Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ivy Nj Hung"'
Autor:
Nathan P. Young, Gary G. Chiang, Andres Nevarez, Joan Chen, Tran Chinh Viet, Reich Siegfried Heinz, Theodore Michels, Eric Sung, Haleigh Howard, Christopher J. Wegerski, Ana Parra, Gregory S. Parker, Boreth Eam, Alan Xiang, Samuel Sperry, Jocelyn Staunton, Maria Barrera, Christian Nilewski, Kevin R. Webster, Garrick Packard, Sarah Fish, Jeff Clarine, Paul A. Sprengeler, Peggy A. Thompson, Ivy Nj Hung, Justin T. Ernst
Publikováno v:
Cancer Research. 78:DDT02-05
eFT226: A Selective and Highly Potent Inhibitor of Eukaryotic Initiation Factor 4A (eIF4A), a Novel Approach for the Treatment of Cancer Siegfried H Reich, Peggy A Thompson, Justin T Ernst, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Maria Bar
Autor:
Joan Chen, Jeff Clarine, Craig R. Stumpf, Paul A. Sprengeler, Christopher J. Wegerski, Michels Theodore, Garrick Kenneth Packard, Christian Nilewski, Jocelyn Staunton, Eric Sung, Kaveri Urklalan, Alan Xiang, Takasuke Mukaiyama, Reich Siegfried Heinz, Ivy Nj Hung, Justin T. Ernst, Kevin R. Webster, Gary G. Chiang, Gregory S. Parker, Andreas Nevarez, Peggy A. Thompson, Samuel Sperry, Maria Barrera, Ana Parra
Publikováno v:
Molecular Cancer Research. 18:B33-B33
Aberrant protein translation plays a role in the pathogenesis of multiple solid tumors and hematologic malignancies. The translation initiation factor eIF4E is essential for the translation of m7G-capped mRNA and is a key point of convergence for sev
Autor:
Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng
Publikováno v:
Journal of medicinal chemistry. 61(8)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosph
Autor:
Alan Xiang, Andreas Nevarez, Kaveri Urkalan, Peggy A. Thompson, Paul A. Sprengeler, Ana Parra, Christian Nilewski, Ivy Nj Hung, Justin T. Ernst, Joan Chen, Garrick Packard, Eric Sung, Gary G. Chiang, Gregory S. Parker, Reich Siegfried Heinz, Maria Barrera, Samuel Sperry, Craig R. Stumpf, Christopher J. Wegerski, Michels Theodore, Cody Parker, Jocelyn Staunton, Takasuke Mukaiyama, Vikas K. Goel, Kevin R. Webster, Jeff Clarine
Publikováno v:
Cancer Research. 79:1302-1302
The PI3K/mTOR pathway is commonly dysregulated in many hormone receptor-dependent tumors and plays a key role in promoting tumor growth and mediating drug resistance. In particular, PI3K and mTORC1/2 inhibitors have been intensively studied in the tr
Autor:
Tran Chinh Viet, Rajesh K. Sharma, Jolene Molter, Vikas K. Goel, Craig R. Stumpf, Christopher J. Wegerski, Paul A. Sprengeler, Gregory S. Parker, Kevin R. Webster, Ivy Nj Hung, Justin T. Ernst, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Reich Siegfried Heinz, Joan Chen, Vera Huang, Samuel Sperry
Publikováno v:
Cancer Research. 77:596-596
Dysregulated translation of messenger RNA (mRNA) plays a role in the pathogenesis of multiple solid tumors and hematological malignancies. MNK1 and MNK2 integrate signals from several oncogenic and immune signaling pathways (including RAS, Toll-like
Autor:
Vera Huang, Stephen E. Webber, Tran Chinh Viet, Samuel Sperry, Peggy A. Thompson, Jolene Molter, Jocelyn Staunton, Paul A. Sprengeler, Gregory S. Parker, Joan Chen, Ivy Nj Hung, Justin T. Ernst, Gary G. Chiang, Craig R. Stumpf, Reich Siegfried Heinz, Christopher J. Wegerski, Vikas K. Goel, Kevin R. Webster
Publikováno v:
Cancer Research. 77:PR11-PR11
Purpose: This study was designed to evaluate the potential of eFT508 to selectively regulate key immune signaling pathways and enhance anti-tumor immunity as a monotherapy or in combination with checkpoint blockade in immunocompetent syngeneic cancer
Autor:
Joan Chen, Christopher J. Wegerski, Katti A. Jessen, Gary G. Chiang, Gregory S. Parker, Stephen E. Webber, Kevin R. Webster, Reich Siegfried Heinz, Vikas K Goel, Melissa Neal, Ivy Nj Hung, Paul A. Sprengeler, Peggy A. Thompson, Samuel Sperry, Vera Huang, James R. Appleman, Jolene Molter, Jocelyn Staunton
Publikováno v:
Blood. 126:1554-1554
Dysregulated translation of messenger RNA (mRNA) plays a role in the pathogenesis of multiple solid tumors and hematological malignancies. MNK1 and MNK2 integrate signals from several oncogenic and immune signaling pathways, including RAS, p38, and T