A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Autor: Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN, Summers, KM, German, AJ, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Söder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, GSH, O'Rahilly, S

Publikováno v: Raffan, E, Dennis, R J, O'Donovan, C J, Becker, J M, Scott, R A, Smith, S P, Withers, D J, Wood, C J, Conci, E, Clements, D N, Summers, K, German, A J, Mellersh, C S, Arendt, M L, Iyemere, V P, Withers, E, Soder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, G S H & O'Rahilly, S 2016, ' A deletion in the canine POMC gene is associated with weight and appetite in obesity prone Labrador retriever dogs ', Cell Metabolism, vol. 23, no. 5, pp. 893-900 . https://doi.org/10.1016/j.cmet.2016.04.012
Cell Metabolism

Summary Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associa

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