Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Iwona Ruchala"'
Autor:
Iwona, Ruchala, Umberto M, Battisti, Vy T, Nguyen, Rita Yu-Tzu, Chen, Richard A, Glennon, Jose M, Eltit
Publikováno v:
Toxicol Appl Pharmacol
The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2e399ae0f710edb1868993baa1cf2c6
https://pubmed.ncbi.nlm.nih.gov/33785354
https://pubmed.ncbi.nlm.nih.gov/33785354
Autor:
Umberto Maria Battisti, Michael H. Baumann, Donna Walther, Iwona Ruchala, Farhana Sakloth, Jose M. Eltit, Richard A. Glennon, Sidney S. Negus, Alan S. Harris, Ramsey Sitta
Publikováno v:
ACS Chemical Neuroscience. 9:1829-1839
4-Methylamphetamine (4-MA) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), thereby causing non-exocytotic release of monoamine transmitters via reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d5d7864eadf9e04f213a772a682fa2
https://doi.org/10.1021/acschemneuro.8b00138
https://doi.org/10.1021/acschemneuro.8b00138
Autor:
Michael H. Baumann, John S. Partilla, S. Stevens Negus, Farhana Sakloth, Ernesto Solis, Kathryn L. Schwienteck, Iwona Ruchala, Louis J. De Felice, Richard A. Glennon, Jose M. Eltit
Publikováno v:
Neuropsychopharmacology. 42:1950-1961
Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a328bddfdf60d37d43eec0f2a198dc0
https://doi.org/10.1038/npp.2017.98
https://doi.org/10.1038/npp.2017.98
Autor:
Richard A. Glennon, Iwona Ruchala, Jose M. Eltit, Rita Yu-Tzu Chen, Vy T. Nguyen, Umberto Maria Battisti
Publikováno v:
Toxicology and Applied Pharmacology. 419:115513
The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61c083a2a1b3899d91380665a74f2f0
https://doi.org/10.1016/j.taap.2021.115513
https://doi.org/10.1016/j.taap.2021.115513
Autor:
Aaron Corbin-Leftwich, Junghoon Ha, Audrey Le, Sayeed M. Mossadeq, Carlos A. Villalba-Galea, Iwona Ruchala
Publikováno v:
The Journal of General Physiology
Researchers studied the mechanism by which the anticonvulsant Retigabine enhances the activity of K+ channels and found that the drug stabilizes on open state at resting membrane potentials.
The anticonvulsant Retigabine is a KV7 channel agonist
The anticonvulsant Retigabine is a KV7 channel agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f03fff99267d43f1535aea65022831
http://europepmc.org/articles/PMC4772374
http://europepmc.org/articles/PMC4772374
Amphetamine (AMPH) and its more potent enantiomer S(+)AMPH are psychostimulants used therapeutically to treat attention deficit hyperactivity disorder and have significant abuse liability. AMPH is a dopamine transporter (DAT) substrate that inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e64f4492a4998f9a6bfc5835383c18
https://europepmc.org/articles/PMC4631700/
https://europepmc.org/articles/PMC4631700/
Publikováno v:
Biophysical Journal. 112:337a
The dopamine, serotonin, and norepinephrine transporters are important determinants of monoaminergic neurotransmission. The pharmacological manipulation of these systems contributes not only to drug addiction, but also to the treatment of many mental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db7546f80a348a705a6dbb6273000c48
https://doi.org/10.1016/j.bpj.2016.11.1822
https://doi.org/10.1016/j.bpj.2016.11.1822
Autor:
Vanessa Cabra, Louis J. De Felice, Iwona Ruchala, Jose M. Eltit, Richard A. Glennon, Ernesto Solis
Monoamine transporters have been implicated in dopamine or serotonin release in response to abused drugs such as methamphetamine or ecstasy (MDMA). In addition, monoamine transporters show substrate-induced inward currents that may modulate excitabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1919cd7b4f252ddf748f62591922a2c
https://europepmc.org/articles/PMC4052380/
https://europepmc.org/articles/PMC4052380/
Publikováno v:
Biophysical Journal. 108:462a-463a
Monoamine transporters take up neurotransmitters, but they also release neurotransmitters when challenged by abused drugs like amphetamine (AMPH) or MDMA (ecstasy). Transported substrates including transmitters and drugs are accompanied by excess pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca9f6c00f9e45eb85462af11903432a
https://doi.org/10.1016/j.bpj.2014.11.2523
https://doi.org/10.1016/j.bpj.2014.11.2523