Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Iwona Wilk-Zasadna"'
Autor:
Lysiane Richert, Tommy B. Andersson, Thomas Cole, David Asturiol, Ursula Müller-Vieira, Sandra Coecke, Andrew Worth, Camilla Bernasconi, Roman Liska, Judy Strickland, Iwona Wilk-Zasadna, Olavi Pelkonen, Christophe Chesne
Publikováno v:
Toxicology in Vitro
CYP enzyme induction is a sensitive biomarker for phenotypic metabolic competence of in vitro test systems; it is a key event associated with thyroid disruption, and a biomarker for toxicologically relevant nuclear receptor-mediated pathways. This pa
Publikováno v:
Toxicology. 332:8-19
Early consideration of the multiplicity of factors that govern the biological fate of foreign compounds in living systems is a necessary prerequisite for the quantitative in vitro-in vivo extrapolation (QIVIVE) of toxicity data. Substantial technolog
Autor:
Dean Smith, Paul Stickings, Marlies Halder, Joerg H.O. Garbe, Anna Szczepanska, Pieter-Jan Serreyn, Harrie L. Glansbeek, Klaus Cussler, Catrina Stirling, Sylvie Uhlrich, Ursula G. Sauer, Martin Bopst, Robin Levis, Katrin Schutte, David John, Iwona Wilk-Zasadna
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 48
This article summarizes the outcome of an international workshop organized by the European Partnership for Alternative Approaches to Animal Testing (EPAA) on Modern science for better quality control of medicinal products: Towards global harmonizatio
Autor:
Gabriele Küsters, Frédéric Y. Bois, Harvey J. Clewell, Eva Maria Collnot, Lucian Romeo Farcal, Walter Diembeck, Ursula Gundert-Remy, Emanuela Testai, Kannan Krishnan, Liesbeth Geraets, Klaus Schröder, George Loizou, Iwona Wilk-Zasadna, Camilla Bernasconi, J.G.M. Bessems, José Manuel Zaldívar-Comenges, Sofia B. Leite, Nynke I. Kramer, Sandra Coecke, Olavi Pelkonen
Publikováno v:
Regulatory Toxicology and Pharmacology; Vol 68
Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology
Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). D
Autor:
Sandra, Coecke, Camilla, Bernasconi, Gerard, Bowe, Ann-Charlotte, Bostroem, Julien, Burton, Thomas, Cole, Salvador, Fortaner, Varvara, Gouliarmou, Andrew, Gray, Claudius, Griesinger, Susanna, Louhimies, Emilio Mendoza-de, Gyves, Elisabeth, Joossens, Maurits-Jan, Prinz, Anne, Milcamps, Nicholaos, Parissis, Iwona, Wilk-Zasadna, João, Barroso, Bertrand, Desprez, Ingrid, Langezaal, Roman, Liska, Siegfried, Morath, Vittorio, Reina, Chiara, Zorzoli, Valérie, Zuang
Publikováno v:
Advances in experimental medicine and biology. 856
This chapter focuses on practical aspects of conducting prospective in vitro validation studies, and in particular, by laboratories that are members of the European Union Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) t
Autor:
Andrew Gray, Siegfried Morath, Maurits-Jan Prinz, Camilla Bernasconi, Iwona Wilk-Zasadna, Julien Burton, Elisabeth Joossens, Ann-Charlotte Bostroem, Vittorio Reina, João Barroso, Bertrand Desprez, Claudius Griesinger, Varvara Gouliarmou, Gerard Bowe, Thomas Cole, Ingrid Langezaal, Emilio Mendoza-de Gyves, Salvador Fortaner, Nicholaos Parissis, Valérie Zuang, Chiara Zorzoli, Susanna Louhimies, Anne Milcamps, Roman Liska, Sandra Coecke
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319338248
This chapter focuses on practical aspects of conducting prospective in vitro validation studies, and in particular, by laboratories that are members of the European Union Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c6c32247cfa9303562af0cc99449ed
https://doi.org/10.1007/978-3-319-33826-2_5
https://doi.org/10.1007/978-3-319-33826-2_5
Autor:
Salvador Fortaner, Ann-Charlotte Bostroem, Sandra Coecke, Gilles Bories, Iwona Wilk-Zasadna, Gerard Bowe, Anne Milcamps, Maurice Whelan, Roman Liska, Emilio Mendoza, Siegfried Morath, Camilla Bernasconi, Vittorio Reina, Varvara Gouliarmou, Jean-Michel Gineste, Ingrid Langezaal
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493905201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a07f1e5cb966daf69cdea632978d4b6
https://doi.org/10.1007/978-1-4939-0521-8_25
https://doi.org/10.1007/978-1-4939-0521-8_25
Autor:
Jos G, Bessems, George, Loizou, Kannan, Krishnan, Harvey J, Clewell, Camilla, Bernasconi, Frederic, Bois, Sandra, Coecke, Eva-Maria, Collnot, Walter, Diembeck, Lucian Romeo, Farcal, Liesbeth, Geraets, Ursula, Gundert-Remy, Nynke, Kramer, Gabriele, Küsters, Sofia B, Leite, Olavi R, Pelkonen, Klaus, Schröder, Emanuela, Testai, Iwona, Wilk-Zasadna, José-Manuel, Zaldívar-Comenges
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 68(1)
Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). D
Autor:
Christopher Chesne, Paula M. Alves, Elodie Airola, Christiane Guguen-Guillouzo, Sofia B. Leite, Iwona Wilk-Zasadna, Marcos A. Reis-Fernandes, Milena Mennecozzi, Jose M. Zaldivar, Sandra Coecke, Claude Guillou
Publikováno v:
Toxicological Sciences; Vol 130
The culture of HepaRG cells as three dimensional (3D) structures in the spinner-bioreactor may represent added value as a hepatic system for toxicological purposes. The use of a cost-effective commercially available bioreactor, which is compatible wi
Autor:
Maria Minta, Iwona Wilk-Zasadna
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 10; Issue 1; Pages: 37-49
International Journal of Molecular Sciences, Vol 10, Iss 1, Pp 37-49 (2008)
International Journal of Molecular Sciences; Volume 10; Issue 1; Pages: 37-49
International Journal of Molecular Sciences, Vol 10, Iss 1, Pp 37-49 (2008)
Embryonic midbrain micromass cultures were exposed for five days to ochratoxin A (OTA) at seven concentrations (ranging from 0.16 to 10 microg/mL). Cell viability was assessed in neutral red uptake test (NRU), and differentiation - by immunoenzymatic