Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Izabela P. Klaska"'
Autor:
Izabela P. Klaska, Tian Yu, Rosie Fordyce, Koju Kamoi, Richard J. Cornall, Cristina Martin-Granados, Lucia Kuffova, John V. Forrester
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease. Sessile dendritic cells (DC) are considered the main instru
Externí odkaz:
https://doaj.org/article/15a83eb5a4514cd0bdbba1118b7e9ad2
Autor:
Yi-Hsia Liu, Christine Mölzer, Kimmo Makinen, Koju Kamoi, Clare L. C. Corbett, Izabela P. Klaska, Delyth M. Reid, Heather M. Wilson, Lucia Kuffová, Richard J. Cornall, John V. Forrester
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU) model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the promoter for interphotoreceptor retinol binding protein (IRBP). We pr
Externí odkaz:
https://doaj.org/article/3369c1a46cdd4c748e1c067e9394d08e
Autor:
Christine Mölzer, Yi-Hsia Liu, Elizabeth Muckersie, Izabela P. Klaska, Richard Cornall, Heather M. Wilson, Lucia Kuffová, John V. Forrester
Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening, presumed autoimmune disease, accountable for ~ 10% of all blindness in the developed world. We have investigated the association of uveitis with inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::692f08f2de286f401d5c510d42ba6192
https://doi.org/10.21203/rs.3.rs-1776256/v1
https://doi.org/10.21203/rs.3.rs-1776256/v1
Autor:
Izabela P. Klaska, Christine Mölzer, S. Le Sommer, Lucia Kuffova, Maria Christofi, John V. Forrester
Publikováno v:
Cellular and Molecular Life Sciences
Cell therapies for autoimmune diseases using tolerogenic dendritic cells (tolDC) have been promisingly explored. A major stumbling block has been generating stable tolDC, with low risk of converting to mature immunogenic DC (mDC), exacerbating diseas
Autor:
Izabela P. Klaska, Anne White, Pilar Villacampa, Justin Hoke, Laura Abelleira-Hervas, Ryea N. Maswood, Robin R. Ali, Catey Bunce, Richard D. Unwin, Garth J.S. Cooper, Paul N. Bishop, James W. Bainbridge
Publikováno v:
Experimental eye research. 215
Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investi
Autor:
Robin R. Ali, Maeve Barlow, James W B Bainbridge, Enrico Cristante, Sidath E. Liyanage, Yanai Duran, Pilar Villacampa, Katja E. Menger, Laura Abelleira-Hervas, Izabela P Klaska, Robert D. Sampson, Ulrich F O Luhmann, Alexander J. Smith
Publikováno v:
Angiogenesis
The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascul
Autor:
Heather M. Wilson, Koju Kamoi, Izabela P. Klaska, Richard J. Cornall, Yi-Hsia Liu, Lucia Kuffova, Kimmo Makinen, Delyth M. Reid, Clare L C Corbett, John V. Forrester, Christine Mölzer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU) model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the promoter for interphotoreceptor retinol binding protein (IRBP). We pr
Autor:
James W B Bainbridge, Richard D. Unwin, Izabela P Klaska, Paul N. Bishop, John R. Griffiths, Garth J. S. Cooper, Eva M. del Amo, Justin Hoke, Leon Aarons, Anne White
Publikováno v:
Del Amo, E M, Griffiths, J R, Klaska, I P, Hoke, J, White, A, Aarons, L, Cooper, G J S, Bainbridge, J W B, Bishop, P N & Unwin, R D 2020, ' Intravitreal pharmacokinetic study of the anti-angiogenic glycoprotein opticin ', Molecular Pharmaceutics . https://doi.org/10.1021/acs.molpharmaceut.0c00151
Molecular Pharmaceutics
Molecular Pharmaceutics
Opticin is an endogenous vitreous glycoprotein that may have therapeutic potential as it has been shown that supra-normal concentrations supress preretinal neovascularisation. Herein we investigated the pharmacokinetics of opticin following intravitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d8c4f7ff403a727127c27cc71e1ce4
https://doi.org/10.1021/acs.molpharmaceut.0c00151
https://doi.org/10.1021/acs.molpharmaceut.0c00151
Autor:
Cristina Martin-Granados, Alan R Prescott, Nele Van Dessel, Aleyde Van Eynde, Miguel Arocena, Izabela P Klaska, Janina Görnemann, Monique Beullens, Mathieu Bollen, John V Forrester, Colin D McCaig
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40769 (2012)
Electrical gradients are present in many developing and regenerating tissues and around tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of many cell types. Intriguingly, specific cell types migrate cathoda
Externí odkaz:
https://doaj.org/article/53b1d6947e134e6aafbff575c15b6ec8
Autor:
Izabela P. Klaska, Cristina Martin-Granados, John V. Forrester, Elizabeth Muckersie, Maria Christofi
Publikováno v:
Immunology
Summary Exposure of bone‐marrow‐derived dendritic cells (BMDC) to high‐dose ultrapure lipopolysaccharide for 24 hr (LPS‐primed BMDC) enhances their potency in preventing inter‐photoreceptor retinoid binding protein: complete Freund's adjuva