Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Izabela Sujka-Kwok"'
Autor:
Filippo Petti, Jonathan F. Bean, Stuart Thomson, David Epstein, Melissa Monaghan, John D. Haley, Gretchen M. Argast, Peter Mercado, Sean L. Seymour, Izabela Sujka-Kwok
Publikováno v:
Clinical & Experimental Metastasis
Abtract Epithelial–mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancers. While considerable effort has focused in the regulators involved in the transition process, we have focused on
Autor:
Neil W. Gibson, David Epstein, Maryland Rosenfeld-Franklin, Mark Miglarese, Izabela Sujka-Kwok, Alexandra Eyzaguirre, Kenneth K. Iwata, Filippo Petti, Elizabeth Buck, Sharon Barr, John D. Haley, Stuart Thomson, Suzanne Russo
Publikováno v:
Clinical & Experimental Metastasis
Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin. As carcinomas progress, these tumors may lose epithelial morphology and acquire mesenchymal characteristics which contribute to metastatic potential. An epi
Publikováno v:
Clinicalexperimental metastasis. 25(8)
NSCLC cells with a mesenchymal phenotype have shown a marked reduction in sensitivity to EGFR inhibitors, though the molecular rationale has remained obscure. Here we find that in mesenchymal-like tumor cells both tyrosine phosphorylation of EGFR, Er