Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ivy Aneas"'
Autor:
Xiao Liu, Ivy Aneas, Noboru Sakabe, Rebecca L. Anderson, Christine Billstrand, Cristina Paz, Harjot Kaur, Brian Furner, Seong Choi, Adriana Y. Prichina, Elizabeth Ann L. Enninga, Haidong Dong, Amy Murtha, Gregory E. Crawford, John A. Kessler, William Grobman, Marcelo A. Nobrega, Sarosh Rana, Carole Ober
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The mechanisms that underlie the timing of labor in humans are largely unknown. In most pregnancies, labor is initiated at term (≥ 37 weeks gestation), but in a signifiicant number of women spontaneous labor occurs preterm and is associate
Externí odkaz:
https://doaj.org/article/36866406c8f749de8cd6bb855b2d226e
Autor:
Charles Washington, Matthew Dapas, Arjun Biddanda, Kevin M. Magnaye, Ivy Aneas, Britney A. Helling, Brooke Szczesny, Meher Preethi Boorgula, Margaret A. Taub, Eimear Kenny, Rasika A. Mathias, Kathleen C. Barnes, CAAPA, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Jessica D. Gereige, Melanie Makhija, Rebecca S. Gruchalla, Michelle A. Gill, Andrew H. Liu, Deepa Rastogi, William Busse, Peter J. Gergen, Cynthia M. Visness, Diane R. Gold, Tina Hartert, Christine C. Johnson, Robert F. Lemanske, Fernando D. Martinez, Rachel L. Miller, Dennis Ownby, Christine M. Seroogy, Anne L. Wright, Edward M. Zoratti, Leonard B. Bacharier, Meyer Kattan, George T. O’Connor, Robert A. Wood, Marcelo A. Nobrega, Matthew C. Altman, Daniel J. Jackson, James E. Gern, Christopher G. McKennan, Carole Ober
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Methods We tested for association with haplotypes at the most replicated and si
Externí odkaz:
https://doaj.org/article/0d8b1bafd774497eb37ab1773c9c191e
Autor:
Ivy Aneas, Donna C. Decker, Chanie L. Howard, Débora R. Sobreira, Noboru J. Sakabe, Kelly M. Blaine, Michelle M. Stein, Cara L. Hrusch, Lindsey E. Montefiori, Juan Tena, Kevin M. Magnaye, Selene M. Clay, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Edward T. Naureckas, Douglas K. Hogarth, Steven R. White, Jose Luis Gomez-Skarmeta, Nathan Schoetler, Carole Ober, Anne I. Sperling, Marcelo A. Nóbrega
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Susceptibility to asthma and severity of symptoms are regulated by a number of different genomic regions. Here the authors characterise a 5kb regulatory region and demonstrate genetic and topological regulation of IL33 and association with disease in
Externí odkaz:
https://doaj.org/article/91de69f13ca849d4bde27470e200f0b0
Autor:
Amelia C. Joslin, Débora R. Sobreira, Grace T. Hansen, Noboru J. Sakabe, Ivy Aneas, Lindsey E. Montefiori, Kathryn M. Farris, Jing Gu, Donna M. Lehman, Carole Ober, Xin He, Marcelo A. Nóbrega
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci
Externí odkaz:
https://doaj.org/article/fb7e892c9745454a8d337ec16d1a90bb
Autor:
Tao Bai, Chian-Yu Peng, Ivy Aneas, Noboru Sakabe, Daniela F. Requena, Christine Billstrand, Marcelo Nobrega, Carole Ober, Mana Parast, John A. Kessler
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102507- (2021)
Human trophoblast stem cells (hTSC) can be isolated from first trimester placenta but not from term placenta. Here we demonstrate that villous cytotrophoblasts (vCTB) from term placenta can be reprogrammed into induced trophoblastic stem-like cells (
Externí odkaz:
https://doaj.org/article/5260b42c7e944760acd4bd6695f277f8
Autor:
Virginia Chu Cheung, Chian-Yu Peng, Mirna Marinić, Noboru J. Sakabe, Ivy Aneas, Vincent J. Lynch, Carole Ober, Marcelo A. Nobrega, John A. Kessler
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109138- (2021)
Summary: Various human diseases and pregnancy-related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as spontaneous decidualization, and no existing hum
Externí odkaz:
https://doaj.org/article/f12da9fe6d524cb6bd0633fc2545a92b
Autor:
Lindsey E Montefiori, Debora R Sobreira, Noboru J Sakabe, Ivy Aneas, Amelia C Joslin, Grace T Hansen, Grazyna Bozek, Ivan P Moskowitz, Elizabeth M McNally, Marcelo A Nóbrega
Publikováno v:
eLife, Vol 7 (2018)
Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs); however, most loci are located in gene-distal non-coding regions and their target genes are not known. Here, we generated high-resolution promoter capture Hi-C (P
Externí odkaz:
https://doaj.org/article/074cffa7559f4a5c8b6225ec57ffee68
Autor:
Grace T. Hansen, Débora R. Sobreira, Zachary T. Weber, Alexis G. Thornburg, Ivy Aneas, Li Zhang, Noboru J. Sakabe, Amelia C. Joslin, Gabriela A. Haddad, Sophie M. Strobel, Samantha Laber, Farhath Sultana, Faezeh Sahebdel, Kohinoor Khan, Yang I. Li, Melina Claussnitzer, Liang Ye, Ricardo A. Battaglino, Marcelo A. Nóbrega
Publikováno v:
Nature Genetics. 55:461-470
Autor:
Steven R. White, Juan J. Tena, James E. Gern, Débora R. Sobreira, Chanie L. Howard, Kevin M. Magnaye, Carole Ober, Kelly M. Blaine, José Luis Gómez-Skarmeta, Noboru J. Sakabe, Cara L. Hrusch, Anne I. Sperling, Michelle M. Stein, Marcelo A. Nobrega, Edward T. Naureckas, Donna C. Decker, Ivy Aneas, Nathan Schoetler, Lindsey E. Montefiori, Daniel J. Jackson, Douglas K. Hogarth, Matthew C. Altman, Selene M. Clay
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as an enhancer-blocking element in vivo and in vi
Autor:
Noboru J. Sakabe, Ivy Aneas, Xin He, Carole Ober, Lindsey E. Montefiori, Amelia C Joslin, Jing Gu, Donna M. Lehman, Débora R. Sobreira, Marcelo A. Nobrega, Grace T Hansen, Kathryn M. Farris
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Genome-wide association studies (GWAS) have identified many disease-associated variants, yet mechanisms underlying these associations remain unclear. To understand obesity-associated variants, we generate gene regulatory annotations in adipocytes and