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Annika Schmidt, Patricia Lemnitzer, Finn K. Hansen, Michael Gütschow, Jan Krönke, Marcus D. Hartmann
Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and lenalidomide represent the most typical cereblon (CRBN) recruiters that are frequently utilized in proteolysis-targeting chimera (PROTAC) design. These CRBN binders, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5007a3d3f5242a9a785fa538e7c06c1e
https://doi.org/10.26434/chemrxiv-2023-zshqp
https://doi.org/10.26434/chemrxiv-2023-zshqp