Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Izabela Tworowska"'
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
Somatostatin analogues have been examined as a treatment for somatostatin receptor overexpressing tumors for years; specifically, octreotate (TATE) and octreotide (TOC). Several versions of these analogues coupled to beta or gamma nuclides are curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e6a724e74a057394756c3dcd33534f
https://doi.org/10.1158/1535-7163.c.6539611
https://doi.org/10.1158/1535-7163.c.6539611
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
A biodistribution study was done in CD-1 non-tumor bearing mice to compare the male and female organ uptake of 212Pb-DOTAMTATE at 4hr and 24hr post drug injection. No significant difference is observed between the two sexes in all critical organs at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2ba2608cdf1d0ef61c8d4881d85e36
https://doi.org/10.1158/1535-7163.22510417.v1
https://doi.org/10.1158/1535-7163.22510417.v1
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
A biodistribution study in athymic nude tumor bearing mice four hours post drug injection showed similar tumor uptake in tumors between 250mm3 and 1500mm3 (Panel A). Results were similar in all other organs examined by biodistribution. Examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d2707aa8991a5ceb6bcc00de64adb6
https://doi.org/10.1158/1535-7163.22510414.v1
https://doi.org/10.1158/1535-7163.22510414.v1
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
Alpha imaging of tumors treated with 212Pb-DOTAMTATE showed homogenous distribution of the drug at all tumor sizes up to 1500mm3 (Panel B). Kidney protection agent consisting of 35mg lysine are effective at reducing kidney uptake of 212Pb-DOTAMTATE b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b90ff6a7df8d3b6a635414fb600c4a2
https://doi.org/10.1158/1535-7163.22510411.v1
https://doi.org/10.1158/1535-7163.22510411.v1
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
At 20 µCi, there were relatively mild and reversible effects on weight gain (Panel A) and leukocyte counts (Panel B). Initially, animals in the 40µCi treatment group lost body weight and presented the strongest leukopenia but began to recover by 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137faec1ae2444c029ef0dfb84eda666
https://doi.org/10.1158/1535-7163.22510408.v1
https://doi.org/10.1158/1535-7163.22510408.v1
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
There was a dose-related decrease in the mean values for WBCs (Panel A) and platelet (Panel B) numbers following each IV administration. There was partial to full recovery in mice receiving fractionated dose as compared to single dose administration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fece3f0f48a6974509419ed693c49a
https://doi.org/10.1158/1535-7163.22510405.v1
https://doi.org/10.1158/1535-7163.22510405.v1
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
A binding study of 212Pb-DOTAMTATE to AR42J, an SSTR2 expressing cell line, yielded a Kd of 12.9nM (Panel A) A dose dependent cytotoxic effect can be seen with a 50% viability observed between 12.5nCi/ml and 25nCi/ml (Panel B).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de4d97742502c44e8b2eb771e76ed8f
https://doi.org/10.1158/1535-7163.22510420
https://doi.org/10.1158/1535-7163.22510420
Autor:
Julien J. Torgue, Ebrahim S. Delpassand, Izabela Tworowska, Amal Saidi, Tania A. Rozgaja Stallons
A biodistribution study was done in CD-1 non-tumor bearing mice to compare the uptake of 212Pb-DOTAMTATE and 203Pb-DOTAMTATE at 4hr and 24hr post drug injection. No significant difference is observed between the 212Pb-DOTAMTATE and 203Pb-DOTAMTATE in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9f6f721df2ffd7dd0c465b01aaddd4
https://doi.org/10.1158/1535-7163.22510402
https://doi.org/10.1158/1535-7163.22510402
Autor:
Ebrahim S. Delpassand, David Ranganathan, Ali Abbasi, Rodolfo Nunez, Nilesh K. Wagh, Ayman M. Gaber, A. Shafie, Izabela Tworowska
Publikováno v:
Journal of the National Comprehensive Cancer Network. 18:CLO20-034
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e628930094b93feb5120fdc125b94164
https://doi.org/10.6004/jnccn.2019.7422
https://doi.org/10.6004/jnccn.2019.7422
Autor:
Ayman M. Gaber, Rodolfo Nunez, Andreas Kjaer, Afshin Shafie, David Ranganathan, Ali Abbasi, Nilesh K. Wagh, Ebrahim S. Delpassand, Izabela Tworowska
Publikováno v:
Journal of Nuclear Medicine. 61:890-896
Studies demonstrate that the investigational 64Cu-DOTATATE radiopharmaceutical may provide diagnostic and logistical benefits over available imaging agents for patients with somatostatin receptor (SSTR)–positive neuroendocrine tumors (NETs). Accord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b587d7f504b18994a9b4ea13dd1c8f94
https://doi.org/10.2967/jnumed.119.236091
https://doi.org/10.2967/jnumed.119.236091