Combined effect of the pro-apoptotic rhTRAIL protein and HSV-1 virus in head and neck cancer cell lines

Autor: Lucas Bravo Perina, Izabela Natalia Faria Gomes, Ana Rúbia Alcantara Pelloso, Viviane Aline Oliveira Silva, Lidia Maria Rebolho Batista Arantes, Matias Eliseo Melendez

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Knowledge on the molecular and clinical characteristics of head and neck squamous cell carcinoma (HNSCC) is vast. However, an effective therapy that increases the life expectancy of these patients, with a 5-year overall survival of 50%, is s

Externí odkaz: https://doaj.org/article/d14b1f3e30bf481fafeb52ea7c362b0b

The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death

Autor: Diego Luis Ribeiro, Katiuska Tuttis, Larissa Cristina Bastos de Oliveira, Juliana Mara Serpeloni, Izabela Natalia Faria Gomes, André van Helvoort Lengert, Cláudia Quintino da Rocha, Rui Manuel Reis, Ilce Mara de Syllos Cólus, Lusânia Maria Greggi Antunes

Publikováno v: Pharmaceutics, Vol 14, Iss 5, p 963 (2022)

Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents. Brachydin A (BrA), a glycosylated flavonoid extracted from Fridericia platyphylla, displays a remarkable antitumoral effect against in vitro mPCa cells cultured as bid

Externí odkaz: https://doaj.org/article/4103b00b4aa24c56aa0ab2528370ac2c

Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors

Autor: Luiz Fernando Lopes, Rui Manuel Reis, Mariana Tomazini Pinto, Daniel Onofre Vidal, Ana Carolina Laus, Luciane Sussuchi da Silva, Tiago Alexandre Tassinari, Aline Oliveira da Rocha, Maria Fernanda Santiago Gonçalves, Lais Machado de Jesus, Izabela Natalia Faria Gomes, Eduardo Ramos Martins Cabral, Leticia do Nascimento Braga Pereira, André van Helvoort Lengert

Publikováno v: Frontiers in bioscience (Landmark edition). 27(8)

Testicular germ cell tumors (TGCTs), a group of heterogeneous neoplasms, are the most frequent tumors of teenagers and young men, with the incidence rising worldwide. High cure rates can be achieved through cisplatin (CDDP)-based treatment, but appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313a251980c82b8b0df34ee861208096
https://pubmed.ncbi.nlm.nih.gov/36042160

Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

Autor: Renato José da Silva-Oliveira, Izabela Natalia Faria Gomes, Luciane Sussuchi da Silva, André van Helvoort Lengert, Ana Carolina Laus, Matias Eliseo Melendez, Carla Carolina Munari, Fernanda de Paula Cury, Giovanna Barbarini Longato, Rui Manuel Reis

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7774

Background: EGFR mutations are present in approximately 15–50% of non-small cell lung cancer (NSCLC), which are predictive of anti-EGFR therapies. At variance, NSCLC patients harboring KRAS mutations are resistant to those anti-EGFR approaches. Afa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a454880bf9067c72504514b8b78a343
https://doi.org/10.3390/ijms23147774

Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness

Autor: Adriana Cruvinel Carloni, Izabela Natalia Faria Gomes, Maria Luisa Corcoll Spina, Isabela Werneck da Cunha, Rui Manuel Reis, Lucas Tadeu Bidinotto, Ana Laura V. Alves, Weder Pereira de Menezes, Chris Jones, Viviane Aline Oliveira Silva, Glaucia N. M. Hajj, Carlos Clara, Gisele Caravina de Almeida, Marcela N. Rosa, Matias Eliseo Melendez, Luciane Sussuchi da Silva

Publikováno v: Cells
Cells, Vol 9, Iss 2, p 492 (2020)
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b083fd0c00df5b72b40528f26b329bdc
https://pubmed.ncbi.nlm.nih.gov/32093414