Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Iwona J Fijalkowska"'
Autor:
Malgorzata Jedrychowska, Milena Denkiewicz-Kruk, Malgorzata Alabrudzinska, Adrianna Skoneczna, Piotr Jonczyk, Michal Dmowski, Iwona J Fijalkowska
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008494 (2019)
Faithful replication and repair of DNA lesions ensure genome maintenance. During replication in eukaryotic cells, DNA is unwound by the CMG helicase complex, which is composed of three major components: the Cdc45 protein, Mcm2-7, and the GINS complex
Externí odkaz:
https://doaj.org/article/4e4502278d9841618e31147cc67f253b
Autor:
Krystian Łazowski, Mahmood Faraz, Alexandra Vaisman, Nicholas W Ashton, Piotr Jonczyk, Iwona J Fijalkowska, Anders R Clausen, Roger Woodgate, Karolina Makiela-Dzbenska
Publikováno v:
Nucleic Acids Res
In Escherichia coli, replication of both strands of genomic DNA is carried out by a single replicase—DNA polymerase III holoenzyme (pol III HE). However, in certain genetic backgrounds, the low-fidelity TLS polymerase, DNA polymerase V (pol V) gain
Autor:
Michal, Dmowski, Karolina, Makiela-Dzbenska, Malgorzata, Jedrychowska, Milena, Denkiewicz-Kruk, Iwona J, Fijalkowska
Publikováno v:
Data in brief. 42
DNA replication in
Publikováno v:
Environmental and Molecular Mutagenesis
Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli , this inducible system is
Autor:
Hiroyuki Araki, Shizuko Endo, Piotr Jonczyk, Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Michał Dmowski, Iwona J. Fijalkowska
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9484, p 9484 (2020)
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9484, p 9484 (2020)
Volume 21
Issue 24
The CMG complex (Cdc45, Mcm2&ndash
7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol &epsilon
) is essential
7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol &epsilon
) is essential
Autor:
Michal Dmowski, Malgorzata Jedrychowska, Karolina Makiela-Dzbenska, Milena Denkiewicz-Kruk, Sushma Sharma, Andrei Chabes, Hiroyuki Araki, Iwona J. Fijalkowska
Publikováno v:
DNA Repair. 110:103272
DNA replication is performed by replisome proteins, which are highly conserved from yeast to humans. The CMG [Cdc45-Mcm2–7-GINS(Psf1–3, Sld5)] helicase unwinds the double helix to separate the leading and lagging DNA strands, which are replicated
Publikováno v:
Current Genetics
Precisely controlled mechanisms have been evolved to rescue impeded DNA replication resulting from encountered obstacles and involve a set of low-fidelity translesion synthesis (TLS) DNA polymerases. Studies in recent years have brought new insights
Publikováno v:
Molecular Microbiology. 106:659-672
Eukaryotic DNA replication is performed by high-fidelity multi-subunit replicative B-family DNA polymerases (Pols) α, δ and ɛ. Those complexes are composed of catalytic and accessory subunits and organized in multicomplex machinery: the replisome.
Autor:
Michał Dmowski, Iwona J. Fijalkowska
Publikováno v:
Current Genetics
Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated prote
Autor:
Sarah S. Henrikus, Andrew Robinson, Krystian Łazowski, Thomas J. Armstrong, Antoine M. van Oijen, Alexandra Vaisman, John P. McDonald, Erin Walsh, Iwona J. Fijalkowska, Roger Woodgate, Piotr Jonczyk, Myron F. Goodman, Karolina Makiela-Dzbenska
Publikováno v:
DNA Repair (Amst)
pol V(ICE391) (RumA′(2)B) is a low-fidelity polymerase that promotes considerably higher levels of spontaneous “SOS-induced” mutagenesis than the related E. coli pol V (UmuD′2C). The molecular basis for the enhanced mutagenesis was previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49879ae9dc442bf18114ff891b927b33
https://europepmc.org/articles/PMC6901709/
https://europepmc.org/articles/PMC6901709/