Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ivy A.W. Ho"'
Autor:
Ivy A.W. Ho, Rachel L. Y. Ho
Publikováno v:
Cancers, Vol 13, Iss 3686, p 3686 (2021)
Cancers
Cancers
Simple Summary Glioblastoma is the most malignant tumor of the brain. Over the years, prognosis for patients with glioblastoma has remained dismal despite advances in medical sciences. Glioblastoma is a highly vascularized tumor; however, antiangioge
Autor:
Jacqueline Y. T. Yeo, Ivy A.W. Ho, Beng Ti Ang, Phoebe Um, Nurashikin Bte Abdul Halim, Rachel L. Y. Ho, Carol Tang, Wai Hoe Ng, David M. Virshup, Siti Farah Bte Fadhlullah
Publikováno v:
Oncogene
Glioblastoma (GBM) is the most aggressive tumor of the brain. NF1, a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM. Dysregulated NF1 expression promotes cell invasion, proliferation, and tumorigenesis. Loss of NF1 ex
Autor:
Ivy A.W. Ho, Berwini Endaya, Catherine Y. L. Kok, Siao T. Chong, Paula Y.P. Lam, Kazuhiko Arima, Jennifer P. Newman, Kam M. Hui, Michael R. Waters, Edita Aliwarga, Edward Pan, Webster K. Cavenee, Tomohisa Horibe, Amyn A. Habib, Tomasz Kordula, Shou P. Guan, Grace Y. Wang, Wai Hoe Ng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic
Autor:
Winston Shim, Ivy A.W. Ho
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2017 (2017)
BioMed Research International, Vol 2017 (2017)
Glioblastoma is the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition to intrinsic molecular and genetic changes is also influenced by the microenvironmental ni
Autor:
Paula Y.P. Lam, Chang M. Guo, Ivy A.W. Ho, Kam M. Hui, Yulyana Yulyana, Jennifer P. Newman, Kian Chuan Sia
Publikováno v:
The FASEB Journal. 28:4359-4368
Human bone marrow-derived mesenchymal stem cells (MSCs) have the unique ability to home toward injuries or tumor sites. We have previously shown that the tumor-tropic property is dependent on the intrinsic expression and activity of the matrix remode
Autor:
Edwin Sandanaraj, Ivy A.W. Ho, N. Abdul Halim, Carol Tang, Wai Hoe Ng, Rachel L. Y. Ho, David M. Virshup, Beng Ti Ang, S.F. Fadhlullah, J. Yeo
Publikováno v:
ESMO Open. 3:A98-A99
Introduction Neurofibromin (NF1), a tumour suppressor and RAS-GTPase activating protein, is one of the highly mutated genes in cancer. Dysregulated NF1 expression promotes tumorigenesis, impairs learning and memory and affects neural development. Los
Autor:
Yulyana Yulyana, Kam M. Hui, Paula Y.P. Lam, Wai Hoe Ng, Chang M. Guo, Ivy A.W. Ho, Berwini Endaya
Publikováno v:
Stem Cells and Development. 22:1870-1882
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities th
Autor:
Paula Y.P. Lam, Artak Tovmasyan, Chang Ming Guo, Kam M. Hui, Wai Hoe Ng, Ivy A.W. Ho, Ines Batinic-Haberle, Jennifer P. Newman, Kian Chuan Sia, Yulyana Yulyana
Publikováno v:
Stem cell reviews and reports. 12(1)
Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant brain tumor displays high metabolic activity which perturbs its redox environment and in turn
Autor:
Kian Chuan Sia, Wei Kin Chong, Ivy A.W. Ho, Yulyana Yulyana, Berwini Endaya, Paula Y.P. Lam, Hung Huynh
Publikováno v:
The Journal of Gene Medicine. 12:848-858
Background Herpes simplex virus type-1 (HSV-1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad host range of vector transduction and a minimal immune response as a result of the absence
Publikováno v:
Peptides. 31:644-650
Poor prognosis of high grade gliomas coupled with the difficulty of widespread delivery of therapeutic agents prompted the search into new molecular targets. Our aim is to isolate glioma-specific peptide sequences that can be used for targeted delive