Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Iyo Otsuka"'
Autor:
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune res
Externí odkaz:
https://doaj.org/article/b20ff092b5244208bc65b09380250c63
Autor:
Takuya Yamaguchi, Ikumi Katano, Iyo Otsuka, Ryoji Ito, Misa Mochizuki, Motohito Goto, Takeshi Takahashi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite recent advances in immunodeficient mouse models bearing human red blood cells (hRBCs), the elimination of circulating hRBCs by residual innate immune systems remains a significant challenge. In this study, we evaluated the role of mouse compl
Externí odkaz:
https://doaj.org/article/21811b9530d34276b0c169803db5834e
Autor:
Iyo Otsuka, Motohito Goto, Takuya Yamaguchi, Misa Mochizuki, Ikumi Katano, Ryoji Ito, Takeshi Takahashi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Despite recent advances in immunodeficient mouse models bearing human red blood cells (hRBCs), the elimination of circulating hRBCs by residual innate immune systems remains a significant challenge. In this study, we evaluated the role of mouse compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10454a0ddbbe7f876452b00c52999cd
https://doi.org/10.3389/fimmu.2021.671648
https://doi.org/10.3389/fimmu.2021.671648
Autor:
Motohito Goto, Kenji Kawai, Iyo Otsuka, Riichi Takahashi, Mamoru Ito, Takeshi Takahashi, Mika Yagoto, Asami Hanazawa, Ryoji Ito, Ikumi Katano, Tomoyuki Ogura
Publikováno v:
Biochemical and Biophysical Research Communications. 516:480-485
Although Th17 cells are closely linked to cutaneous graft-versus-host-disease (GVHD) in mouse models, this association remains unclear in human GVHD. In this study, we established a novel xenogeneic cutaneous GVHD model using humanized mice. To induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b9e4e9c5612caa031362d9d6d6f12a
https://doi.org/10.1016/j.bbrc.2019.06.094
https://doi.org/10.1016/j.bbrc.2019.06.094
Autor:
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochiduki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Publikováno v:
Cancer Research. 82:6026-6026
Humanized mice with human hematopoietic and immune systems have been frequently used for examining in vivo anti-cancer effects of various drugs, including immune checkpoint inhibitors (ICIs) like anti-PD-1 or anti-CTLA-4 antibodies, yet the reliabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d9671b18cfe2e5604f40b83687f920
https://doi.org/10.1158/1538-7445.am2022-6026
https://doi.org/10.1158/1538-7445.am2022-6026
Autor:
Takahiro Kagawa, Motohito Goto, Kenji Kawai, Takeshi Takahashi, Ryoji Ito, Iyo Otsuka, Ikumi Katano, Takuya Yamaguchi, Asami Hanazawa, Misa Mochizuki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d9c4a17d4451f5628c0b535e8663ca
https://pubmed.ncbi.nlm.nih.gov/34702924
https://pubmed.ncbi.nlm.nih.gov/34702924
Autor:
Iyo Otsuka, Peter J Simons, Hiroshi Suemizu, Ryoji Ito, Takeshi Takahashi, Ikumi Katano, Mamoru Ito
Publikováno v:
International immunology. 33(3)
Food allergy is a common disease caused by intake of allergen-containing foods, such as milk, eggs, peanuts and wheat. Systemic anaphylaxis is a severe hypersensitive allergic reaction resulting from degranulation of mast cells or basophils after cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ede4eaea4611fbc5e66540047f5ca6c
https://pubmed.ncbi.nlm.nih.gov/33027513
https://pubmed.ncbi.nlm.nih.gov/33027513
Publikováno v:
The Journal of Immunology. 204:66.23-66.23
Background Food allergy is a common disease that is caused by intake of allergen-containing foods such as milk, eggs, peanuts, and wheat. Systemic anaphylaxis is a severe hypersensitive allergic reaction resulting from degranulation of mast cells or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c452d59285cee48215e4b429be0482
https://doi.org/10.4049/jimmunol.204.supp.66.23
https://doi.org/10.4049/jimmunol.204.supp.66.23