Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Izaskun Mallona"'
Autor:
Mark D Robinson, Peiying Cai, Martin Emons, Reto Gerber, Pierre-Luc Germain, Samuel Gunz, Siyuan Luo, Giulia Moro, Emanuel Sonder, Anthony Sonrel, Jiayi Wang, David Wissel, Izaskun Mallona
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012174 (2024)
Computational biologists are frequently engaged in collaborative data analysis with wet lab researchers. These interdisciplinary projects, as necessary as they are to the scientific endeavor, can be surprisingly challenging due to cultural difference
Externí odkaz:
https://doaj.org/article/3ef38d0c3f5942499a2dc36843d17ca8
Autor:
Anthony Sonrel, Almut Luetge, Charlotte Soneson, Izaskun Mallona, Pierre-Luc Germain, Sergey Knyazev, Jeroen Gilis, Reto Gerber, Ruth Seurinck, Dominique Paul, Emanuel Sonder, Helena L. Crowell, Imran Fanaswala, Ahmad Al-Ajami, Elyas Heidari, Stephan Schmeing, Stefan Milosavljevic, Yvan Saeys, Serghei Mangul, Mark D. Robinson
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Computational methods represent the lifeblood of modern molecular biology. Benchmarking is important for all methods, but with a focus here on computational methods, benchmarking is critical to dissect important steps of analysis pipelines,
Externí odkaz:
https://doaj.org/article/21cd2e92fd404c0081d6e6fad0fc21dd
Autor:
Berta Martín, Stella Pappa, Anna Díez-Villanueva, Izaskun Mallona, Joaquín Custodio, María José Barrero, Miguel A. Peinado, Mireia Jordà
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 765-779 (2020)
Alu repeats constitute a major fraction of human genome and for a small subset of them a role in gene regulation has been described. The number of studies focused on the functional characterization of particular Alu elements is very limited. Most Alu
Externí odkaz:
https://doaj.org/article/b9458db617a340aeb78caee30e1261f7
Autor:
Maria J. Barrero, Stella Pappa, Izaskun Mallona, Miguel A. Peinado, Joaquin Custodio, Berta Martín, Anna Díez-Villanueva, Mireia Jordà
Publikováno v:
Epigenetics
Alu repeats constitute a major fraction of human genome and for a small subset of them a role in gene regulation has been described. The number of studies focused on the functional characterization of particular Alu elements is very limited. Most Alu
Autor:
Izaskun, Mallona, Ioana Mariuca, Ilie, Ino Dominiek, Karemaker, Stefan, Butz, Massimiliano, Manzo, Amedeo, Caflisch, Tuncay, Baubec
Publikováno v:
Nucleic Acids Research
Mammalian de novo DNA methyltransferases (DNMT) are responsible for the establishment of cell-type-specific DNA methylation in healthy and diseased tissues. Through genome-wide analysis of de novo methylation activity in murine stem cells we uncover
Mammaliande novoDNA methyltransferases (DNMT) are responsible for the establishment of cell-type-specific DNA methylation in healthy and diseased tissues. Through genome-wide analysis ofde novomethylation activity in murine stem cells we uncover that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e757d7b0a5e269ce50a3997eac9fa97
https://doi.org/10.1101/2020.06.12.147991
https://doi.org/10.1101/2020.06.12.147991
Autor:
Victor Barrera, Miguel A. Peinado, Anna Díez-Villanueva, Izaskun Mallona, Tanya Vavouri, Berta Martín, Sergi Lois, Manel Esteller, Mireia Jordà
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Cancer cells exhibit multiple epigenetic changes with prominent local DNA hypermethylation and widespread hypomethylation affecting large chromosomal domains. Epigenome studies often disregard the study of repeat elements owing to technical complexit
Autor:
Miguel A. Peinado, Xiangqian Kong, Shinji Maegawa, Nicholas C. Zachos, Yong Tao, Yuba R. Bhandari, Byunghak Kang, Elana J. Fertig, Jean Pierre J. Issa, Yi Cai, Wenbing Xie, Stephen B. Baylin, Daniel A. Petkovich, Izaskun Mallona, Genevieve Stein-O’Brien, Ray Whay Chiu Yen, Yuezheng Zhang, Hariharan Easwaran, Nita Ahuja, Stephen M. Brown, Cynthia A. Zahnow, Xiaojian Shao, Jai Thakor, Himani Vaidya, Zhihao Lu, Julie In
Publikováno v:
Cancer Cell
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter hypermethylation spontaneously arises in cells mimicking the human aging-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726d795dd960279d63396d9c2016bc01
https://europepmc.org/articles/PMC6636642/
https://europepmc.org/articles/PMC6636642/
Epigenomic plasticity is interconnected with chromatin structure and gene regulation. In tumor progression, orchestrated remodeling of genome organization accompanies the acquisition of malignant properties. DNA methylation, a key epigenetic mark ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b7a46def72823311c0bdf2927506a5
https://doi.org/10.1101/428730
https://doi.org/10.1101/428730
Autor:
Raquel Buj, Didac Mauricio, Miguel A. Peinado, Carles Zafon, Jordi L. Reverter, Anna Díez-Villanueva, Mireia Roca, Manel Puig-Domingo, Mireia Jordà, Jose Luis Mate, Izaskun Mallona
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 28(5)
Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. Unlike most cancers, its incidence has dramatically increased in the last decades mainly due to increased diagnosis of indolent PTCs. Adequate risk stratification is crucial to