Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Iwao Ojima"'
Autor:
Isabella Dib Ferreira Gremião, Gabriela Reis Pereira-Oliveira, Sandro Antonio Pereira, Maria Lopes Corrêa, Luana Pereira Borba-Santos, Alessandra Lifsitch Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel S. Matos, Vanessa Silva, Cristina Lazzarini, Caroline Mota Fernandes, Kildare Miranda, Jhon Jhamilton Artunduaga Bonilla, Anna Letícia Nunes, Leonardo Nimrichter, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of sporotrichosis. In this study, we demonstrated the anti-fungal e
Externí odkaz:
https://doaj.org/article/9a2aba0c9d7847cbb62ff4a8532b18f8
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catal
Externí odkaz:
https://doaj.org/article/59f2bd7f31734cc8a95f45f55edf0307
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Artificial intelligence (AI) has been widely applied in drug discovery with a major task as molecular property prediction. Despite booming techniques in molecular representation learning, key elements underlying molecular property prediction
Externí odkaz:
https://doaj.org/article/ececa158a6944010a012c93148281a5a
Autor:
Sherrye T. Glaser, Kalani Jayanetti, Saida Oubraim, Andrew Hillowe, Elena Frank, Jason Jong, Liqun Wang, Hehe Wang, Iwao Ojima, Samir Haj-Dahmane, Martin Kaczocha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles and nuclear receptors. More recently, FABP5 has emerged as a key regulator of synaptic endocannabinoid signaling, suggesting that FABPs may broa
Externí odkaz:
https://doaj.org/article/051e942f5eec42278754deaffb2bf38b
Autor:
Tomas Sychra, Alzbeta Spalenkova, Stepan Balatka, Radka Vaclavikova, Karolina Seborova, Marie Ehrlichova, Jaroslav Truksa, Cristian Sandoval-Acuña, Vlasta Nemcova, Arpad Szabo, Kamila Koci, Tereza Tesarova, Lei Chen, Iwao Ojima, Martin Oliverius, Pavel Soucek
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109044- (2024)
Summary: Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most promising way to improv
Externí odkaz:
https://doaj.org/article/a032fb8b23884f2993b71832d334ba03
Autor:
Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V. Airola, Maurizio Del Poeta
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Invasive fungal infections are a leading cause of death in immunocompromised patients. Current therapies have several limitations, and innovative antifungal agents are critically needed. Previously, we identified the fungus-specific enzyme s
Externí odkaz:
https://doaj.org/article/10a62aeb5767483fa4514f5d67e00b54
Autor:
Andrew Hillowe, Chris Gordon, Liqun Wang, Robert C Rizzo, Lloyd C Trotman, Iwao Ojima, Agnieszka Bialkowska, Martin Kaczocha
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292483 (2023)
Prostate cancer is a leading cause of cancer-related deaths in men in the United States. Although treatable when detected early, prostate cancer commonly transitions to an aggressive castration-resistant metastatic state. While taxane chemotherapeuti
Externí odkaz:
https://doaj.org/article/620d251e83954e02a10d8f068f447ba8
Autor:
Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy
Externí odkaz:
https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff
Autor:
Karolina Seborova, Kamila Koucka, Alzbeta Spalenkova, Petr Holy, Marie Ehrlichova, Tomas Sychra, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek, Radka Vaclavikova
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug resistance. New-generation synthetic experimental taxoids (Stony Brook Taxanes; SB-T) have show
Externí odkaz:
https://doaj.org/article/40f498fcbaef46a1889e236533885e53
Autor:
Demosthenes Morales, Sofiya Micheva-Viteva, Samantha Adikari, James Werner, Murray Wolinsky, Elizabeth Hong-Geller, Jinwoo Kim, Iwao Ojima
Publikováno v:
Microorganisms, Vol 10, Iss 10, p 1966 (2022)
Persistence is a bet-hedging strategy in bacterial populations that increases antibiotic tolerance and leads to the establishment of latent infections. In this study, we demonstrated that a synthetic non-toxic taxane-based reversal agent (tRA), devel
Externí odkaz:
https://doaj.org/article/502d27c59d4a4b6090b653c5ab8c8478