Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket

Autor: Loevezijn, A. van, Venhorst, J., Iwema Bakker, W.I., Lange, J.H.M., Looff, W. de, Henzen, R., Vries, J. de, Woestijne, R.P. van de, Hartog, A.P. den, Verhoog, S., Neut, M.A.W. van der, Bruin, N.M.W.J. de, Kruse, C.G.

The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently disclosed. Here we describe how this structural class was further developed by addressing an unexplored interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::57a6f24a9befdf9b2469d9451ce3c3bc
https://publica.fraunhofer.de/handle/publica/244646

Kinetically stable alkali cation complexes of calixspherands

Autor: Iwema bakker, W.I., de Haas, M., Verboom, Willem, de Zeeuw, D., Reinhoudt, David

Publikováno v: ISSUE=17;TITLE=17th International Symposium on Macrocyclic Chemistry, ISMC 1992
Bijeenkomst SON-werkgemeenschap Organische Synthese 1992

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6d418a563080d1adb4534acb55538037
https://research.utwente.nl/en/publications/kinetically-stable-alkali-cation-complexes-of-calixspherands(f3424b5e-23df-4c54-a883-1e9f5586a84f).html

Calixspherands as Ligands for the Complexation of Radioactive Rubidium—81

Autor: Iwema Bakker, W.I., Reinhoudt, D.N., Cecille, Messrs L., Casara, M., Pietrelli, L.

Publikováno v: New Separation Chemistry Techniques for Radioactive Waste and Other Specific Applications, 142-149
STARTPAGE=142;ENDPAGE=149;TITLE=New Separation Chemistry Techniques for Radioactive Waste and Other Specific Applications
New Separation Chemistry Techniques for Radioactive Waste and Other Specific Applications ISBN: 9781851666560

For the use in medicine we are interested in ligands that form kinetically stable complexes with radioactive alkali cations. The spherands form very stable complexes with Li+ and Na+, but reject the larger alkali cations like K+ and Rb+. Our objectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087434d4d653d59cbbbd8529bda16a0c
https://doi.org/10.1007/978-94-011-3654-9_20

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