Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Iwan Grin"'
Autor:
Stefanie M. Herbel, Lambert Moyon, Marvin Christ, Eslam M. Elsayed, Brian E. Caffrey, Silke Malmsheimer, Iwan Grin, Kerstin Hoffmann, Kristin Surmann, Sascha Blankenburg, Anna Lena Jung, Christina E. Herkt, Marco Borsò, Beyza Bozdag, Axel Imhof, Anke Becker, Samuel Wagner, Gert Bange, Uwe Völker, Wilhelm Bertrams, Annalisa Marsico, Bernd Schmeck
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 2042-2058 (2022)
Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and the tran
Externí odkaz:
https://doaj.org/article/3cfbe5db3b0f4145a005db5fed54388b
Autor:
Lea Krampen, Silke Malmsheimer, Iwan Grin, Thomas Trunk, Anja Lührmann, Jan-Willem de Gier, Samuel Wagner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Many bacteria export effector proteins even when two incompatible signal sequences are present, one which would lead to export and the other to inner membrane targeting. Here the authors show that such proteins feature decreased hydrophobicity or cog
Externí odkaz:
https://doaj.org/article/864e25c152e74479baf43777512bbf77
Autor:
Fabio Lino Gratani, Petra Horvatek, Tobias Geiger, Marina Borisova, Christoph Mayer, Iwan Grin, Samuel Wagner, Wieland Steinchen, Gert Bange, Ana Velic, Boris Maček, Christiane Wolz
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007514 (2018)
The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus aureus, (p)ppGpp is synthesized by the long RSH (RelA/SpoT homolog) enzyme, RelSau or by on
Externí odkaz:
https://doaj.org/article/ae16293203d94614b64136f0d696a328
Autor:
Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Matthias J Brunner, Patrizia Abrusci, Jun Yan, Mirita Franz-Wachtel, Charlotta Schärfe, Susann Zilkenat, Iwan Grin, Jorge E Galán, Oliver Kohlbacher, Susan Lea, Boris Macek, Thomas C Marlovits, Carol V Robinson, Samuel Wagner
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006071 (2016)
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into h
Externí odkaz:
https://doaj.org/article/47f61fc5df8947a58c7922337e021a69
Autor:
Melanie Nowak, Erwin Bohn, Iwan Grin, Sibel Westerhausen, Claudia E Torres-Vargas, Samuel Wagner, Ursula Bilitewski
Publikováno v:
Molecular microbiology
England
England
The elucidation of the molecular mechanisms of secretion through bacterial protein secretion systems is impeded by a lack of assays to quantitatively assess secretion kinetics. Also the analysis of the biological role of these secretion systems as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198a26fdaa8da76e9ede92defd405087
Autor:
Anja Lührmann, Thomas Trunk, Samuel Wagner, Silke Malmsheimer, Iwan Grin, Lea Krampen, Jan-Willem de Gier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Many bacteria export effector proteins fulfilling their function in membranes of a eukaryotic host. These effector membrane proteins appear to contain signals for two incompatible bacterial secretion pathways in the same protein: a specific export si
Autor:
Silke Malmsheimer, Iwan Grin, Claudia E Torres-Vargas, Samuel Wagner, Nidhi Singh, Sibel Westerhausen
Publikováno v:
FEMS microbiology letters. 365(19)
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells. They are able to secrete a great diversity of substrate proteins in order to modulate host cell function, and have e
Autor:
Monika Schütz, Iwan Grin, Marcus D. Hartmann, Alfonso Felipe-López, Andrei N. Lupas, Birte Hernandez Alvarez, Dirk Linke, Michael Hensel, Samuel Wagner, Johannes Madlung, Boris Macek, Guido Sauer
Publikováno v:
The Journal of Biological Chemistry
Background: Autotransporter adhesins reach the bacterial cell surface by a complex mechanism. Results: In the case of the autotransporter SadA from Salmonella, a lipoprotein assists in surface display. Conclusion: The similarity to eukaryotic MATH do
Publikováno v:
Biological chemistry. 398(2)
Gaining knowledge of the structural makeup of protein complexes is critical to advance our understanding of their formation and functions. This task is particularly challenging for transmembrane protein complexes, and grows ever more imposing with in
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences
Autotransport in Gram-negative bacteria denotes the ability of surface-localized proteins to cross the outer membrane (OM) autonomously. Autotransporters perform this task with the help of a β-barrel transmembrane domain localized in the OM. Differe