Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Iwona Wala"'
A non-radioactive method for detecting neutralizing antibodies against therapeutic proteins in serum
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 45:583-589
The presence of neutralizing antibodies against protein therapeutics continues to cause concern in the biomedical field. These antibodies not only reduce the efficacy of the protein therapeutics, but may also block the normal function of their endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdd7321ce02fcfa1c9057b8dfecfa84
https://doi.org/10.1016/j.jpba.2007.08.005
https://doi.org/10.1016/j.jpba.2007.08.005
Autor:
Janice Nagatani, Francesca Civoli, Yao Zhuang, Iwona Wala, Arunan Kaliyaperumal, Hong Han, Troy E. Barger, Jenny Hu, Shalini Gupta
Publikováno v:
Journal of immunological methods. 419
Anti-drug neutralizing antibodies (NAbs) formed due to unwanted immunogenicity of a therapeutic protein point towards a mature immune response. NAb detection is important in interpreting the therapeutic's efficacy and safety in vivo. In vitro cell-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb275117e7b9e59b87ce226465a4f4
https://pubmed.ncbi.nlm.nih.gov/25795420
https://pubmed.ncbi.nlm.nih.gov/25795420
Autor:
Iwona Wala, Collins David S, Stephen Kaufman, Catherine L. Farrell, David C. Litzinger, Jeffrey M. Brown, Gwyneth Y. han
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1281:139-149
The present studies describe the biodistribution of cationic liposomes and cationic liposome/oligonucleotide complex following intravenous injection into mice via the tail vein. (111)In-diethylenetriaminepentaacetic acid stearylamide ((111)In-DTPA-SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b443955d0ba1dc003c0ed8c53c543a95
https://doi.org/10.1016/0005-2736(95)00268-5
https://doi.org/10.1016/0005-2736(95)00268-5
Publikováno v:
Journal of immunological methods. 308(1-2)
Neutralizing antibodies against therapeutic proteins can be potentially harmful if the antibody blocks not only the therapeutic activities of the therapeutic protein but also the normal functions of the endogenous counterpart. Detection of the neutra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb8a90d45ac2e42829a5d35eaeedb5d
https://pubmed.ncbi.nlm.nih.gov/16356511
https://pubmed.ncbi.nlm.nih.gov/16356511