Výsledky vyhledávání - "Ivy A, Rosales"

Akademický článek

Exploring immune response toward transplanted human kidney tissues assembled from organoid building blocks

Autor: Thiago J. Borges, Yoshikazu Ganchiku, Jeffrey O. Aceves, Ronald van Gaal, Sebastien G.M. Uzel, Ivy A. Rosales, Jonathan E. Rubins, Kenichi Kobayashi, Ken Hiratsuka, Murat Tekguc, Guilherme T. Ribas, Karina Lima, Rodrigo B. Gassen, Ryuji Morizane, Jennifer A. Lewis, Leonardo V. Riella

Publikováno v: iScience, Vol 27, Iss 10, Pp 110957- (2024)

Summary: The increasing scarcity of organs and the significant morbidity linked to dialysis require the development of engineered kidney tissues from human-induced pluripotent stem cells. Integrative approaches that synergize scalable kidney organoid

Externí odkaz: https://doaj.org/article/a643a4f97bf94f35ad5928910be26236

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Akademický článek

Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation

Autor: Marion Goutard, Pierre Tawa, Yanis Berkane, Alec R. Andrews, Casie A. Pendexter, Reinier J. de Vries, Victor Pozzo, Golda Romano, Hyshem H. Lancia, Irina Filz von Reiterdank, Nicolas Bertheuil, Ivy A. Rosales, Ira Doressa Anne L. How, Mark A. Randolph, Alexandre G. Lellouch, Curtis L. Cetrulo, Korkut Uygun

Publikováno v: Transplant International, Vol 37 (2024)

The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP) is growin

Externí odkaz: https://doaj.org/article/a62d3e5b3d914106bb7bafd0c309c4e6

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Akademický článek

A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)

The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated

Externí odkaz: https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3

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Akademický článek

Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)

Background Non-invasive biomarkers of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis) are urgently needed. Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen 4 (CTLA4),

Externí odkaz: https://doaj.org/article/b2896a0a2c844123a9938a6aff85c060

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Akademický článek

Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism

Autor: Alexandre G. Lellouch, Alec R. Andrews, Gaelle Saviane, Zhi Yang Ng, Ilse M. Schol, Marion Goutard, Amon-Ra Gama, Ivy A. Rosales, Robert B. Colvin, Laurent A. Lantieri, Mark A. Randolph, Gilles Benichou, Curtis L. Cetrulo

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundVascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity. Induction of immune tolerance of VCAs would permit

Externí odkaz: https://doaj.org/article/9edd525b71754b0d840e1d03aaddef28

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Akademický článek

Eculizumab as a New Treatment for Severe Acute Post-infectious Glomerulonephritis: Two Case Reports

Autor: Hassib Chehade, Gabriella Guzzo, Francois Cachat, Samuel Rotman, Daniel Teta, Giuseppe Pantaleo, Salima Sadallah, Amita Sharma, Ivy A. Rosales, Nina Tolkoff-Rubin, Manuel Pascual

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Acute post-infections glomerulonephritis (APIGN) is a frequent cause of glomerulonephritis and represents the most common cause of acute glomerulonephritis in children. It can evolve to severe acute renal failure and chronic kidney disease or even en

Externí odkaz: https://doaj.org/article/88f4d7ec87f44cde87e5766a17fb0ad3

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