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Akademický článek

Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

Autor: Iwona Dams, Anna Ostaszewska, Maria Puchalska, Justyna Chmiel, Piotr Cmoch, Iwona Bujak, Agata Białońska, Wojciech J. Szczepek

Publikováno v: Molecules, Vol 20, Iss 12, Pp 21346-21363 (2015)

During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identifie

Externí odkaz: https://doaj.org/article/597524469ce24822a97c25c3abeac4a0

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Akademický článek

New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

Autor: Olga Michalak, Marta Łaszcz, Kamil Jatczak, Anna Witkowska, Iwona Bujak, Aleksandra Groman, Marcin Cybulski

Publikováno v: Molecules, Vol 20, Iss 8, Pp 13814-13829 (2015)

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and che

Externí odkaz: https://doaj.org/article/0c3e25990362450899db3321f5fbf416

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Akademický článek

Synthesis and Physicochemical Characterization of the Impurities of Pemetrexed Disodium, an Anticancer Drug

Autor: Olga Michalak, Mariusz M. Gruza, Anna Witkowska, Iwona Bujak, Piotr Cmoch

Publikováno v: Molecules, Vol 20, Iss 6, Pp 10004-10031 (2015)

A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structur

Externí odkaz: https://doaj.org/article/284bc906aec946baa382f3166ca5d3bc

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An efficient synthesis of indolo[2,3-b]quinoline guanidine derivatives with their in vitro and in vivo study

Autor: Marcin Cybulski, Bartłomiej Żerek, Katarzyna Sidoryk, Piotr Rózga, Marta Świtalska, Iwona Bujak, Joanna Wietrzyk, Łukasz Kaczmarek

Publikováno v: Medicinal Chemistry Research

An optimization of the guanidylation process by verifying the efficacy of common guanylation reagents in order to obtain the guanidine derivatives of indolo[2,3-b]quinoline has been performed. As a result, a high-yield procedure using N,N′-di-Boc-N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd797ee6ca3de69d300893b0212652b
https://doi.org/10.1007/s00044-017-2028-1

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Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

Autor: Agata Białońska, Piotr Cmoch, Chmiel Justyna, Iwona Dams, Anna Ostaszewska, Maria Puchalska, Iwona Bujak, Wojciech Szczepek

Publikováno v: Molecules
Volume 20
Issue 12
Pages 21346-21363
Molecules, Vol 20, Iss 12, Pp 21346-21363 (2015)
Molecules; Volume 20; Issue 12; Pages: 21346-21363

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2169cc547ac2a115db2cd93119b287f3
https://doi.org/10.3390/molecules201219762

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Synthesis and physicochemical characterization of the impurities and the key intermediate of pemetrexed disodium, an anticancer drug

Autor: Olga Michalak, Marta Łaszcz, Kinga Trzcińska, Anna Witkowska, Iwona Bujak, Piotr Cmoch, Mariusz Gruza

Pemetrexed is an antifolate antineoplastic agent that acts by inhibiting the formation of precursor purine and pyrimidine nucleotides. Pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40c2069657b824a047e0f517eb70181
https://doi.org/10.7287/peerj.preprints.1910v1

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New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

Autor: Aleksandra Groman, Marcin Cybulski, Kamil Jatczak, Iwona Bujak, Olga Michalak, Anna Witkowska, Marta Łaszcz

Publikováno v: Molecules
Volume 20
Issue 8
Pages 13814-13829
Molecules, Vol 20, Iss 8, Pp 13814-13829 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f151fd51b2bac4d1edb3063e144c26f

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