Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Izhar Burhan"'
Autor:
Adeola Grace Atobatele, Elisa Tonoli, Jayakumar Vadakekolathu, Maria Pia Savoca, Melissa Barr, Yukti Kataria, Marta Rossanese, Izhar Burhan, Stephanie McArdle, Daniela Caccamo, Elisabetta A. M. Verderio
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-13 (2023)
Abstract Androgen independency is associated with poor prostate cancer (PCa) survival. Here we report that silencing of transglutaminase-2 (TG2) expression by CRISPR-Cas9 is associated with upregulation of androgen receptor (AR) transcription in PCa
Externí odkaz:
https://doaj.org/article/13a9f2f11db04ec99babc1d5d0b686a3
Autor:
Adeola Atobatele, Elisa Tonoli, Jayakumar Vadakekolathu, Maria Pia Savoca, Melissa Barr, Yukti Kataria, Marta Rossanese, Izhar Burhan, Stephanie McArdle, Daniela Caccamo, Elisabetta Verderio
Androgen independency is associated with poor prostate cancer (PCa) survival. Here we report that silencing of transglutaminase-2 (TG2) expression by CRISPR-Cas9 is associated with upregulation of androgen receptor (AR) transcription in prostate canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d59a6a6d8f4e6f36ead4cec5f2549ff
https://doi.org/10.21203/rs.3.rs-2223106/v1
https://doi.org/10.21203/rs.3.rs-2223106/v1
Autor:
Elisabetta A.M. Verderio, Timothy S. Johnson, Linghong Huang, Maria Pia Savoca, Izhar Burhan, Giulia Furini, Adeola G. Atobatele
The extracellular matrix crosslinking enzyme transglutaminase 2 (TG2) is highly implicated in tissue fibrosis that precedes end-stage kidney failure. TG2 is unconventionally secreted through extracellular vesicles in a way that depends on the heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5756a308dd74d3c995969d80a8aaaa
https://irep.ntu.ac.uk/id/eprint/39511/1/1312273_Verderio.pdf
https://irep.ntu.ac.uk/id/eprint/39511/1/1312273_Verderio.pdf
Autor:
Hugues Lortat-Jacob, Philip F. Watson, Giulia Furini, Faith Nutter, John M. Atkinson, Adeola G. Atobatele, M. Maamra, Nina Schroeder, Manlio Vinciguerra, Alessandra Scarpellini, Elisabetta A.M. Verderio, Timothy S. Johnson, Izhar Burhan
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6, pp.31343. ⟨10.1038/srep31343⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.31343. ⟨10.1038/srep31343⟩
Scientific Reports, 2016, 6, pp.31343. ⟨10.1038/srep31343⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.31343. ⟨10.1038/srep31343⟩
Transglutaminase-2 (TG2) is a new anti-fibrotic target for chronic kidney disease, for its role in altering the extracellular homeostatic balance leading to excessive build-up of matrix in kidney. However, there is no confirmation that TG2 is the onl
Autor:
Anne Imberty, Romain R. Vivès, Hugues Lortat-Jacob, Alessandra Scarpellini, Izhar Burhan, Aldo Gutierrez, Elisabetta A.M. Verderio, Timothy S. Johnson, Aline Thomas
Publikováno v:
The Journal of Biological Chemistry
Background: Extracellular transglutaminase-2 binds heparan sulfate and has adhesive/signaling pro-fibrotic functions. Results: Two clusters of basic residues, distal in the linear sequence of transglutaminase-2, are required for heparin binding and c
Publikováno v:
Transglutaminases ISBN: 9784431558231
Kidney fibrosis is regarded as a chronic wound response and tissue remodeling process consequent to a persistent tissue damage. The fibrosis is characterized by excessive extracellular matrix accumulation, fibroblast proliferation and chronic inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a3087e58b377f867a419b4656cd3474
https://doi.org/10.1007/978-4-431-55825-5_11
https://doi.org/10.1007/978-4-431-55825-5_11
Autor:
Linghong Huang, Nina Schroeder, Alessandra Scarpellini, Muriel Funck, Izhar Burhan, Elisabetta A.M. Verderio, Timothy S. Johnson
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb4540d033474699d5f6dcfa7664feb
https://europepmc.org/articles/PMC4005302/
https://europepmc.org/articles/PMC4005302/