Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Iwona Winiecka"'
2
Novel renin inhibitors containing derivatives of N-alkylleucyl-β -hydroxy-γ -amino acids
Autor: Dorota Marszałek, Aleksander P. Mazurek, Anna Goldnik, Paweł Jaworski, Iwona Winiecka, Daniel Sokulski
Publikováno v: Journal of Peptide Science. 22:106-115
In search for new drugs lowering arterial blood pressure, which could be applied in anti-hypertensive therapy, research concerning agents blocking of renin-angiotensin-aldosteron system has been conducted. Despite many years of research conducted at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c4d05a7785ac208660373aa98d53fc7
https://doi.org/10.1002/psc.2846
Zobrazit plný text záznamu
3
NEW RENIN INHIBITORS - STABILITY AND ACTIVITY DETERMINATION. PART IV
Autor: Dorota, Marszalek, Anna, Goldnik, Iwona, Winiecka, Pawel, Jaworsk, Mazurek Aleksander P
Publikováno v: Acta poloniae pharmaceutica. 74(2)
A series of new seven potential renin inhibitors containing pseudodipeptides were synthesized. Stability for all compounds (1-7) in homogenates of liver, kidney, lung and in serum, gastric, intestinal juice and in the presence of α-chymotrypsin was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68e596f84f732e79ac475359369940db
https://pubmed.ncbi.nlm.nih.gov/29624244
Zobrazit plný text záznamu
4
NEW RENIN-INHIBITORS--STABILITY AND ACTIVITY DETERMINATION. PART III
Autor: Dorota, Marszałek, Anna, Goldnik, Iwona, Winiecka, Paweł, Jaworski, Aleksander P, Mazurek
Publikováno v: Acta poloniae pharmaceutica. 73(2)
A series of new four potential renin inhibitors containing pseudodipeptides were synthesized. Stability for all compounds (1-4) in homogenates of liver, kidney, lung and in serum, gastric, intestinal juice and in the presence of α-chymotrypsin was d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::584119eed60e4413bc2bcbeb8a779439
https://pubmed.ncbi.nlm.nih.gov/27180425
Zobrazit plný text záznamu
5
Novel renin inhibitors containing derivatives of N-alkylleucyl-β-hydroxy-γ-amino acids
Autor: Iwona, Winiecka, Paweł, Jaworski, Aleksander Paweł, Mazurek, Dorota, Marszałek, Anna, Goldnik, Daniel, Sokulski
Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 22(2)
In search for new drugs lowering arterial blood pressure, which could be applied in anti-hypertensive therapy, research concerning agents blocking of renin-angiotensin-aldosteron system has been conducted. Despite many years of research conducted at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b383fb70c5c1fba020697bb27940073
https://pubmed.ncbi.nlm.nih.gov/26780837
Zobrazit plný text záznamu
6
New renin inhibitors--stability and activity determination. Part I
Autor: Dorota, Marszałek, Anna, Goldnik, Aleksander P, Mazurek, Iwona, Winiecka, Paweł, Jaworskpi
Publikováno v: Acta poloniae pharmaceutica. 71(4)
A series of new six potential renin inhibitors containing pseudodipeptides were synthesized. Stability for all compounds (1-6) in homogenates of liver, kidney, lung and in serum, gastric, intestinal juice and in the presence of alpha-chymotrypsin was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83184e77ad57f568298e6dbe10b62907
https://pubmed.ncbi.nlm.nih.gov/25272881
Zobrazit plný text záznamu
7
New renin inhibitors containing phenylalanylhistidyl-gamma-amino acid derivatives in P3 - P1' position
Autor: Iwona, Winiecka, Dorota, Marszałek, Anna, Goldnik, Paweł, Jaworski, Aleksander P, Mazurek
Publikováno v: Acta poloniae pharmaceutica. 71(1)
Five potential inhibitors of renin have been designed and obtained. In the molecule position P3 - P1', crucial for indicating inhibitory activity, all contain phenylalanylhistidylaminoalcanoyl group, ready for interaction with the hydrophobic pocket
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83e6f3b60a68d2d022e1efae312a0454
https://pubmed.ncbi.nlm.nih.gov/24779195
Zobrazit plný text záznamu
8
New potential renin inhibitors with dipeptide replacements in the molecule
Autor: Iwona, Winiecka, Jadwiga, Dudkiewicz-Wilczyńska, Iza, Roman, Ryszard, Paruszewski
Publikováno v: Acta poloniae pharmaceutica. 67(4)
A series of eight non-peptidic potential renin inhibitors have been designed and synthesized. All of them contain dipeptide replacement: (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) in their molecules. Four among them comprise two add
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42b2cc1b927e7cb239561fc56bd19d20
https://pubmed.ncbi.nlm.nih.gov/20635532
Zobrazit plný text záznamu
9
New renin inhibitors with pseudodipeptidic units in P(1)-P(1') and P(2')-P(3') positions
Autor: Jadwiga Dudkiewicz, Iwona Winiecka, Paweł Jaworski, Ryszard Paruszewski, Jadwiga Tautt
Publikováno v: Chemicalpharmaceutical bulletin. 50(6)
A series of four new potential renin inhibitors has been synthesized. The structure of the compounds was designed in such a way as to produce agents resistant to enzymatic degradation, metabolically stable, possibly potent and with improved oral abso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5457bd7b5680cdda0287e13caa1fe87
https://pubmed.ncbi.nlm.nih.gov/12045347
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje