Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Iwo, Kucinski"'
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The vertebrate organizer plays a crucial role in building the main (antero-posterior) axis of the embryo: it neuralizes the surrounding ectoderm, and is the site of emigration for cells making axial and paraxial mesendoderm during elongation. The chi
Externí odkaz:
https://doaj.org/article/1421adc1ae1a4c60afb004f5dd2934e9
Autor:
Michael E. Baumgartner, Paul F. Langton, Remi Logeay, Alex Mastrogiannopoulos, Anna Nilsson-Takeuchi, Iwo Kucinski, Jules Lavalou, Eugenia Piddini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Investigating organ biology often requires methodologies to induce genetically distinct clones within a living tissue. However, the 3D nature of clones makes sample image analysis challenging and slow, limiting the amount of information that
Externí odkaz:
https://doaj.org/article/b431140ebdbd4b4b8ccb044fce0d375a
Autor:
Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001710 (2022)
Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars. Here, we discov
Externí odkaz:
https://doaj.org/article/4566caa47f404199853ee3a3653a5ebf
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling,
Externí odkaz:
https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c199
Autor:
Kyomi J Igarashi, Iwo Kucinski, Yan Yi Chan, Tze-Kai Tan, Hwei Minn Khoo, David Kealy, Joydeep Bhadury, Ian Hsu, Pui Yan Ho, Kouta Niizuma, John W Hickey, Garry Nolan, Katherine S Bridge, Agnieszka Czechowicz, Berthold Gottgens, Hiromitsu Nakauchi, Adam C Wilkinson
Hematopoietic stem cells (HSCs) are a rare hematopoietic cell type that can entirely reconstitute the blood and immune systems following transplantation. Allogeneic HSC transplantation (HSCT) is used clinically as a curative therapy for a range of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2992d2e57974f834d61918b9f9c0247f
https://ora.ox.ac.uk/objects/uuid:2a38be79-3dcb-4a27-a289-044ce34d3cb8
https://ora.ox.ac.uk/objects/uuid:2a38be79-3dcb-4a27-a289-044ce34d3cb8
Autor:
Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells,
Externí odkaz:
https://doaj.org/article/917bfec21e0c49399454b3445695a286
The vertebrate Organizer plays a crucial role in defining the main axes of embryo: it neuralizes the surrounding ectoderm, and is the site of emigration for cells making axial and paraxial mesendoderm during elongation. The chick Organizer becomes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00ce252ba76c50fe0e5accfb8ce5319
https://doi.org/10.1101/2022.12.16.520706
https://doi.org/10.1101/2022.12.16.520706
Autor:
Aurelie Lenaerts, Iwo Kucinski, Ward Deboutte, Marta Derecka, Pierre Cauchy, Thomas Manke, Berthold Göttgens, Rudolf Grosschedl
Publikováno v:
Journal of Experimental Medicine
Funder: Max-Planck-Gesellschaft
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of the blood system. Despite their multipotency, MPPs display poorly understood lineage bias. Here, we examine whether lineage-
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of the blood system. Despite their multipotency, MPPs display poorly understood lineage bias. Here, we examine whether lineage-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c42f52b7b459682827a6d900c3d331
Autor:
Iwo Kucinski, Joana Campos, Melania Barile, Francesco Severi, Natacha Bohin, Pedro N Moreira, Lewis Allen, Hannah Lawson, Myriam L R Haltalli, Sarah J Kinston, Dónal O’Carroll, Kamil R Kranc, Berthold Göttgens
The paradigmatic tree model of hematopoiesis is increasingly recognized to be limited as it is based on heterogeneous populations and largely inferred from non-homeostatic cell fate assays. Here, we combine persistent labeling with time-series single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4f4789657c5489a0058a099cf56c525
https://doi.org/10.1101/2022.09.07.506735
https://doi.org/10.1101/2022.09.07.506735
Autor:
James L C Che, Daniel Bode, Iwo Kucinski, Alyssa H Cull, Fiona Bain, Hans J Becker, Maria Jassinskaja, Melania Barile, Grace Boyd, Miriam Belmonte, Andy G X Zeng, Kyomi J Igarashi, Juan Rubio‐Lara, Mairi S Shepherd, Anna Clay, John E Dick, Adam C Wilkinson, Hiromitsu Nakauchi, Satoshi Yamazaki, Berthold Göttgens, David G Kent
Publikováno v:
EMBO reports. 23(10)
Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not