Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Iwona Ruchala"'
Autor:
Iwona, Ruchala, Umberto M, Battisti, Vy T, Nguyen, Rita Yu-Tzu, Chen, Richard A, Glennon, Jose M, Eltit
Publikováno v:
Toxicol Appl Pharmacol
The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug
Autor:
Umberto Maria Battisti, Michael H. Baumann, Donna Walther, Iwona Ruchala, Farhana Sakloth, Jose M. Eltit, Richard A. Glennon, Sidney S. Negus, Alan S. Harris, Ramsey Sitta
Publikováno v:
ACS Chemical Neuroscience. 9:1829-1839
4-Methylamphetamine (4-MA) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), thereby causing non-exocytotic release of monoamine transmitters via reve
Autor:
Richard A. Glennon, Iwona Ruchala, Jose M. Eltit, Rita Yu-Tzu Chen, Vy T. Nguyen, Umberto Maria Battisti
Publikováno v:
Toxicology and Applied Pharmacology. 419:115513
The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug
Autor:
Michael H. Baumann, John S. Partilla, S. Stevens Negus, Farhana Sakloth, Ernesto Solis, Kathryn L. Schwienteck, Iwona Ruchala, Louis J. De Felice, Richard A. Glennon, Jose M. Eltit
Publikováno v:
Neuropsychopharmacology. 42:1950-1961
Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging
Autor:
Aaron Corbin-Leftwich, Junghoon Ha, Audrey Le, Sayeed M. Mossadeq, Carlos A. Villalba-Galea, Iwona Ruchala
Publikováno v:
The Journal of General Physiology
Researchers studied the mechanism by which the anticonvulsant Retigabine enhances the activity of K+ channels and found that the drug stabilizes on open state at resting membrane potentials.
The anticonvulsant Retigabine is a KV7 channel agonist
The anticonvulsant Retigabine is a KV7 channel agonist
Amphetamine (AMPH) and its more potent enantiomer S(+)AMPH are psychostimulants used therapeutically to treat attention deficit hyperactivity disorder and have significant abuse liability. AMPH is a dopamine transporter (DAT) substrate that inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e64f4492a4998f9a6bfc5835383c18
https://europepmc.org/articles/PMC4631700/
https://europepmc.org/articles/PMC4631700/
Publikováno v:
Biophysical Journal. 112:337a
The dopamine, serotonin, and norepinephrine transporters are important determinants of monoaminergic neurotransmission. The pharmacological manipulation of these systems contributes not only to drug addiction, but also to the treatment of many mental
Autor:
Vanessa Cabra, Louis J. De Felice, Iwona Ruchala, Jose M. Eltit, Richard A. Glennon, Ernesto Solis
Monoamine transporters have been implicated in dopamine or serotonin release in response to abused drugs such as methamphetamine or ecstasy (MDMA). In addition, monoamine transporters show substrate-induced inward currents that may modulate excitabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1919cd7b4f252ddf748f62591922a2c
https://europepmc.org/articles/PMC4052380/
https://europepmc.org/articles/PMC4052380/
Publikováno v:
Biophysical Journal. 108:462a-463a
Monoamine transporters take up neurotransmitters, but they also release neurotransmitters when challenged by abused drugs like amphetamine (AMPH) or MDMA (ecstasy). Transported substrates including transmitters and drugs are accompanied by excess pos