Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ivory D. Hills"'
Autor:
Amy S. Espeseth, Ivory D. Hills, Shawn J. Stachel, Thomas G. Steele, Georgia B. McGaughey, Sharie J. Haugabook, Samuel L. Graham, Paul Zuck, Timothy Allison, Pablo De Leon, Ashley Nomland, Katherine Tugusheva, Dennis Colussi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:17-20
A small molecule inhibitor of beta-secretase with a unique binding mode has been developed. Crystallographic determination of the enzyme-inhibitor complex shows the catalytic aspartate residues in the active site are not engaged in inhibitor binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f34b06add72f13c29e702f2f0a1a68
https://doi.org/10.1016/j.bmcl.2008.11.027
https://doi.org/10.1016/j.bmcl.2008.11.027
Autor:
Ashley Nomland, Ivory D. Hills
Publikováno v:
Tetrahedron Letters. 49:5511-5514
2-Quinolinecarboxaldehyde participates in a standard Henry reaction when combined with a nitroalkane and catalytic amounts of base. However, water is not readily eliminated from the resulting β-nitro alcohol intermediate to form the expected nitroal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f87f92faa6199eba072d425cf70f090
https://doi.org/10.1016/j.tetlet.2008.07.044
https://doi.org/10.1016/j.tetlet.2008.07.044
Autor:
Evgueni E. Nesterov, Jesse Skoch, Ivory D. Hills, Timothy M. Swager, Brian J. Bacskai, Scott B. Raymond
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 35:93-98
Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer's disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd820cada7a8ccd06041ccc8cc77fbc5
https://doi.org/10.1007/s00259-007-0708-7
https://doi.org/10.1007/s00259-007-0708-7
Publikováno v:
Angewandte Chemie. 115:5927-5930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2deca7bc4ff34d8c68aa6785fd65116
https://doi.org/10.1002/ange.200352858
https://doi.org/10.1002/ange.200352858
Autor:
Ashley Nomland, Dennis Colussi, Tim J. Allison, Samuel L. Graham, M. Katharine Holloway, Pablo De Leon, Hemaka A. Rajapakse, Hong Zhu, Sharie J. Haugabook, Sanjeev Munshi, Shawn J. Stachel, Ivory D. Hills, Beth Pietrak, Dawn Toolan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4993-4995
During our ongoing efforts to develop a small molecule inhibitor targeting the β-amyloid cleaving enzyme (BACE-1), we discovered a class of compounds bearing an aminoimidazole motif. Initial optimization led to potent compounds that have high Pgp ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21d58ec67fa0c78f7af660cdc17a4c
https://doi.org/10.1016/j.bmcl.2009.07.071
https://doi.org/10.1016/j.bmcl.2009.07.071
Publikováno v:
Organometallics. 21:4323-4325
A general method for the synthesis of new families of transition-metal-free 1,2-azaborolides (3) has been developed, based on a readily available precursor (1). These azaborolides react with a variety of transition-metal electrophiles to produce an u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20fdb567ccba39cc1c8a517772b0c616
https://doi.org/10.1021/om020533b
https://doi.org/10.1021/om020533b
Autor:
Ashley Nomland, Ivory D. Hills
Publikováno v:
ChemInform. 40
2-Quinolinecarboxaldehyde participates in a standard Henry reaction when combined with a nitroalkane and catalytic amounts of base. However, water is not readily eliminated from the resulting β-nitro alcohol intermediate to form the expected nitroal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::868acd7cefe0a07c28986fcb41a4481f
https://doi.org/10.1002/chin.200901157
https://doi.org/10.1002/chin.200901157
Autor:
Ivory D, Hills, Joseph P, Vacca
Publikováno v:
Current opinion in drug discoverydevelopment. 10(4)
Over the last six years, numerous research groups in both academia and industry have synthesized inhibitors of beta-amyloid cleaving enzyme-1 (BACE-1) in the hope of developing a therapy to halt or even reverse the progression of Alzheimer's disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a37c1b033b04bad1bdf20d23f6ee835c
https://pubmed.ncbi.nlm.nih.gov/17659479
https://pubmed.ncbi.nlm.nih.gov/17659479
Publikováno v:
ChemInform. 37
The synthesis and resolution of a new planar-chiral Lewis acid complex is described. The compound is applied to asymmetric Mukaiyama aldol reactions, leading to the formation of the desired product with good stereoselectivity. The sense of stereosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d26901c11a5783dacc810872578f7d
https://doi.org/10.1002/chin.200612030
https://doi.org/10.1002/chin.200612030
Autor:
Gregory C. Fu, Ivory D. Hills
Publikováno v:
Journal of the American Chemical Society. 126(41)
This communication describes a series of studies directed at obtaining a better understanding of the Heck reaction. For the first time, the postulated palladium-hydride intermediate (L2PdHX) in the catalytic cycle of the Heck arylation has been ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685008464aad794f33f65bd962a1a818
https://pubmed.ncbi.nlm.nih.gov/15479044
https://pubmed.ncbi.nlm.nih.gov/15479044