Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

Autor: Iwao Komuro, Kiyoko S. Akagawa, Toshio Yamazaki, Keiko Mochida, Fumio Kishi, Hiroko Kanazawa

Publikováno v: Respirology. 11:S32-S36

Macrophages (Mphis) have various functions and play a critical role in host defense and the maintenance of homeostasis. Mphis exist in every tissue in the body, but Mphis from different tissues exhibit a wide range of phenotypes with regard to their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453d1c744db325308009228d0368bb8a
https://doi.org/10.1111/j.1440-1843.2006.00805.x

Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta

Autor: Aikichi Iwamoto, Kiyoko S. Akagawa, Iwao Komuro, Yasuko Yokota, Satoshi Omura, Toshiaki Sunazuka

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(34)

Macrophages (MΦs) are a major source of HIV-1 especially in patients with tuberculosis. There are MΦs that are permissive and those that restrict HIV-1. Regulation of hematopoietic cell kinase (Hck) activity and selective expression of CCAAT enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea66a199224e387062770b9acee4912
https://pubmed.ncbi.nlm.nih.gov/18719105

CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection

Autor: Kiyoko S. Kagawa, Iwao Komuro, Yasuko Yokota, Aikichi Iwamoto, Sachiko Yasuda

Publikováno v: The Journal of Experimental Medicine

Granulocyte/macrophage colony-stimulating factor (GM-CSF)–induced monocyte-derived macrophages (GM-MΦ) are permissive to M-tropic HIV-1 entry, but inhibit viral replication at posttranscriptional and translational levels, whereas M-CSF-induced mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26ceac98554fbf9b1ae7e7e62756760
https://pubmed.ncbi.nlm.nih.gov/12900520

IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages

Autor: Iwao Komuro, Muneo Yamada, Kiyoko S. Akagawa, Shin-ichi Hashimoto

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 167(7)

We previously demonstrated that IL-10 alone does not stimulate growth and differentiation of human monocytes, but enhances those of monocytes stimulated with M-CSF. We studied here the effect of IL-10 on human monocytes stimulated with GM-CSF. Monocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a1d5b49d3fe243b65bda6d35bbb4a
https://pubmed.ncbi.nlm.nih.gov/11564774

[Phase II study of edobacomab (E5) in the treatment of gram-negative sepsis]

Autor: Hiroyuki KOBAYASHI, Shin KAWAI, Susumu SAKAYORI, Masamitsu KANEKO, Yasushi ITO, Yoshihito UJIIE, Kenji KOBAYASHI, Hitoshi IMAIZUMI, Shuitsu HOSHI, Shigeatsu ENDO, Ryouichi MOTOKI, Hitoshi INOUE, Gouichi ENDO, Masaaki ARAKAWA, Kouichi WADA, Hiroyuki HIRASAWA, Shigeto ODA, Hidetoshi SHIGA, Kunio KOBAYASHI, Takashi HIGO, Otohiko KUNII, Yasuo ONO, Hajime NISHIYA, Takeshi SATO, Kyuya ISHIBIKI, Masakazu UEDA, Kaoru SHIMADA, Satoshi KIMURA, Iwao KOMURO, Hajime GOTO, Takashi INAMATSU, Makiko FUKAYAMA, Izumi HAYASHI, Masao ICHIKI, Shuji SHIMAZAKI, Tetsuo YUKIOKA, Shoichi OOTA, Yasuyuki YONEDA, Takashi OOWADA, Katsuhiko SUGIMOTO, Shoichiro IRIMAJIRI, Yasuo OOSONE, Jyun TAKEZAWA, Toshio FUKUOKA, Jirou YURA, Nagao SHINAGAWA, Shu ISHIKAWA, Hirotada KATSUYA, Kiyoshi ISHIKAWA, Toshiyuki YAMAMOTO, Kanzou SUZUKI, Touru MATSUURA, Ikuto YOSHIYA, Nobuyuki TAENAKA, Kikushi KATSURADA, Hiroshi NISHIO, Keiji KUMON, Naoki YAHAGI, Ikuto SAKATA, Jirou MARUYAMA, Hiroshi TANIMURA, Makoto IWAHASHI, Shizuma MIZOBATA, Masahiro SHINOZAKI, Toshio NAKA, Chiiho FUJII, Mitsuhiro FUKUDA, Shinichi ISHIMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Hiroshi TATARA, Takashi YOKOYAMA, Takashi KODAMA, Hiroaki TSUMURA, Katsurou YAGAWA, Nobuo KAKU, Mitsuo SOU, Toshimi TSUNEYOSHI, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Kazunori TOMONO, Yuuichi INOUE, Takakazu OTSUBO, Sadahiro ASAI, Hideo MASHIMOTO, Shouichi SATO, Jun ARAKI, Michio OGAWA, Satoshi IKEI, Masao YOSHIDA, Katsuya INADA, Kenji TADOKORO

Publikováno v: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 68(1)

The efficacy, safety and usefulness of murine anti-endotoxin monoclonal IgM antibody "E5, an intravenous dose of 2 mg/kg" were evaluated in 88 patients with suspected Gram-negative sepsis from 37 institutes in Japan. Out of these, 74 patients were ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9691b5d850be9a6bfb326f7ba142ea
https://pubmed.ncbi.nlm.nih.gov/8138682